Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells

Thickened atherosclerotic plaques are prone to be hypoxic because of poor perfusion. In this study, we tested (a) whether reactive oxygen species (ROS) and c-Src play roles in hypoxic induction of HIF-1alpha protein and PAI-1 gene expression in the rabbit aortic smooth muscle cell line C2/2 cells an...

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Veröffentlicht in:	Cardiovascular research 2005-09, Vol.67 (4), p.714-722
Hauptverfasser:	SATO, Hiroko, SATO, Mahito, KANAI, Hiroyoshi, UCHIYAMA, Tsuyoshi, ISO, Tatsuya, OHYAMA, Yoshio, SAKAMOTO, Hironosuke, TAMURA, Junichi, NAGAI, Ryozo, KURABAYASHI, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Animals Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blotting, Northern Cardiology. Vascular system Catalase - pharmacology Cell Hypoxia Cell Line Flavonoids - pharmacology Hydrogen Peroxide - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Imidazoles - pharmacology Immunoblotting Medical sciences Microscopy, Fluorescence Mitochondria - metabolism Muscle, Smooth, Vascular Myocytes, Smooth Muscle - metabolism Naphthalenes - pharmacology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphorylation Plasminogen Activator Inhibitor 1 - genetics Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins pp60(c-src) - metabolism Pyrazoles - pharmacology Pyridines - pharmacology Pyrimidines - pharmacology Rabbits RNA, Messenger - analysis Rotenone - pharmacology
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