Dose determination of haloperidol, risperidone and olanzapine using an in vivo dopamine D2-receptor occupancy method in the rat

The purpose of the present study was to determine antipsychotic doses that achieve 80% striatal dopamine D2-receptor occupancy for haloperidol, risperidone and olanzapine in rats. Wistar rats were treated with normal saline vehicle (controls), haloperidol (0.25 and 0.5 mg/kg/day), risperidone (3, 5...

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Veröffentlicht in:	European journal of pharmacology 2006-07, Vol.540 (1-3), p.87-90
Hauptverfasser:	NAIKER, Dineshree V, CARTS, Stanley V, CATTS, Vibeke S, BEDI, Kuldip S, BRYAN-LLUKA, Lesley J
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analysis of Variance Animals Antipsychotic Agents - administration & dosage Benzodiazepines - administration & dosage Binding, Competitive - drug effects Biological and medical sciences Cerebellum - drug effects Cerebellum - metabolism Corpus Striatum - drug effects Corpus Striatum - metabolism Dose-Response Relationship, Drug Haloperidol - administration & dosage Male Medical sciences Pharmacology. Drug treatments Raclopride - metabolism Radioligand Assay Rats Rats, Wistar Receptors, Dopamine D2 - metabolism Risperidone - administration & dosage Tritium
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