Behavioral and physiological effects of a single injection of rat interferon-α on male Sprague–Dawley rats: A long-term evaluation

Interferon-α (IFN-α) is a cytokine used as a first line of defense against diseases such as cancer and hepatitis C. However, reports indicate that its effectiveness as a treatment is countered by central nervous system (CNS) disruptions in patients. Our work explored the possibility that it may also...

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Veröffentlicht in:	Brain research 2006-06, Vol.1095 (1), p.96-106
Hauptverfasser:	Kentner, A.C., Miguelez, M., James, J.S., Bielajew, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Behavior, Animal - drug effects Biological and medical sciences Body Temperature - drug effects Body Weight - drug effects Cytokine Dose-Response Relationship, Drug Drinking - drug effects Fundamental and applied biological sciences. Psychology General aspects. Models. Methods IFN-α Immunologic Factors - administration & dosage Interferon-alpha - administration & dosage Lethargy Locomotion - drug effects Locomotor activity Male Motor Activity - drug effects Physiology Piloerection Rats Rats, Sprague-Dawley Sickness behavior Stereotyped Behavior - drug effects Temperature Time Factors Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
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