Genetic regulatory networks programming hematopoietic stem cells and erythroid lineage specification

Erythroid cell production results from passage through cellular hierarchies dependent on differential gene expression under the control of transcription factors responsive to changing niches. We have constructed Genetic Regulatory Networks (GRNs) describing this process, based predominantly on mouse...

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Veröffentlicht in:	Developmental biology 2006-06, Vol.294 (2), p.525-540
Hauptverfasser:	Swiers, Gemma, Patient, Roger, Loose, Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Cell Lineage Erythroid lineage Escherichia coli Gene Expression Regulation, Developmental Hematopoiesis Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - physiology Mice Models, Genetic Network motif Signal Transduction - physiology Stem cell Transcription Factors - metabolism Transcriptional regulatory network
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