Conjugated linoleic acid evokes de-lipidation through the regulation of genes controlling lipid metabolism in adipose and liver tissue
Summary Conjugated linoleic acid (CLA) is a unique lipid that elicits dramatic reductions in adiposity in several animal models when included at ≤ 1% of the diet. Despite a flurry of investigations, the precise mechanisms by which conjugated linoleic acid elicits its dramatic effects in adipose tiss...
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| Veröffentlicht in: | Obesity reviews 2005-08, Vol.6 (3), p.247-258 |
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| creator | House, R. L. Cassady, J. P. Eisen, E. J. McIntosh, M. K. Odle, J. |
| description | Summary
Conjugated linoleic acid (CLA) is a unique lipid that elicits dramatic reductions in adiposity in several animal models when included at ≤ 1% of the diet. Despite a flurry of investigations, the precise mechanisms by which conjugated linoleic acid elicits its dramatic effects in adipose tissue and liver are still largely unknown. In vivo and in vitro analyses of physiological modifications imparted by conjugated linoleic acid on protein and gene expression suggest that conjugated linoleic acid exerts its de‐lipidating effects by modulating energy expenditure, apoptosis, fatty acid oxidation, lipolysis, stromal vascular cell differentiation and lipogenesis. The purpose of this review shall be to examine the recent advances and insights into conjugated linoleic acid's effects on obesity and lipid metabolism, specifically focused on changes in gene expression and physiology of liver and adipose tissue. |
| doi_str_mv | 10.1111/j.1467-789X.2005.00198.x |
| format | Article |
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Conjugated linoleic acid (CLA) is a unique lipid that elicits dramatic reductions in adiposity in several animal models when included at ≤ 1% of the diet. Despite a flurry of investigations, the precise mechanisms by which conjugated linoleic acid elicits its dramatic effects in adipose tissue and liver are still largely unknown. In vivo and in vitro analyses of physiological modifications imparted by conjugated linoleic acid on protein and gene expression suggest that conjugated linoleic acid exerts its de‐lipidating effects by modulating energy expenditure, apoptosis, fatty acid oxidation, lipolysis, stromal vascular cell differentiation and lipogenesis. The purpose of this review shall be to examine the recent advances and insights into conjugated linoleic acid's effects on obesity and lipid metabolism, specifically focused on changes in gene expression and physiology of liver and adipose tissue.</description><subject>Adipocyte</subject><subject>adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>Cattle</subject><subject>CLA</subject><subject>de-lipidation</subject><subject>Energy Metabolism - drug effects</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Humans</subject><subject>Linoleic Acids, Conjugated - pharmacology</subject><subject>Lipid Metabolism</subject><subject>Liver - metabolism</subject><subject>liver tissue</subject><subject>Mice</subject><subject>obesity</subject><subject>Obesity - genetics</subject><subject>Obesity - metabolism</subject><subject>Organ Size - drug effects</subject><subject>Rats</subject><issn>1467-7881</issn><issn>1467-789X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS0EoqXwCsgrdgl2fmxHYkNH0FZUFKHys7M89k3qqRMPdlKmL9DnxmlGwxK8uUfX3zl3cRDClOQ0vbebnFaMZ1w0P_OCkDonhDYi3z1Bx4ePpwct6BF6EeMmQbwp6XN0RBmpalaRY_Sw8sNm6tQIBjs7eAdWY6WtwXDnbyFiA5mzW2vUaP2Ax5vgp-4mTcABuskta9_iDoZEaz-MwbuU1OFHG-5hVGvvbOyxHbAydusjYDXM5-4g4NHGOMFL9KxVLsKr_TxB3z5-uF6dZ5dXZxer95eZrgkVGZiGk1JRyjXUhRGKK9UmVdSCEWAtbcHUa0XrUmtTFBWjVRproxhoKAQtT9CbJXcb_K8J4ih7GzU4pwbwU5RMEJEu8X-CBaVNwWmVQLGAOvgYA7RyG2yvwr2kRM5lyY2ce5BzJ3IuSz6WJXfJ-np_Y1r3YP4a9-0k4N0C_LYO7v87WF6dfk0i2bPFbuMIu4NdhVvJeMlr-ePzmfzCzq8_idPvsin_APnXtcg</recordid><startdate>200508</startdate><enddate>200508</enddate><creator>House, R. L.</creator><creator>Cassady, J. P.</creator><creator>Eisen, E. J.</creator><creator>McIntosh, M. K.</creator><creator>Odle, J.</creator><general>Blackwell Science Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200508</creationdate><title>Conjugated linoleic acid evokes de-lipidation through the regulation of genes controlling lipid metabolism in adipose and liver tissue</title><author>House, R. L. ; Cassady, J. P. ; Eisen, E. J. ; McIntosh, M. K. ; Odle, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5018-ed9703a117ce52d8a7aafe5225860e6f1fed5ba153ccd224614d22bda6ece2813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adipocyte</topic><topic>adipose tissue</topic><topic>Adipose Tissue - metabolism</topic><topic>Animals</topic><topic>Cattle</topic><topic>CLA</topic><topic>de-lipidation</topic><topic>Energy Metabolism - drug effects</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Humans</topic><topic>Linoleic Acids, Conjugated - pharmacology</topic><topic>Lipid Metabolism</topic><topic>Liver - metabolism</topic><topic>liver tissue</topic><topic>Mice</topic><topic>obesity</topic><topic>Obesity - genetics</topic><topic>Obesity - metabolism</topic><topic>Organ Size - drug effects</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>House, R. L.</creatorcontrib><creatorcontrib>Cassady, J. P.</creatorcontrib><creatorcontrib>Eisen, E. J.</creatorcontrib><creatorcontrib>McIntosh, M. K.</creatorcontrib><creatorcontrib>Odle, J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>House, R. L.</au><au>Cassady, J. P.</au><au>Eisen, E. J.</au><au>McIntosh, M. K.</au><au>Odle, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conjugated linoleic acid evokes de-lipidation through the regulation of genes controlling lipid metabolism in adipose and liver tissue</atitle><jtitle>Obesity reviews</jtitle><addtitle>Obes Rev</addtitle><date>2005-08</date><risdate>2005</risdate><volume>6</volume><issue>3</issue><spage>247</spage><epage>258</epage><pages>247-258</pages><issn>1467-7881</issn><eissn>1467-789X</eissn><abstract>Summary
Conjugated linoleic acid (CLA) is a unique lipid that elicits dramatic reductions in adiposity in several animal models when included at ≤ 1% of the diet. Despite a flurry of investigations, the precise mechanisms by which conjugated linoleic acid elicits its dramatic effects in adipose tissue and liver are still largely unknown. In vivo and in vitro analyses of physiological modifications imparted by conjugated linoleic acid on protein and gene expression suggest that conjugated linoleic acid exerts its de‐lipidating effects by modulating energy expenditure, apoptosis, fatty acid oxidation, lipolysis, stromal vascular cell differentiation and lipogenesis. The purpose of this review shall be to examine the recent advances and insights into conjugated linoleic acid's effects on obesity and lipid metabolism, specifically focused on changes in gene expression and physiology of liver and adipose tissue.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16045640</pmid><doi>10.1111/j.1467-789X.2005.00198.x</doi><tpages>12</tpages></addata></record> |
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| ispartof | Obesity reviews, 2005-08, Vol.6 (3), p.247-258 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adipocyte adipose tissue Adipose Tissue - metabolism Animals Cattle CLA de-lipidation Energy Metabolism - drug effects Gene Expression Regulation - drug effects Humans Linoleic Acids, Conjugated - pharmacology Lipid Metabolism Liver - metabolism liver tissue Mice obesity Obesity - genetics Obesity - metabolism Organ Size - drug effects Rats |
| title | Conjugated linoleic acid evokes de-lipidation through the regulation of genes controlling lipid metabolism in adipose and liver tissue |
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