Neuropeptide S Stimulates the Hypothalamo-Pituitary-Adrenal Axis and Inhibits Food Intake
Neuropeptide S (NPS) is a recently discovered peptide shown to be involved in the modulation of arousal and fear responses. It has also been shown that lateral ventricle administration of NPS causes a significant decrease in food intake. Neuropeptides involved in the modulation of arousal have been...
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| Veröffentlicht in: | Endocrinology (Philadelphia) 2006-07, Vol.147 (7), p.3510-3518 |
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| creator | Smith, Kirsty L Patterson, Michael Dhillo, Waljit S Patel, Sejal R Semjonous, Nina M Gardiner, James V Ghatei, Mohammad A Bloom, Stephen R |
| description | Neuropeptide S (NPS) is a recently discovered peptide shown to be involved in the modulation of arousal and fear responses. It has also been shown that lateral ventricle administration of NPS causes a significant decrease in food intake. Neuropeptides involved in the modulation of arousal have been shown to be involved in the regulation of the hypothalamo-pituitary adrenal (HPA) axis and food intake. In this study, we have examined the effect of intracerebroventricular (ICV) administration of NPS on behavior, regulation of the HPA axis, and food intake. ICV NPS significantly increased plasma ACTH and corticosterone 10 and 40 min after injection, respectively. A single ICV injection of NPS caused a significant increase in rearing activity as well as ambulatory movement for up to 45 min after injection. We then studied the effect of paraventricular nucleus (PVN) administration of NPS on the regulation of the HPA axis, behavior, and food intake. There was a significant increase in plasma ACTH and corticosterone after a single NPS PVN injection. Incubation of hypothalamic explants with increasing concentrations of NPS caused a significant increase in CRH and arginine vasopressin release. In addition, PVN administration of NPS dose-dependently inhibited food intake in the first hour after injection, although no effect on food intake was seen after this time. PVN administration of NPS caused a significant increase in rearing activity. These data demonstrate a novel role for NPS in the stimulation of the HPA axis. |
| doi_str_mv | 10.1210/en.2005-1280 |
| format | Article |
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It has also been shown that lateral ventricle administration of NPS causes a significant decrease in food intake. Neuropeptides involved in the modulation of arousal have been shown to be involved in the regulation of the hypothalamo-pituitary adrenal (HPA) axis and food intake. In this study, we have examined the effect of intracerebroventricular (ICV) administration of NPS on behavior, regulation of the HPA axis, and food intake. ICV NPS significantly increased plasma ACTH and corticosterone 10 and 40 min after injection, respectively. A single ICV injection of NPS caused a significant increase in rearing activity as well as ambulatory movement for up to 45 min after injection. We then studied the effect of paraventricular nucleus (PVN) administration of NPS on the regulation of the HPA axis, behavior, and food intake. There was a significant increase in plasma ACTH and corticosterone after a single NPS PVN injection. Incubation of hypothalamic explants with increasing concentrations of NPS caused a significant increase in CRH and arginine vasopressin release. In addition, PVN administration of NPS dose-dependently inhibited food intake in the first hour after injection, although no effect on food intake was seen after this time. PVN administration of NPS caused a significant increase in rearing activity. These data demonstrate a novel role for NPS in the stimulation of the HPA axis.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.2005-1280</identifier><identifier>PMID: 16574794</identifier><identifier>CODEN: ENDOAO</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adrenocorticotropic hormone ; Animals ; Argipressin ; Arousal ; Behavior, Animal ; Biological and medical sciences ; Corticosterone ; Corticosterone - blood ; Corticosterone - metabolism ; Eating ; Explants ; Feeding Behavior ; Food ; Food intake ; Fundamental and applied biological sciences. Psychology ; Humans ; Hypothalamic-pituitary-adrenal axis ; Hypothalamus ; Hypothalamus - metabolism ; Injection ; Intracerebroventricular administration ; Male ; Modulation ; Neuromodulation ; Neuropeptides ; Neuropeptides - physiology ; Paraventricular Hypothalamic Nucleus - metabolism ; Paraventricular nucleus ; Pituitary ; Pituitary Gland - metabolism ; Pituitary-Adrenal System - metabolism ; Rats ; Rats, Wistar ; Time Factors ; Vasopressin ; Ventricles (cerebral) ; Vertebrates: endocrinology</subject><ispartof>Endocrinology (Philadelphia), 2006-07, Vol.147 (7), p.3510-3518</ispartof><rights>Copyright © 2006 by The Endocrine Society 2006</rights><rights>2006 INIST-CNRS</rights><rights>Copyright © 2006 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-ee0a33c368cec52a53aeda10be32ef68dc3a17e1ef777aafc2d51f307c18c9573</citedby><cites>FETCH-LOGICAL-c492t-ee0a33c368cec52a53aeda10be32ef68dc3a17e1ef777aafc2d51f307c18c9573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17863076$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16574794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Kirsty L</creatorcontrib><creatorcontrib>Patterson, Michael</creatorcontrib><creatorcontrib>Dhillo, Waljit S</creatorcontrib><creatorcontrib>Patel, Sejal R</creatorcontrib><creatorcontrib>Semjonous, Nina M</creatorcontrib><creatorcontrib>Gardiner, James V</creatorcontrib><creatorcontrib>Ghatei, Mohammad A</creatorcontrib><creatorcontrib>Bloom, Stephen R</creatorcontrib><title>Neuropeptide S Stimulates the Hypothalamo-Pituitary-Adrenal Axis and Inhibits Food Intake</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>Neuropeptide S (NPS) is a recently discovered peptide shown to be involved in the modulation of arousal and fear responses. It has also been shown that lateral ventricle administration of NPS causes a significant decrease in food intake. Neuropeptides involved in the modulation of arousal have been shown to be involved in the regulation of the hypothalamo-pituitary adrenal (HPA) axis and food intake. In this study, we have examined the effect of intracerebroventricular (ICV) administration of NPS on behavior, regulation of the HPA axis, and food intake. ICV NPS significantly increased plasma ACTH and corticosterone 10 and 40 min after injection, respectively. A single ICV injection of NPS caused a significant increase in rearing activity as well as ambulatory movement for up to 45 min after injection. We then studied the effect of paraventricular nucleus (PVN) administration of NPS on the regulation of the HPA axis, behavior, and food intake. There was a significant increase in plasma ACTH and corticosterone after a single NPS PVN injection. Incubation of hypothalamic explants with increasing concentrations of NPS caused a significant increase in CRH and arginine vasopressin release. In addition, PVN administration of NPS dose-dependently inhibited food intake in the first hour after injection, although no effect on food intake was seen after this time. PVN administration of NPS caused a significant increase in rearing activity. These data demonstrate a novel role for NPS in the stimulation of the HPA axis.</description><subject>Adrenocorticotropic hormone</subject><subject>Animals</subject><subject>Argipressin</subject><subject>Arousal</subject><subject>Behavior, Animal</subject><subject>Biological and medical sciences</subject><subject>Corticosterone</subject><subject>Corticosterone - blood</subject><subject>Corticosterone - metabolism</subject><subject>Eating</subject><subject>Explants</subject><subject>Feeding Behavior</subject><subject>Food</subject><subject>Food intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hypothalamic-pituitary-adrenal axis</subject><subject>Hypothalamus</subject><subject>Hypothalamus - metabolism</subject><subject>Injection</subject><subject>Intracerebroventricular administration</subject><subject>Male</subject><subject>Modulation</subject><subject>Neuromodulation</subject><subject>Neuropeptides</subject><subject>Neuropeptides - physiology</subject><subject>Paraventricular Hypothalamic Nucleus - metabolism</subject><subject>Paraventricular nucleus</subject><subject>Pituitary</subject><subject>Pituitary Gland - metabolism</subject><subject>Pituitary-Adrenal System - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Time Factors</subject><subject>Vasopressin</subject><subject>Ventricles (cerebral)</subject><subject>Vertebrates: endocrinology</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1r3DAQBmBRWppN2lvPxVDaXuJUX7bk4xKaDwhtIe2hJzErj1mltuVIMjT_PlrWsFASehIDDzOaeQl5x-gZ44x-wfGMU1qVjGv6gqxYI6tSMUVfkhWlTJSKc3VEjmO8y6WUUrwmR6yulFSNXJHf33AOfsIpuRaL2-I2uWHuIWEs0haLq4fJpy30MPjyh0uzSxAeynUbcIS-WP91sYCxLa7Hrdu4FIsL73dVgj_4hrzqoI_4dnlPyK-Lrz_Pr8qb75fX5-ub0sqGpxKRghBW1NqirThUArAFRjcoOHa1bq0AppBhp5QC6CxvK9YJqizTtqmUOCGf9n2n4O9njMkMLlrsexjRz9HUmmrJJf8vzJcTiskmww__wDs_h7xwNIIJWmmulM7qdK9s8DEG7MwU3JDPYxg1u2QMjmaXjNklk_n7pem8GbA94CWKDD4uAKKFvgswWhcPTuk6b11n93nv_Dw9N7JcRoq9xLH1NrgRp4AxHrZ58qOPMQay5Q</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>Smith, Kirsty L</creator><creator>Patterson, Michael</creator><creator>Dhillo, Waljit S</creator><creator>Patel, Sejal R</creator><creator>Semjonous, Nina M</creator><creator>Gardiner, James V</creator><creator>Ghatei, Mohammad A</creator><creator>Bloom, Stephen R</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20060701</creationdate><title>Neuropeptide S Stimulates the Hypothalamo-Pituitary-Adrenal Axis and Inhibits Food Intake</title><author>Smith, Kirsty L ; Patterson, Michael ; Dhillo, Waljit S ; Patel, Sejal R ; Semjonous, Nina M ; Gardiner, James V ; Ghatei, Mohammad A ; Bloom, Stephen R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-ee0a33c368cec52a53aeda10be32ef68dc3a17e1ef777aafc2d51f307c18c9573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adrenocorticotropic hormone</topic><topic>Animals</topic><topic>Argipressin</topic><topic>Arousal</topic><topic>Behavior, Animal</topic><topic>Biological and medical sciences</topic><topic>Corticosterone</topic><topic>Corticosterone - blood</topic><topic>Corticosterone - metabolism</topic><topic>Eating</topic><topic>Explants</topic><topic>Feeding Behavior</topic><topic>Food</topic><topic>Food intake</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hypothalamic-pituitary-adrenal axis</topic><topic>Hypothalamus</topic><topic>Hypothalamus - metabolism</topic><topic>Injection</topic><topic>Intracerebroventricular administration</topic><topic>Male</topic><topic>Modulation</topic><topic>Neuromodulation</topic><topic>Neuropeptides</topic><topic>Neuropeptides - physiology</topic><topic>Paraventricular Hypothalamic Nucleus - metabolism</topic><topic>Paraventricular nucleus</topic><topic>Pituitary</topic><topic>Pituitary Gland - metabolism</topic><topic>Pituitary-Adrenal System - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Time Factors</topic><topic>Vasopressin</topic><topic>Ventricles (cerebral)</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Kirsty L</creatorcontrib><creatorcontrib>Patterson, Michael</creatorcontrib><creatorcontrib>Dhillo, Waljit S</creatorcontrib><creatorcontrib>Patel, Sejal R</creatorcontrib><creatorcontrib>Semjonous, Nina M</creatorcontrib><creatorcontrib>Gardiner, James V</creatorcontrib><creatorcontrib>Ghatei, Mohammad A</creatorcontrib><creatorcontrib>Bloom, Stephen R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Kirsty L</au><au>Patterson, Michael</au><au>Dhillo, Waljit S</au><au>Patel, Sejal R</au><au>Semjonous, Nina M</au><au>Gardiner, James V</au><au>Ghatei, Mohammad A</au><au>Bloom, Stephen R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropeptide S Stimulates the Hypothalamo-Pituitary-Adrenal Axis and Inhibits Food Intake</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>147</volume><issue>7</issue><spage>3510</spage><epage>3518</epage><pages>3510-3518</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><coden>ENDOAO</coden><abstract>Neuropeptide S (NPS) is a recently discovered peptide shown to be involved in the modulation of arousal and fear responses. It has also been shown that lateral ventricle administration of NPS causes a significant decrease in food intake. Neuropeptides involved in the modulation of arousal have been shown to be involved in the regulation of the hypothalamo-pituitary adrenal (HPA) axis and food intake. In this study, we have examined the effect of intracerebroventricular (ICV) administration of NPS on behavior, regulation of the HPA axis, and food intake. ICV NPS significantly increased plasma ACTH and corticosterone 10 and 40 min after injection, respectively. A single ICV injection of NPS caused a significant increase in rearing activity as well as ambulatory movement for up to 45 min after injection. We then studied the effect of paraventricular nucleus (PVN) administration of NPS on the regulation of the HPA axis, behavior, and food intake. There was a significant increase in plasma ACTH and corticosterone after a single NPS PVN injection. Incubation of hypothalamic explants with increasing concentrations of NPS caused a significant increase in CRH and arginine vasopressin release. In addition, PVN administration of NPS dose-dependently inhibited food intake in the first hour after injection, although no effect on food intake was seen after this time. PVN administration of NPS caused a significant increase in rearing activity. These data demonstrate a novel role for NPS in the stimulation of the HPA axis.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>16574794</pmid><doi>10.1210/en.2005-1280</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adrenocorticotropic hormone Animals Argipressin Arousal Behavior, Animal Biological and medical sciences Corticosterone Corticosterone - blood Corticosterone - metabolism Eating Explants Feeding Behavior Food Food intake Fundamental and applied biological sciences. Psychology Humans Hypothalamic-pituitary-adrenal axis Hypothalamus Hypothalamus - metabolism Injection Intracerebroventricular administration Male Modulation Neuromodulation Neuropeptides Neuropeptides - physiology Paraventricular Hypothalamic Nucleus - metabolism Paraventricular nucleus Pituitary Pituitary Gland - metabolism Pituitary-Adrenal System - metabolism Rats Rats, Wistar Time Factors Vasopressin Ventricles (cerebral) Vertebrates: endocrinology |
| title | Neuropeptide S Stimulates the Hypothalamo-Pituitary-Adrenal Axis and Inhibits Food Intake |
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