Association between alcohol consumption and subclinical carotid atherosclerosis : The study of health in Pomerania
Epidemiologic studies have shown a J-shaped association between alcohol consumption and vascular diseases. However, only few studies have reported on the association between alcohol intake and subclinical atherosclerosis. The aim of the study was to investigate the relation between alcohol intake an...
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| Veröffentlicht in: | Stroke (1970) 2005-08, Vol.36 (8), p.1746-1752 |
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| container_title | Stroke (1970) |
| container_volume | 36 |
| creator | SCHMINKE, Ulf LUEDEMANN, Jan BERGER, Klaus ALTE, Dietrich MITUSCH, Rolf WOOD, William G JASCHINSKI, Anke BARNOW, Sven JOHN, Ulrich KESSLER, Christof |
| description | Epidemiologic studies have shown a J-shaped association between alcohol consumption and vascular diseases. However, only few studies have reported on the association between alcohol intake and subclinical atherosclerosis. The aim of the study was to investigate the relation between alcohol intake and carotid intima-media thickness (IMT) in participants of the population-based Study of Health in Pomerania.
In 1230 men and 1190 women, the mean IMT of the right and left common carotid arteries was measured by B-mode ultrasonography. Alcohol consumption was assessed with a computer-assisted face-to-face interview.
In men, carotid IMT as a function of alcohol intake was depicted as a J-shaped curve with a nadir for the alcohol intake category of 61 to 80 g/d. Linear regression models controlled for age, diabetes, systolic blood pressure, leisure time physical activity, food frequency patterns, smoking status, and education revealed a significant inverse association between IMT and alcohol intake < or =80 g/d in men (beta=-0.009, P |
| doi_str_mv | 10.1161/01.STR.0000173159.65228.68 |
| format | Article |
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In 1230 men and 1190 women, the mean IMT of the right and left common carotid arteries was measured by B-mode ultrasonography. Alcohol consumption was assessed with a computer-assisted face-to-face interview.
In men, carotid IMT as a function of alcohol intake was depicted as a J-shaped curve with a nadir for the alcohol intake category of 61 to 80 g/d. Linear regression models controlled for age, diabetes, systolic blood pressure, leisure time physical activity, food frequency patterns, smoking status, and education revealed a significant inverse association between IMT and alcohol intake < or =80 g/d in men (beta=-0.009, P<0.02), which became insignificant after further controlling for HDL cholesterol and fibrinogen (beta=-0.007, P=NS). In women, neither a J-shaped relation nor significant differences in IMT between the drinking and nondrinking groups were found.
Alcohol consumption is inversely correlated with carotid IMT in men but not in women. However, the total daily level of alcohol intake that shows a maximum protective effect against atherosclerosis is above the threshold where severe alcohol related comorbidity and organ damage have been reported.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.0000173159.65228.68</identifier><identifier>PMID: 16002763</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Alcohol Drinking ; Animals ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Cardiology. Vascular system ; Carotid Arteries - pathology ; Carotid Artery Diseases - epidemiology ; Carotid Artery Diseases - etiology ; Carotid Artery Diseases - pathology ; Cholesterol, HDL - metabolism ; Female ; Germany ; Humans ; Linear Models ; Male ; Medical sciences ; Middle Aged ; Models, Statistical ; Multivariate Analysis ; Neurology ; Neurosurgery ; Regression Analysis ; Sex Factors ; Skull, brain, vascular surgery ; Smoking ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tunica Intima - diagnostic imaging ; Tunica Intima - pathology ; Tunica Media - diagnostic imaging ; Tunica Media - pathology ; Ultrasonography ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2005-08, Vol.36 (8), p.1746-1752</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-4f24f984840d7eacc3945f4e28a5f5e17ada53a6108c4d2748777ff5e2417ce63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3673,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17008426$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16002763$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHMINKE, Ulf</creatorcontrib><creatorcontrib>LUEDEMANN, Jan</creatorcontrib><creatorcontrib>BERGER, Klaus</creatorcontrib><creatorcontrib>ALTE, Dietrich</creatorcontrib><creatorcontrib>MITUSCH, Rolf</creatorcontrib><creatorcontrib>WOOD, William G</creatorcontrib><creatorcontrib>JASCHINSKI, Anke</creatorcontrib><creatorcontrib>BARNOW, Sven</creatorcontrib><creatorcontrib>JOHN, Ulrich</creatorcontrib><creatorcontrib>KESSLER, Christof</creatorcontrib><title>Association between alcohol consumption and subclinical carotid atherosclerosis : The study of health in Pomerania</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Epidemiologic studies have shown a J-shaped association between alcohol consumption and vascular diseases. However, only few studies have reported on the association between alcohol intake and subclinical atherosclerosis. The aim of the study was to investigate the relation between alcohol intake and carotid intima-media thickness (IMT) in participants of the population-based Study of Health in Pomerania.
In 1230 men and 1190 women, the mean IMT of the right and left common carotid arteries was measured by B-mode ultrasonography. Alcohol consumption was assessed with a computer-assisted face-to-face interview.
In men, carotid IMT as a function of alcohol intake was depicted as a J-shaped curve with a nadir for the alcohol intake category of 61 to 80 g/d. Linear regression models controlled for age, diabetes, systolic blood pressure, leisure time physical activity, food frequency patterns, smoking status, and education revealed a significant inverse association between IMT and alcohol intake < or =80 g/d in men (beta=-0.009, P<0.02), which became insignificant after further controlling for HDL cholesterol and fibrinogen (beta=-0.007, P=NS). In women, neither a J-shaped relation nor significant differences in IMT between the drinking and nondrinking groups were found.
Alcohol consumption is inversely correlated with carotid IMT in men but not in women. However, the total daily level of alcohol intake that shows a maximum protective effect against atherosclerosis is above the threshold where severe alcohol related comorbidity and organ damage have been reported.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcohol Drinking</subject><subject>Animals</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Arteries - pathology</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Carotid Artery Diseases - etiology</subject><subject>Carotid Artery Diseases - pathology</subject><subject>Cholesterol, HDL - metabolism</subject><subject>Female</subject><subject>Germany</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Models, Statistical</subject><subject>Multivariate Analysis</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Regression Analysis</subject><subject>Sex Factors</subject><subject>Skull, brain, vascular surgery</subject><subject>Smoking</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tunica Intima - diagnostic imaging</subject><subject>Tunica Intima - pathology</subject><subject>Tunica Media - diagnostic imaging</subject><subject>Tunica Media - pathology</subject><subject>Ultrasonography</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkN1q3DAQRkVJaTZpX6GIQnpnR3-W5NyFkCaBQEq7vRaz8gir2NbWsgl5-yrJwupiJPjOjJhDyDfOas41v2S8_r39VbNyuJG8aWvdCGFrbT-QDW-EqpQW9oRsGJNtJVTbnpKznP8WXkjbfCKnXJen0XJD5uuck4-wxDTRHS7PiBOFwac-DdSnKa_j_i2DqaN53fkhTtFDyWBOS-woLD3OKfvhtcZMr-i2R5qXtXuhKdAeYVh6Gif6M404wxThM_kYYMj45XCfkz8_brc399Xj093DzfVj5aXQS6WCUKG1yirWGQTvZauaoFBYaEKD3EAHjQTNmfWqE0ZZY0woiVDceNTynHx_n7uf078V8-LGmD0OA0yY1uy0ZVYazgp49Q76skKeMbj9HEeYXxxn7tW4Y9wV4-5o3L0ZLyNK89fDL-tuxO7YelBcgIsDALmIC8WBj_nIGcasElr-B6WNi6o</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>SCHMINKE, Ulf</creator><creator>LUEDEMANN, Jan</creator><creator>BERGER, Klaus</creator><creator>ALTE, Dietrich</creator><creator>MITUSCH, Rolf</creator><creator>WOOD, William G</creator><creator>JASCHINSKI, Anke</creator><creator>BARNOW, Sven</creator><creator>JOHN, Ulrich</creator><creator>KESSLER, Christof</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Association between alcohol consumption and subclinical carotid atherosclerosis : The study of health in Pomerania</title><author>SCHMINKE, Ulf ; LUEDEMANN, Jan ; BERGER, Klaus ; ALTE, Dietrich ; MITUSCH, Rolf ; WOOD, William G ; JASCHINSKI, Anke ; BARNOW, Sven ; JOHN, Ulrich ; KESSLER, Christof</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-4f24f984840d7eacc3945f4e28a5f5e17ada53a6108c4d2748777ff5e2417ce63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcohol Drinking</topic><topic>Animals</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Arteries - pathology</topic><topic>Carotid Artery Diseases - epidemiology</topic><topic>Carotid Artery Diseases - etiology</topic><topic>Carotid Artery Diseases - pathology</topic><topic>Cholesterol, HDL - metabolism</topic><topic>Female</topic><topic>Germany</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Models, Statistical</topic><topic>Multivariate Analysis</topic><topic>Neurology</topic><topic>Neurosurgery</topic><topic>Regression Analysis</topic><topic>Sex Factors</topic><topic>Skull, brain, vascular surgery</topic><topic>Smoking</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tunica Intima - diagnostic imaging</topic><topic>Tunica Intima - pathology</topic><topic>Tunica Media - diagnostic imaging</topic><topic>Tunica Media - pathology</topic><topic>Ultrasonography</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHMINKE, Ulf</creatorcontrib><creatorcontrib>LUEDEMANN, Jan</creatorcontrib><creatorcontrib>BERGER, Klaus</creatorcontrib><creatorcontrib>ALTE, Dietrich</creatorcontrib><creatorcontrib>MITUSCH, Rolf</creatorcontrib><creatorcontrib>WOOD, William G</creatorcontrib><creatorcontrib>JASCHINSKI, Anke</creatorcontrib><creatorcontrib>BARNOW, Sven</creatorcontrib><creatorcontrib>JOHN, Ulrich</creatorcontrib><creatorcontrib>KESSLER, Christof</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHMINKE, Ulf</au><au>LUEDEMANN, Jan</au><au>BERGER, Klaus</au><au>ALTE, Dietrich</au><au>MITUSCH, Rolf</au><au>WOOD, William G</au><au>JASCHINSKI, Anke</au><au>BARNOW, Sven</au><au>JOHN, Ulrich</au><au>KESSLER, Christof</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between alcohol consumption and subclinical carotid atherosclerosis : The study of health in Pomerania</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>36</volume><issue>8</issue><spage>1746</spage><epage>1752</epage><pages>1746-1752</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Epidemiologic studies have shown a J-shaped association between alcohol consumption and vascular diseases. However, only few studies have reported on the association between alcohol intake and subclinical atherosclerosis. The aim of the study was to investigate the relation between alcohol intake and carotid intima-media thickness (IMT) in participants of the population-based Study of Health in Pomerania.
In 1230 men and 1190 women, the mean IMT of the right and left common carotid arteries was measured by B-mode ultrasonography. Alcohol consumption was assessed with a computer-assisted face-to-face interview.
In men, carotid IMT as a function of alcohol intake was depicted as a J-shaped curve with a nadir for the alcohol intake category of 61 to 80 g/d. Linear regression models controlled for age, diabetes, systolic blood pressure, leisure time physical activity, food frequency patterns, smoking status, and education revealed a significant inverse association between IMT and alcohol intake < or =80 g/d in men (beta=-0.009, P<0.02), which became insignificant after further controlling for HDL cholesterol and fibrinogen (beta=-0.007, P=NS). In women, neither a J-shaped relation nor significant differences in IMT between the drinking and nondrinking groups were found.
Alcohol consumption is inversely correlated with carotid IMT in men but not in women. However, the total daily level of alcohol intake that shows a maximum protective effect against atherosclerosis is above the threshold where severe alcohol related comorbidity and organ damage have been reported.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16002763</pmid><doi>10.1161/01.STR.0000173159.65228.68</doi><tpages>7</tpages></addata></record> |
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| ispartof | Stroke (1970), 2005-08, Vol.36 (8), p.1746-1752 |
| issn | 0039-2499 1524-4628 |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Adult Aged Alcohol Drinking Animals Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Pressure Cardiology. Vascular system Carotid Arteries - pathology Carotid Artery Diseases - epidemiology Carotid Artery Diseases - etiology Carotid Artery Diseases - pathology Cholesterol, HDL - metabolism Female Germany Humans Linear Models Male Medical sciences Middle Aged Models, Statistical Multivariate Analysis Neurology Neurosurgery Regression Analysis Sex Factors Skull, brain, vascular surgery Smoking Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tunica Intima - diagnostic imaging Tunica Intima - pathology Tunica Media - diagnostic imaging Tunica Media - pathology Ultrasonography Vascular diseases and vascular malformations of the nervous system |
| title | Association between alcohol consumption and subclinical carotid atherosclerosis : The study of health in Pomerania |
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