The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast Cancer Cells

Estrogen plays a crucial role in the development of breast cancer, and the inhibition of estrogen synthesis has been an important target for the prevention and treatment of this disease. The rate-limiting reaction of the hormone biosynthesis is catalyzed by cytochrome P450 (CYP) 19 enzyme or aromata...

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Veröffentlicht in:	Toxicological sciences 2006-07, Vol.92 (1), p.71-77
Hauptverfasser:	Wang, Yun, Lee, Kai Woo, Chan, Franky L., Chen, Shiuan, Leung, Lai K.
Format:	Artikel
Sprache:	eng
Schlagworte:	aromatase Aromatase - genetics Aromatase - metabolism Aromatase Inhibitors - pharmacology Base Sequence breast cancer cell proliferation Breast Neoplasms - enzymology Cell Line, Tumor Cell Proliferation - drug effects DNA Primers Humans Kinetics Promoter Regions, Genetic resveratrol RNA, Messenger - genetics Stilbenes - pharmacology Testosterone - pharmacology Vitaceae Wine - analysis
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