Activation of p75NTR by proBDNF facilitates hippocampal long-term depression

Pro- and mature brain-derived neurotrophic factor (BDNF) activate two distinct receptors: p75 neurotrophin receptor (p75 NTR ) and TrkB. Mature BDNF facilitates hippocampal synaptic potentiation through TrkB. Here we report that proBDNF, by activating p75 NTR , facilitates hippocampal long-term depr...

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Veröffentlicht in:	Nature neuroscience 2005-08, Vol.8 (8), p.1069-1077
Hauptverfasser:	Woo, Newton H, Teng, Henry K, Siao, Chia-Jen, Chiaruttini, Cristina, Pang, Petti T, Milner, Teresa A, Hempstead, Barbara L, Lu, Bai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain-Derived Neurotrophic Factor - pharmacology Cells, Cultured Dendrites - metabolism Dendrites - ultrastructure Growth factor receptors Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiology Hippocampus - ultrastructure In Vitro Techniques Long-Term Synaptic Depression - physiology Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Electron Nerve Endings - metabolism Nerve Endings - ultrastructure Neurobiology Neuroplasticity Neurosciences Neurotrophic functions Physiological aspects Protein Precursors - pharmacology Receptor, Nerve Growth Factor Receptors, N-Methyl-D-Aspartate - metabolism Receptors, Nerve Growth Factor - deficiency Receptors, Nerve Growth Factor - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology
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