Tubular transporters and clearance of adefovir

Adefovir is transported by the organic anion transporter (OAT1) and the multidrug resistant protein (MRP2, 4 and 5). We studied adefovir clearance in rat after inhibition of transporters by probenecid and in mutant transport-deficient (TR−) rats, in which MRP2 is lacking. After treatment by probenec...

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Veröffentlicht in:	European journal of pharmacology 2006-07, Vol.540 (1), p.168-174
Hauptverfasser:	Servais, Aude, Lechat, Philippe, Zahr, Noël, Urien, Saik, Aymard, Guy, Chantal Jaudon, Marie, Deray, Gilbert, Isnard Bagnis, Corinne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adefovir clearance Adenine - analogs & derivatives Adenine - blood Adenine - pharmacokinetics Adenine - urine Animals ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - physiology Biological and medical sciences Biological Transport - drug effects Biological Transport - physiology Chromatography, High Pressure Liquid Coproporphyrins - urine Immunosuppressive Agents - blood Immunosuppressive Agents - pharmacokinetics Immunosuppressive Agents - urine Kidney Tubules - drug effects Kidney Tubules - metabolism Male Medical sciences Metabolic Clearance Rate - drug effects Models, Biological Mutation - genetics Organic Anion Transport Protein 1 - antagonists & inhibitors Organic Anion Transport Protein 1 - physiology Organic anion transporter Organophosphonates - blood Organophosphonates - pharmacokinetics Organophosphonates - urine Pharmacology. Drug treatments Probenecid Probenecid - blood Probenecid - pharmacology Rats Rats, Wistar Time Factors TR− rat Uricosuric Agents - pharmacology
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