Procalcitonin as a predictor of severe appendicitis in children
The aim of this study was to assess the diagnostic value of procalcitonin (PCT) in 212 children with appendicitis and compare it with that of the standard diagnostic modalities, C-reactive protein (CRP) level, leukocyte count, and abdominal ultrasound findings, in relation to the surgical and histol...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2005-07, Vol.24 (7), p.484-487 |
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| container_title | European journal of clinical microbiology & infectious diseases |
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| creator | KAFETZIS, D. A VELISSARIOU, I. M NIKOLAIDES, P SKLAVOS, M MAKTABI, M SPYRIDIS, G KAFETZIS, D. D ANDROULAKAKIS, E |
| description | The aim of this study was to assess the diagnostic value of procalcitonin (PCT) in 212 children with appendicitis and compare it with that of the standard diagnostic modalities, C-reactive protein (CRP) level, leukocyte count, and abdominal ultrasound findings, in relation to the surgical and histological findings of the appendix. A PCT value of >0.5 ng/ml was found to be indicative of perforation or gangrene with 73.4% sensitivity and 94.6% specificity, a CRP level of >50 mg/l and a leukocyte count of >10(4)/mm3 were useful diagnostic markers for perforation, while abdominal ultrasonography had a sensitivity of 82.8% and a specificity of 91.2% for detecting appendicitis with imaging findings. PCT measurement seems to be a useful adjunctive tool for diagnosing acute necrotizing appendicitis or perforation, and surgical exploration will probably be required in patients with PCT values >0.5 ng/ml. |
| doi_str_mv | 10.1007/s10096-005-1360-4 |
| format | Article |
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A ; VELISSARIOU, I. M ; NIKOLAIDES, P ; SKLAVOS, M ; MAKTABI, M ; SPYRIDIS, G ; KAFETZIS, D. D ; ANDROULAKAKIS, E</creator><creatorcontrib>KAFETZIS, D. A ; VELISSARIOU, I. M ; NIKOLAIDES, P ; SKLAVOS, M ; MAKTABI, M ; SPYRIDIS, G ; KAFETZIS, D. D ; ANDROULAKAKIS, E</creatorcontrib><description>The aim of this study was to assess the diagnostic value of procalcitonin (PCT) in 212 children with appendicitis and compare it with that of the standard diagnostic modalities, C-reactive protein (CRP) level, leukocyte count, and abdominal ultrasound findings, in relation to the surgical and histological findings of the appendix. A PCT value of >0.5 ng/ml was found to be indicative of perforation or gangrene with 73.4% sensitivity and 94.6% specificity, a CRP level of >50 mg/l and a leukocyte count of >10(4)/mm3 were useful diagnostic markers for perforation, while abdominal ultrasonography had a sensitivity of 82.8% and a specificity of 91.2% for detecting appendicitis with imaging findings. PCT measurement seems to be a useful adjunctive tool for diagnosing acute necrotizing appendicitis or perforation, and surgical exploration will probably be required in patients with PCT values >0.5 ng/ml.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-005-1360-4</identifier><identifier>PMID: 15995845</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Appendicitis ; Appendicitis - blood ; Appendicitis - diagnosis ; Biological and medical sciences ; Biomarkers - blood ; C-Reactive Protein ; Calcitonin - blood ; Calcitonin Gene-Related Peptide ; Child ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Infectious diseases ; Leukocyte Count ; Male ; Medical diagnosis ; Medical sciences ; Other diseases. Semiology ; Protein Precursors - blood ; Sensitivity and Specificity ; Stomach. Duodenum. Small intestine. Colon. Rectum. 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A</creatorcontrib><creatorcontrib>VELISSARIOU, I. M</creatorcontrib><creatorcontrib>NIKOLAIDES, P</creatorcontrib><creatorcontrib>SKLAVOS, M</creatorcontrib><creatorcontrib>MAKTABI, M</creatorcontrib><creatorcontrib>SPYRIDIS, G</creatorcontrib><creatorcontrib>KAFETZIS, D. D</creatorcontrib><creatorcontrib>ANDROULAKAKIS, E</creatorcontrib><title>Procalcitonin as a predictor of severe appendicitis in children</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>The aim of this study was to assess the diagnostic value of procalcitonin (PCT) in 212 children with appendicitis and compare it with that of the standard diagnostic modalities, C-reactive protein (CRP) level, leukocyte count, and abdominal ultrasound findings, in relation to the surgical and histological findings of the appendix. A PCT value of >0.5 ng/ml was found to be indicative of perforation or gangrene with 73.4% sensitivity and 94.6% specificity, a CRP level of >50 mg/l and a leukocyte count of >10(4)/mm3 were useful diagnostic markers for perforation, while abdominal ultrasonography had a sensitivity of 82.8% and a specificity of 91.2% for detecting appendicitis with imaging findings. PCT measurement seems to be a useful adjunctive tool for diagnosing acute necrotizing appendicitis or perforation, and surgical exploration will probably be required in patients with PCT values >0.5 ng/ml.</description><subject>Appendicitis</subject><subject>Appendicitis - blood</subject><subject>Appendicitis - diagnosis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein</subject><subject>Calcitonin - blood</subject><subject>Calcitonin Gene-Related Peptide</subject><subject>Child</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Protein Precursors - blood</subject><subject>Sensitivity and Specificity</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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A ; VELISSARIOU, I. M ; NIKOLAIDES, P ; SKLAVOS, M ; MAKTABI, M ; SPYRIDIS, G ; KAFETZIS, D. D ; ANDROULAKAKIS, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-5e00f4455a0422758c6f2b1947c7068a9e97b69c5fb3333eaec5e255d5d6fe83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Appendicitis</topic><topic>Appendicitis - blood</topic><topic>Appendicitis - diagnosis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein</topic><topic>Calcitonin - blood</topic><topic>Calcitonin Gene-Related Peptide</topic><topic>Child</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Other diseases. 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A</au><au>VELISSARIOU, I. M</au><au>NIKOLAIDES, P</au><au>SKLAVOS, M</au><au>MAKTABI, M</au><au>SPYRIDIS, G</au><au>KAFETZIS, D. D</au><au>ANDROULAKAKIS, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Procalcitonin as a predictor of severe appendicitis in children</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>24</volume><issue>7</issue><spage>484</spage><epage>487</epage><pages>484-487</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>The aim of this study was to assess the diagnostic value of procalcitonin (PCT) in 212 children with appendicitis and compare it with that of the standard diagnostic modalities, C-reactive protein (CRP) level, leukocyte count, and abdominal ultrasound findings, in relation to the surgical and histological findings of the appendix. A PCT value of >0.5 ng/ml was found to be indicative of perforation or gangrene with 73.4% sensitivity and 94.6% specificity, a CRP level of >50 mg/l and a leukocyte count of >10(4)/mm3 were useful diagnostic markers for perforation, while abdominal ultrasonography had a sensitivity of 82.8% and a specificity of 91.2% for detecting appendicitis with imaging findings. PCT measurement seems to be a useful adjunctive tool for diagnosing acute necrotizing appendicitis or perforation, and surgical exploration will probably be required in patients with PCT values >0.5 ng/ml.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>15995845</pmid><doi>10.1007/s10096-005-1360-4</doi><tpages>4</tpages></addata></record> |
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| subjects | Appendicitis Appendicitis - blood Appendicitis - diagnosis Biological and medical sciences Biomarkers - blood C-Reactive Protein Calcitonin - blood Calcitonin Gene-Related Peptide Child Female Gastroenterology. Liver. Pancreas. Abdomen Humans Infectious diseases Leukocyte Count Male Medical diagnosis Medical sciences Other diseases. Semiology Protein Precursors - blood Sensitivity and Specificity Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Procalcitonin as a predictor of severe appendicitis in children |
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