Isolation and characterisation of antimicrobial peptides from deer neutrophils
The New Zealand deer industry is the largest and most advanced in the world. Antimicrobial peptides have been isolated from a wide range of organisms, but as yet there have been no reports on any from deer. This work investigates the antimicrobial activity and characterisation of peptides isolated f...
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| Veröffentlicht in: | International journal of antimicrobial agents 2005-08, Vol.26 (2), p.165-169 |
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| container_title | International journal of antimicrobial agents |
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| creator | Treffers, Charlotte Chen, Liying Anderson, Rachel C. Yu, Pak-Lam |
| description | The New Zealand deer industry is the largest and most advanced in the world. Antimicrobial peptides have been isolated from a wide range of organisms, but as yet there have been no reports on any from deer. This work investigates the antimicrobial activity and characterisation of peptides isolated from
Cervus elaphus blood. It was found that deer blood contains proline/arginine-rich cathelicidins, similar to Bac5 peptides isolated from cattle, sheep and goats. A β-defensin was also isolated that had a conserved amino acid sequence and mass similar to bovine neutrophil β-defensins. The cathelicidin displayed strong activity against Gram-negative bacteria, but lesser activity against Gram-positive bacteria and yeast, whilst the β-defensin showed good activity against all three test organisms. |
| doi_str_mv | 10.1016/j.ijantimicag.2005.05.001 |
| format | Article |
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Cervus elaphus blood. It was found that deer blood contains proline/arginine-rich cathelicidins, similar to Bac5 peptides isolated from cattle, sheep and goats. A β-defensin was also isolated that had a conserved amino acid sequence and mass similar to bovine neutrophil β-defensins. The cathelicidin displayed strong activity against Gram-negative bacteria, but lesser activity against Gram-positive bacteria and yeast, whilst the β-defensin showed good activity against all three test organisms.</description><identifier>ISSN: 0924-8579</identifier><identifier>EISSN: 1872-7913</identifier><identifier>DOI: 10.1016/j.ijantimicag.2005.05.001</identifier><identifier>PMID: 16011891</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Anti-Bacterial Agents - blood ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antimicrobial Cationic Peptides - blood ; Antimicrobial Cationic Peptides - chemistry ; Antimicrobial Cationic Peptides - isolation & purification ; Antimicrobial Cationic Peptides - pharmacology ; Antimicrobial peptides ; Bactenecins ; beta-Defensins - isolation & purification ; Biological and medical sciences ; Blood Bactericidal Activity ; Blood Proteins - chemistry ; Blood Proteins - isolation & purification ; Blood Proteins - physiology ; Cathelicidins ; Cervus elaphus ; Deer ; Defensins ; Medical sciences ; Neutrophils - chemistry ; Peptides, Cyclic - isolation & purification ; Pharmacology. Drug treatments ; β-Defensins</subject><ispartof>International journal of antimicrobial agents, 2005-08, Vol.26 (2), p.165-169</ispartof><rights>2005 Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-1e2f1aa3ec7b59647d1a109a9d96762676be05b9cfb5d04715aec2fa7ae257c23</citedby><cites>FETCH-LOGICAL-c436t-1e2f1aa3ec7b59647d1a109a9d96762676be05b9cfb5d04715aec2fa7ae257c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijantimicag.2005.05.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16995691$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16011891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Treffers, Charlotte</creatorcontrib><creatorcontrib>Chen, Liying</creatorcontrib><creatorcontrib>Anderson, Rachel C.</creatorcontrib><creatorcontrib>Yu, Pak-Lam</creatorcontrib><title>Isolation and characterisation of antimicrobial peptides from deer neutrophils</title><title>International journal of antimicrobial agents</title><addtitle>Int J Antimicrob Agents</addtitle><description>The New Zealand deer industry is the largest and most advanced in the world. Antimicrobial peptides have been isolated from a wide range of organisms, but as yet there have been no reports on any from deer. This work investigates the antimicrobial activity and characterisation of peptides isolated from
Cervus elaphus blood. It was found that deer blood contains proline/arginine-rich cathelicidins, similar to Bac5 peptides isolated from cattle, sheep and goats. A β-defensin was also isolated that had a conserved amino acid sequence and mass similar to bovine neutrophil β-defensins. The cathelicidin displayed strong activity against Gram-negative bacteria, but lesser activity against Gram-positive bacteria and yeast, whilst the β-defensin showed good activity against all three test organisms.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - blood</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimicrobial Cationic Peptides - blood</subject><subject>Antimicrobial Cationic Peptides - chemistry</subject><subject>Antimicrobial Cationic Peptides - isolation & purification</subject><subject>Antimicrobial Cationic Peptides - pharmacology</subject><subject>Antimicrobial peptides</subject><subject>Bactenecins</subject><subject>beta-Defensins - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Blood Bactericidal Activity</subject><subject>Blood Proteins - chemistry</subject><subject>Blood Proteins - isolation & purification</subject><subject>Blood Proteins - physiology</subject><subject>Cathelicidins</subject><subject>Cervus elaphus</subject><subject>Deer</subject><subject>Defensins</subject><subject>Medical sciences</subject><subject>Neutrophils - chemistry</subject><subject>Peptides, Cyclic - isolation & purification</subject><subject>Pharmacology. 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Cervus elaphus blood. It was found that deer blood contains proline/arginine-rich cathelicidins, similar to Bac5 peptides isolated from cattle, sheep and goats. A β-defensin was also isolated that had a conserved amino acid sequence and mass similar to bovine neutrophil β-defensins. The cathelicidin displayed strong activity against Gram-negative bacteria, but lesser activity against Gram-positive bacteria and yeast, whilst the β-defensin showed good activity against all three test organisms.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>16011891</pmid><doi>10.1016/j.ijantimicag.2005.05.001</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Anti-Bacterial Agents - blood Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial Cationic Peptides - blood Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - isolation & purification Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptides Bactenecins beta-Defensins - isolation & purification Biological and medical sciences Blood Bactericidal Activity Blood Proteins - chemistry Blood Proteins - isolation & purification Blood Proteins - physiology Cathelicidins Cervus elaphus Deer Defensins Medical sciences Neutrophils - chemistry Peptides, Cyclic - isolation & purification Pharmacology. Drug treatments β-Defensins |
| title | Isolation and characterisation of antimicrobial peptides from deer neutrophils |
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