Severe Sepsis and Septic Shock: Review of the Literature and Emergency Department Management Guidelines

Severe sepsis and septic shock are as common and lethal as other acute life-threatening conditions that emergency physicians routinely confront such as acute myocardial infarction, stroke, and trauma. Recent studies have led to a better understanding of the pathogenic mechanisms and the development...

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Veröffentlicht in:Annals of emergency medicine 2006-07, Vol.48 (1), p.54.e1-54.e1
Hauptverfasser: Nguyen, H. Bryant, Rivers, Emanuel P., Abrahamian, Fredrick M., Moran, Gregory J., Abraham, Edward, Trzeciak, Stephen, Huang, David T., Osborn, Tiffany, Stevens, Dennis, Talan, David A.
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container_title Annals of emergency medicine
container_volume 48
creator Nguyen, H. Bryant
Rivers, Emanuel P.
Abrahamian, Fredrick M.
Moran, Gregory J.
Abraham, Edward
Trzeciak, Stephen
Huang, David T.
Osborn, Tiffany
Stevens, Dennis
Talan, David A.
description Severe sepsis and septic shock are as common and lethal as other acute life-threatening conditions that emergency physicians routinely confront such as acute myocardial infarction, stroke, and trauma. Recent studies have led to a better understanding of the pathogenic mechanisms and the development of new or newly applied therapies. These therapies place early and aggressive management of severe sepsis and septic shock as integral to improving outcome. This independent review of the literature examines the recent pathogenic, diagnostic, and therapeutic advances in severe sepsis and septic shock for adults, with particular relevance to emergency practice. Recommendations are provided for therapies that have been shown to improve outcomes, including early goal-directed therapy, early and appropriate antimicrobials, source control, recombinant human activated protein C, corticosteroids, and low tidal volume mechanical ventilation.
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subjects Adrenal Cortex Hormones - therapeutic use
Algorithms
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anti-Bacterial Agents - therapeutic use
Biological and medical sciences
Cardiovascular Agents - therapeutic use
Drug Therapy, Combination
Emergency and intensive care: infection, septic shock
Emergency and intensive care: techniques, logistics
Humans
Intensive care medicine
Intensive care unit. Emergency transport systems. Emergency, hospital ward
Medical sciences
Practice Guidelines as Topic
Protein C - therapeutic use
Recombinant Proteins - therapeutic use
Respiration, Artificial
Sepsis - diagnosis
Sepsis - epidemiology
Sepsis - etiology
Sepsis - therapy
Shock, Septic - therapy
title Severe Sepsis and Septic Shock: Review of the Literature and Emergency Department Management Guidelines
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