Severe Sepsis and Septic Shock: Review of the Literature and Emergency Department Management Guidelines
Severe sepsis and septic shock are as common and lethal as other acute life-threatening conditions that emergency physicians routinely confront such as acute myocardial infarction, stroke, and trauma. Recent studies have led to a better understanding of the pathogenic mechanisms and the development...
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Veröffentlicht in: | Annals of emergency medicine 2006-07, Vol.48 (1), p.54.e1-54.e1 |
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container_title | Annals of emergency medicine |
container_volume | 48 |
creator | Nguyen, H. Bryant Rivers, Emanuel P. Abrahamian, Fredrick M. Moran, Gregory J. Abraham, Edward Trzeciak, Stephen Huang, David T. Osborn, Tiffany Stevens, Dennis Talan, David A. |
description | Severe sepsis and septic shock are as common and lethal as other acute life-threatening conditions that emergency physicians routinely confront such as acute myocardial infarction, stroke, and trauma. Recent studies have led to a better understanding of the pathogenic mechanisms and the development of new or newly applied therapies. These therapies place early and aggressive management of severe sepsis and septic shock as integral to improving outcome. This independent review of the literature examines the recent pathogenic, diagnostic, and therapeutic advances in severe sepsis and septic shock for adults, with particular relevance to emergency practice. Recommendations are provided for therapies that have been shown to improve outcomes, including early goal-directed therapy, early and appropriate antimicrobials, source control, recombinant human activated protein C, corticosteroids, and low tidal volume mechanical ventilation. |
doi_str_mv | 10.1016/j.annemergmed.2006.02.015 |
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Bryant ; Rivers, Emanuel P. ; Abrahamian, Fredrick M. ; Moran, Gregory J. ; Abraham, Edward ; Trzeciak, Stephen ; Huang, David T. ; Osborn, Tiffany ; Stevens, Dennis ; Talan, David A.</creator><creatorcontrib>Nguyen, H. Bryant ; Rivers, Emanuel P. ; Abrahamian, Fredrick M. ; Moran, Gregory J. ; Abraham, Edward ; Trzeciak, Stephen ; Huang, David T. ; Osborn, Tiffany ; Stevens, Dennis ; Talan, David A. ; Emergency Department Sepsis Education Program and Strategies to Improve Survival (ED-SEPSIS) Working Group</creatorcontrib><description>Severe sepsis and septic shock are as common and lethal as other acute life-threatening conditions that emergency physicians routinely confront such as acute myocardial infarction, stroke, and trauma. Recent studies have led to a better understanding of the pathogenic mechanisms and the development of new or newly applied therapies. These therapies place early and aggressive management of severe sepsis and septic shock as integral to improving outcome. This independent review of the literature examines the recent pathogenic, diagnostic, and therapeutic advances in severe sepsis and septic shock for adults, with particular relevance to emergency practice. Recommendations are provided for therapies that have been shown to improve outcomes, including early goal-directed therapy, early and appropriate antimicrobials, source control, recombinant human activated protein C, corticosteroids, and low tidal volume mechanical ventilation.</description><identifier>ISSN: 0196-0644</identifier><identifier>EISSN: 1097-6760</identifier><identifier>DOI: 10.1016/j.annemergmed.2006.02.015</identifier><identifier>PMID: 16781920</identifier><identifier>CODEN: AEMED3</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adrenal Cortex Hormones - therapeutic use ; Algorithms ; Anesthesia. Intensive care medicine. Transfusions. 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Recent studies have led to a better understanding of the pathogenic mechanisms and the development of new or newly applied therapies. These therapies place early and aggressive management of severe sepsis and septic shock as integral to improving outcome. This independent review of the literature examines the recent pathogenic, diagnostic, and therapeutic advances in severe sepsis and septic shock for adults, with particular relevance to emergency practice. Recommendations are provided for therapies that have been shown to improve outcomes, including early goal-directed therapy, early and appropriate antimicrobials, source control, recombinant human activated protein C, corticosteroids, and low tidal volume mechanical ventilation.</description><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Algorithms</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular Agents - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Emergency and intensive care: infection, septic shock</subject><subject>Emergency and intensive care: techniques, logistics</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Intensive care unit. Emergency transport systems. Emergency, hospital ward</subject><subject>Medical sciences</subject><subject>Practice Guidelines as Topic</subject><subject>Protein C - therapeutic use</subject><subject>Recombinant Proteins - therapeutic use</subject><subject>Respiration, Artificial</subject><subject>Sepsis - diagnosis</subject><subject>Sepsis - epidemiology</subject><subject>Sepsis - etiology</subject><subject>Sepsis - therapy</subject><subject>Shock, Septic - therapy</subject><issn>0196-0644</issn><issn>1097-6760</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUGP0zAQhS0EYsvCX0DmALeEsZs4MTfUXRakIiQKZ8uxJ12XxCm2s2j_PQ6tgOOePPJ8b2b0HiGvGJQMmHh7KLX3OGLYj2hLDiBK4CWw-hFZMZBNIRoBj8kKmBQFiKq6IM9iPACArDh7Si6YaFomOazIfod3GJDu8BhdpNrbpUzO0N3tZH68o1_xzuEvOvU03SLduoRBpzkrFvR6uQG9uadXeNQhjegT_ay93uOf8mZ2FgfnMT4nT3o9RHxxfi_J9w_X3zYfi-2Xm0-b99vC1A1PRdNbIQU2lbHaaiFN29mmM3y9NrVtBZda2M52om5bmf-NsetOiA761tTQM7m-JG9Oc49h-jljTGp00eAwaI_THJVooWX8AWC2R1ZQVxmUJ9CEKcaAvToGN-pwrxioJQ51UP_FoZY4FHCV48jal-clc7f0_irP_mfg9RnQ0eihD9obF_9xjWQVEwu3OXGYvcuBBBWNy8ajdQFNUnZyDzjnN31dsB4</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>Nguyen, H. 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subjects | Adrenal Cortex Hormones - therapeutic use Algorithms Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anti-Bacterial Agents - therapeutic use Biological and medical sciences Cardiovascular Agents - therapeutic use Drug Therapy, Combination Emergency and intensive care: infection, septic shock Emergency and intensive care: techniques, logistics Humans Intensive care medicine Intensive care unit. Emergency transport systems. Emergency, hospital ward Medical sciences Practice Guidelines as Topic Protein C - therapeutic use Recombinant Proteins - therapeutic use Respiration, Artificial Sepsis - diagnosis Sepsis - epidemiology Sepsis - etiology Sepsis - therapy Shock, Septic - therapy |
title | Severe Sepsis and Septic Shock: Review of the Literature and Emergency Department Management Guidelines |
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