Neural correlates of genetically abnormal social cognition in Williams syndrome
Williams-Beuren syndrome (WBS), caused by a microdeletion of approximately 21 genes on chromosome 7q11.23, is characterized by unique hypersociability combined with increased non-social anxiety. Using functional neuroimaging, we found reduced amygdala activation in individuals with WBS for threateni...
Gespeichert in:
| Veröffentlicht in: | Nature neuroscience 2005-08, Vol.8 (8), p.991-993 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 993 |
|---|---|
| container_issue | 8 |
| container_start_page | 991 |
| container_title | Nature neuroscience |
| container_volume | 8 |
| creator | Meyer-Lindenberg, Andreas Hariri, Ahmad R Munoz, Karen E Mervis, Carolyn B Mattay, Venkata S Morris, Colleen A Berman, Karen Faith |
| description | Williams-Beuren syndrome (WBS), caused by a microdeletion of approximately 21 genes on chromosome 7q11.23, is characterized by unique hypersociability combined with increased non-social anxiety. Using functional neuroimaging, we found reduced amygdala activation in individuals with WBS for threatening faces but increased activation for threatening scenes, relative to matched normal controls. Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior. |
| doi_str_mv | 10.1038/nn1494 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_68080910</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A185538757</galeid><sourcerecordid>A185538757</sourcerecordid><originalsourceid>FETCH-LOGICAL-c495t-123c254cc305c0fba39c160551e97654cf6e08e906a8ed24cec30f81b49bb2873</originalsourceid><addsrcrecordid>eNqF0UFLHDEUAOBQKlXX9heUMngQepg1mUkyyXERbQVRsC0eQyb7ZolkEptkwP33xu5g0YvkkEfyvfDyHkJfCF4S3IpT7wmV9AM6IIzymnQN_1hiLLuaN4zvo8OU7jHGHRPyE9onvIRY0AN0cw1T1K4yIUZwOkOqwlBtwEO2Rju3rXTvQxwLScHYf3LjbbbBV9ZXd9Y5q8dUpa1fxzDCEdobtEvwed4X6M_F-e-zn_XVzY_Ls9VVbahkuSZNaxpGjWkxM3jodStNKYoxArLj5WLggAVIzLWAdUMNFDkI0lPZ943o2gU62b37EMPfCVJWo00GnNMewpQUF1hgWVrzHiSlD0SItsDjN_A-TNGXT6imo1Rg3pCClju00Q6U9UPIUZuy1jBaEzwMtpyviGCsFR17rvP7q4RiMjzmjZ5SUpe_bl_buVQTQ0oRBvUQ7ajjVhGsnqesdlMu8Ntc6tSPsP7P5rEW8HUHvM5ThBcw5z8BaiGpuQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>274480621</pqid></control><display><type>article</type><title>Neural correlates of genetically abnormal social cognition in Williams syndrome</title><source>MEDLINE</source><source>Nature Journals Online</source><source>Alma/SFX Local Collection</source><creator>Meyer-Lindenberg, Andreas ; Hariri, Ahmad R ; Munoz, Karen E ; Mervis, Carolyn B ; Mattay, Venkata S ; Morris, Colleen A ; Berman, Karen Faith</creator><creatorcontrib>Meyer-Lindenberg, Andreas ; Hariri, Ahmad R ; Munoz, Karen E ; Mervis, Carolyn B ; Mattay, Venkata S ; Morris, Colleen A ; Berman, Karen Faith</creatorcontrib><description>Williams-Beuren syndrome (WBS), caused by a microdeletion of approximately 21 genes on chromosome 7q11.23, is characterized by unique hypersociability combined with increased non-social anxiety. Using functional neuroimaging, we found reduced amygdala activation in individuals with WBS for threatening faces but increased activation for threatening scenes, relative to matched normal controls. Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior.</description><identifier>ISSN: 1097-6256</identifier><identifier>EISSN: 1546-1726</identifier><identifier>DOI: 10.1038/nn1494</identifier><identifier>PMID: 16007084</identifier><identifier>CODEN: NANEFN</identifier><language>eng</language><publisher>United States: Nature Publishing Group</publisher><subject>Amygdala (Brain) ; Amygdala - physiopathology ; Anxiety - physiopathology ; Brain - physiopathology ; Brain Mapping ; Case-Control Studies ; Cognition ; Cognition & reasoning ; Diagnosis ; Fear & phobias ; Frontal Lobe - physiopathology ; Genetic aspects ; Genotype & phenotype ; Humans ; Magnetic Resonance Imaging ; Medical imaging ; Neuroimaging ; Neurosciences ; Physiological aspects ; Prefrontal Cortex - physiopathology ; Social Behavior ; Williams syndrome ; Williams Syndrome - physiopathology ; Williams Syndrome - psychology</subject><ispartof>Nature neuroscience, 2005-08, Vol.8 (8), p.991-993</ispartof><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-123c254cc305c0fba39c160551e97654cf6e08e906a8ed24cec30f81b49bb2873</citedby><cites>FETCH-LOGICAL-c495t-123c254cc305c0fba39c160551e97654cf6e08e906a8ed24cec30f81b49bb2873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2728,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16007084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meyer-Lindenberg, Andreas</creatorcontrib><creatorcontrib>Hariri, Ahmad R</creatorcontrib><creatorcontrib>Munoz, Karen E</creatorcontrib><creatorcontrib>Mervis, Carolyn B</creatorcontrib><creatorcontrib>Mattay, Venkata S</creatorcontrib><creatorcontrib>Morris, Colleen A</creatorcontrib><creatorcontrib>Berman, Karen Faith</creatorcontrib><title>Neural correlates of genetically abnormal social cognition in Williams syndrome</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><description>Williams-Beuren syndrome (WBS), caused by a microdeletion of approximately 21 genes on chromosome 7q11.23, is characterized by unique hypersociability combined with increased non-social anxiety. Using functional neuroimaging, we found reduced amygdala activation in individuals with WBS for threatening faces but increased activation for threatening scenes, relative to matched normal controls. Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior.</description><subject>Amygdala (Brain)</subject><subject>Amygdala - physiopathology</subject><subject>Anxiety - physiopathology</subject><subject>Brain - physiopathology</subject><subject>Brain Mapping</subject><subject>Case-Control Studies</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Diagnosis</subject><subject>Fear & phobias</subject><subject>Frontal Lobe - physiopathology</subject><subject>Genetic aspects</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical imaging</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Physiological aspects</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Social Behavior</subject><subject>Williams syndrome</subject><subject>Williams Syndrome - physiopathology</subject><subject>Williams Syndrome - psychology</subject><issn>1097-6256</issn><issn>1546-1726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0UFLHDEUAOBQKlXX9heUMngQepg1mUkyyXERbQVRsC0eQyb7ZolkEptkwP33xu5g0YvkkEfyvfDyHkJfCF4S3IpT7wmV9AM6IIzymnQN_1hiLLuaN4zvo8OU7jHGHRPyE9onvIRY0AN0cw1T1K4yIUZwOkOqwlBtwEO2Rju3rXTvQxwLScHYf3LjbbbBV9ZXd9Y5q8dUpa1fxzDCEdobtEvwed4X6M_F-e-zn_XVzY_Ls9VVbahkuSZNaxpGjWkxM3jodStNKYoxArLj5WLggAVIzLWAdUMNFDkI0lPZ943o2gU62b37EMPfCVJWo00GnNMewpQUF1hgWVrzHiSlD0SItsDjN_A-TNGXT6imo1Rg3pCClju00Q6U9UPIUZuy1jBaEzwMtpyviGCsFR17rvP7q4RiMjzmjZ5SUpe_bl_buVQTQ0oRBvUQ7ajjVhGsnqesdlMu8Ntc6tSPsP7P5rEW8HUHvM5ThBcw5z8BaiGpuQ</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Meyer-Lindenberg, Andreas</creator><creator>Hariri, Ahmad R</creator><creator>Munoz, Karen E</creator><creator>Mervis, Carolyn B</creator><creator>Mattay, Venkata S</creator><creator>Morris, Colleen A</creator><creator>Berman, Karen Faith</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Neural correlates of genetically abnormal social cognition in Williams syndrome</title><author>Meyer-Lindenberg, Andreas ; Hariri, Ahmad R ; Munoz, Karen E ; Mervis, Carolyn B ; Mattay, Venkata S ; Morris, Colleen A ; Berman, Karen Faith</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-123c254cc305c0fba39c160551e97654cf6e08e906a8ed24cec30f81b49bb2873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amygdala (Brain)</topic><topic>Amygdala - physiopathology</topic><topic>Anxiety - physiopathology</topic><topic>Brain - physiopathology</topic><topic>Brain Mapping</topic><topic>Case-Control Studies</topic><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Diagnosis</topic><topic>Fear & phobias</topic><topic>Frontal Lobe - physiopathology</topic><topic>Genetic aspects</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical imaging</topic><topic>Neuroimaging</topic><topic>Neurosciences</topic><topic>Physiological aspects</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Social Behavior</topic><topic>Williams syndrome</topic><topic>Williams Syndrome - physiopathology</topic><topic>Williams Syndrome - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meyer-Lindenberg, Andreas</creatorcontrib><creatorcontrib>Hariri, Ahmad R</creatorcontrib><creatorcontrib>Munoz, Karen E</creatorcontrib><creatorcontrib>Mervis, Carolyn B</creatorcontrib><creatorcontrib>Mattay, Venkata S</creatorcontrib><creatorcontrib>Morris, Colleen A</creatorcontrib><creatorcontrib>Berman, Karen Faith</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meyer-Lindenberg, Andreas</au><au>Hariri, Ahmad R</au><au>Munoz, Karen E</au><au>Mervis, Carolyn B</au><au>Mattay, Venkata S</au><au>Morris, Colleen A</au><au>Berman, Karen Faith</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural correlates of genetically abnormal social cognition in Williams syndrome</atitle><jtitle>Nature neuroscience</jtitle><addtitle>Nat Neurosci</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>8</volume><issue>8</issue><spage>991</spage><epage>993</epage><pages>991-993</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><coden>NANEFN</coden><abstract>Williams-Beuren syndrome (WBS), caused by a microdeletion of approximately 21 genes on chromosome 7q11.23, is characterized by unique hypersociability combined with increased non-social anxiety. Using functional neuroimaging, we found reduced amygdala activation in individuals with WBS for threatening faces but increased activation for threatening scenes, relative to matched normal controls. Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior.</abstract><cop>United States</cop><pub>Nature Publishing Group</pub><pmid>16007084</pmid><doi>10.1038/nn1494</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1097-6256 |
| ispartof | Nature neuroscience, 2005-08, Vol.8 (8), p.991-993 |
| issn | 1097-6256 1546-1726 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68080910 |
| source | MEDLINE; Nature Journals Online; Alma/SFX Local Collection |
| subjects | Amygdala (Brain) Amygdala - physiopathology Anxiety - physiopathology Brain - physiopathology Brain Mapping Case-Control Studies Cognition Cognition & reasoning Diagnosis Fear & phobias Frontal Lobe - physiopathology Genetic aspects Genotype & phenotype Humans Magnetic Resonance Imaging Medical imaging Neuroimaging Neurosciences Physiological aspects Prefrontal Cortex - physiopathology Social Behavior Williams syndrome Williams Syndrome - physiopathology Williams Syndrome - psychology |
| title | Neural correlates of genetically abnormal social cognition in Williams syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T09%3A11%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neural%20correlates%20of%20genetically%20abnormal%20social%20cognition%20in%20Williams%20syndrome&rft.jtitle=Nature%20neuroscience&rft.au=Meyer-Lindenberg,%20Andreas&rft.date=2005-08-01&rft.volume=8&rft.issue=8&rft.spage=991&rft.epage=993&rft.pages=991-993&rft.issn=1097-6256&rft.eissn=1546-1726&rft.coden=NANEFN&rft_id=info:doi/10.1038/nn1494&rft_dat=%3Cgale_proqu%3EA185538757%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=274480621&rft_id=info:pmid/16007084&rft_galeid=A185538757&rfr_iscdi=true |