The ambient pH response Rim pathway in Yarrowia lipolytica: identification of YlRIM9 and characterization of its role in dimorphism
Yarrowia lipolytica is a dimorphic fungus that secretes either an acidic or an alkaline protease depending on the environmental pH. Previous results have indicated that secretion of the alkaline protease is under control of the pH signaling Pal/Rim pathway originally described in Aspergillus nidulan...
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| Veröffentlicht in: | Current microbiology 2006-07, Vol.53 (1), p.8-12 |
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| creator | González-López, Claudia Isela Ortiz-Castellanos, Lucila Ruiz-Herrera, José |
| description | Yarrowia lipolytica is a dimorphic fungus that secretes either an acidic or an alkaline protease depending on the environmental pH. Previous results have indicated that secretion of the alkaline protease is under control of the pH signaling Pal/Rim pathway originally described in Aspergillus nidulans. Several Y. lipolytica mutants defective in some Rim components of this pathway have been previously isolated and the RIM genes characterized. In the present study, Y. lipolytica RIM9 (palI) gene (YlRIM9) was sequenced from a plasmid (AL414126) of the Genolevures project (the DNA sequence data for YlRIM9 gene has been deposited at EMBL with accession number AJ566902). The derived translation product contains 724 amino acids with a predicted signal peptide and four transmembrane domains in its N-terminal region. We demonstrated that mutation in YlRIM9, as well as in other genes encoding members of the Pal/Rim pathway, did not affect the pH-dependent dimorphic transition of Y. lipolytica. A different pathway must exist in this fungus that controls the effect of pH on dimorphism. |
| doi_str_mv | 10.1007/s00284-005-0070-6 |
| format | Article |
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Previous results have indicated that secretion of the alkaline protease is under control of the pH signaling Pal/Rim pathway originally described in Aspergillus nidulans. Several Y. lipolytica mutants defective in some Rim components of this pathway have been previously isolated and the RIM genes characterized. In the present study, Y. lipolytica RIM9 (palI) gene (YlRIM9) was sequenced from a plasmid (AL414126) of the Genolevures project (the DNA sequence data for YlRIM9 gene has been deposited at EMBL with accession number AJ566902). The derived translation product contains 724 amino acids with a predicted signal peptide and four transmembrane domains in its N-terminal region. We demonstrated that mutation in YlRIM9, as well as in other genes encoding members of the Pal/Rim pathway, did not affect the pH-dependent dimorphic transition of Y. lipolytica. A different pathway must exist in this fungus that controls the effect of pH on dimorphism.</description><identifier>ISSN: 0343-8651</identifier><identifier>EISSN: 1432-0991</identifier><identifier>DOI: 10.1007/s00284-005-0070-6</identifier><identifier>PMID: 16775780</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Amino acids ; Aspergillus nidulans ; Fungal Proteins - genetics ; Fungal Proteins - metabolism ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Fungal ; Hydrogen-Ion Concentration ; Molecular Sequence Data ; Mycelium - genetics ; Mycelium - growth & development ; Mycelium - metabolism ; Proteins ; Sequence Analysis, DNA ; Signal Transduction ; Yarrowia - genetics ; Yarrowia - growth & development ; Yarrowia - metabolism ; Yarrowia lipolytica</subject><ispartof>Current microbiology, 2006-07, Vol.53 (1), p.8-12</ispartof><rights>Springer Science+Business Media, Inc. 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-110fb424c76ab9a3db48d288c6f9a45e3850b99a501c628b1bcb7f8cf38add313</citedby><cites>FETCH-LOGICAL-c357t-110fb424c76ab9a3db48d288c6f9a45e3850b99a501c628b1bcb7f8cf38add313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16775780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González-López, Claudia Isela</creatorcontrib><creatorcontrib>Ortiz-Castellanos, Lucila</creatorcontrib><creatorcontrib>Ruiz-Herrera, José</creatorcontrib><title>The ambient pH response Rim pathway in Yarrowia lipolytica: identification of YlRIM9 and characterization of its role in dimorphism</title><title>Current microbiology</title><addtitle>Curr Microbiol</addtitle><description>Yarrowia lipolytica is a dimorphic fungus that secretes either an acidic or an alkaline protease depending on the environmental pH. Previous results have indicated that secretion of the alkaline protease is under control of the pH signaling Pal/Rim pathway originally described in Aspergillus nidulans. Several Y. lipolytica mutants defective in some Rim components of this pathway have been previously isolated and the RIM genes characterized. In the present study, Y. lipolytica RIM9 (palI) gene (YlRIM9) was sequenced from a plasmid (AL414126) of the Genolevures project (the DNA sequence data for YlRIM9 gene has been deposited at EMBL with accession number AJ566902). The derived translation product contains 724 amino acids with a predicted signal peptide and four transmembrane domains in its N-terminal region. We demonstrated that mutation in YlRIM9, as well as in other genes encoding members of the Pal/Rim pathway, did not affect the pH-dependent dimorphic transition of Y. lipolytica. A different pathway must exist in this fungus that controls the effect of pH on dimorphism.</description><subject>Amino acids</subject><subject>Aspergillus nidulans</subject><subject>Fungal Proteins - genetics</subject><subject>Fungal Proteins - metabolism</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gene Expression Regulation, Fungal</subject><subject>Hydrogen-Ion Concentration</subject><subject>Molecular Sequence Data</subject><subject>Mycelium - genetics</subject><subject>Mycelium - growth & development</subject><subject>Mycelium - metabolism</subject><subject>Proteins</subject><subject>Sequence Analysis, DNA</subject><subject>Signal Transduction</subject><subject>Yarrowia - genetics</subject><subject>Yarrowia - growth & development</subject><subject>Yarrowia - metabolism</subject><subject>Yarrowia lipolytica</subject><issn>0343-8651</issn><issn>1432-0991</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1r3DAQhkVJabZpf0AvQeTQm9sZy9ZHbiGkTSClENJDTkKSZVbBthzJS9he-8erZZcUculh0ICe94HhJeQTwhcEEF8zQC2bCqAtI6Dib8gKG1ZXoBQekRWwhlWSt3hM3uf8CIC1AnxHjpEL0QoJK_Lnfu2pGW3w00Lna5p8nuOUPb0LI53Nsn42Wxom-mBSis_B0CHMcdguwZlzGrqSCn3ZlxAnGnv6MNzd_FDUTB11a5OMW3wKv1--w5JpioPfGbswxjSvQx4_kLe9GbL_eHhPyK9vV_eX19Xtz-83lxe3lWOtWCpE6G1TN05wY5VhnW1kV0vpeK9M03omW7BKmRbQ8VpatM6KXrqeSdN1DNkJ-bz3zik-bXxe9Biy88NgJh83WXMJQhXhf0FUjSrgznj2CnyMmzSVI7RQnHFkdVsg3EMuxZyT7_WcwmjSViPoXY9636MuPepdj5qXzOlBvLGj7_4lDsWxv4kTmak</recordid><startdate>200607</startdate><enddate>200607</enddate><creator>González-López, Claudia Isela</creator><creator>Ortiz-Castellanos, Lucila</creator><creator>Ruiz-Herrera, José</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200607</creationdate><title>The ambient pH response Rim pathway in Yarrowia lipolytica: identification of YlRIM9 and characterization of its role in dimorphism</title><author>González-López, Claudia Isela ; Ortiz-Castellanos, Lucila ; Ruiz-Herrera, José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-110fb424c76ab9a3db48d288c6f9a45e3850b99a501c628b1bcb7f8cf38add313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Amino acids</topic><topic>Aspergillus nidulans</topic><topic>Fungal Proteins - genetics</topic><topic>Fungal Proteins - metabolism</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Gene Expression Regulation, Fungal</topic><topic>Hydrogen-Ion Concentration</topic><topic>Molecular Sequence Data</topic><topic>Mycelium - genetics</topic><topic>Mycelium - growth & development</topic><topic>Mycelium - metabolism</topic><topic>Proteins</topic><topic>Sequence Analysis, DNA</topic><topic>Signal Transduction</topic><topic>Yarrowia - genetics</topic><topic>Yarrowia - growth & development</topic><topic>Yarrowia - metabolism</topic><topic>Yarrowia lipolytica</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González-López, Claudia Isela</creatorcontrib><creatorcontrib>Ortiz-Castellanos, Lucila</creatorcontrib><creatorcontrib>Ruiz-Herrera, José</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González-López, Claudia Isela</au><au>Ortiz-Castellanos, Lucila</au><au>Ruiz-Herrera, José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ambient pH response Rim pathway in Yarrowia lipolytica: identification of YlRIM9 and characterization of its role in dimorphism</atitle><jtitle>Current microbiology</jtitle><addtitle>Curr Microbiol</addtitle><date>2006-07</date><risdate>2006</risdate><volume>53</volume><issue>1</issue><spage>8</spage><epage>12</epage><pages>8-12</pages><issn>0343-8651</issn><eissn>1432-0991</eissn><abstract>Yarrowia lipolytica is a dimorphic fungus that secretes either an acidic or an alkaline protease depending on the environmental pH. Previous results have indicated that secretion of the alkaline protease is under control of the pH signaling Pal/Rim pathway originally described in Aspergillus nidulans. Several Y. lipolytica mutants defective in some Rim components of this pathway have been previously isolated and the RIM genes characterized. In the present study, Y. lipolytica RIM9 (palI) gene (YlRIM9) was sequenced from a plasmid (AL414126) of the Genolevures project (the DNA sequence data for YlRIM9 gene has been deposited at EMBL with accession number AJ566902). The derived translation product contains 724 amino acids with a predicted signal peptide and four transmembrane domains in its N-terminal region. We demonstrated that mutation in YlRIM9, as well as in other genes encoding members of the Pal/Rim pathway, did not affect the pH-dependent dimorphic transition of Y. lipolytica. A different pathway must exist in this fungus that controls the effect of pH on dimorphism.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>16775780</pmid><doi>10.1007/s00284-005-0070-6</doi><tpages>5</tpages></addata></record> |
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| ispartof | Current microbiology, 2006-07, Vol.53 (1), p.8-12 |
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| subjects | Amino acids Aspergillus nidulans Fungal Proteins - genetics Fungal Proteins - metabolism Gene Expression Regulation, Developmental Gene Expression Regulation, Fungal Hydrogen-Ion Concentration Molecular Sequence Data Mycelium - genetics Mycelium - growth & development Mycelium - metabolism Proteins Sequence Analysis, DNA Signal Transduction Yarrowia - genetics Yarrowia - growth & development Yarrowia - metabolism Yarrowia lipolytica |
| title | The ambient pH response Rim pathway in Yarrowia lipolytica: identification of YlRIM9 and characterization of its role in dimorphism |
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