Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro

Adult mesenchymal stem cells (MSCs) have the capacity to differentiate into various connective tissues such as cartilage and bone following stimulation with certain growth factors. However, less is known about the capacity of these cells to undergo chondrogenesis when these proteins are delivered vi...

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Veröffentlicht in:	Molecular therapy 2005-08, Vol.12 (2), p.219-228
Hauptverfasser:	Palmer, Glyn D, Steinert, Andre, Pascher, Arnulf, Gouze, Elvire, Gouze, Jean-Noel, Betz, Oliver, Johnstone, Brian, Evans, Christopher H, Ghivizzani, Steven C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adenoviruses Adult Aggregates Bone marrow Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins - metabolism Cartilage Cell Differentiation Chondrocytes Chondrogenesis - genetics Chondrogenesis - physiology Culture Techniques Experiments Gene Expression Gene therapy Gene Transfer Techniques Genetic Therapy Genetic Vectors Humans Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Mesenchymal Stromal Cells - physiology Orthopedics Osteogenesis Proteins Stem cells Tissue Engineering - methods Transforming Growth Factor beta - metabolism Transforming Growth Factor beta1 Transgenes - genetics
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