A case of rhesus hemolytic disease with hemophagocytosis and severe iron overload due to multiple transfusions
A newborn with cholestatic hepatic disease and hemophagocytic lymphohistiocytosis due to rhesus hemolytic disease (RHD) is reported. A 34 weeks' gestation baby with RHD, who had received multiple intrauterine transfusions (IUT), developed cholestatic hepatic disease and secondary hemophagocytic...
Gespeichert in:
| Veröffentlicht in: | Journal of pediatric hematology/oncology 2006-05, Vol.28 (5), p.290-292 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 292 |
|---|---|
| container_issue | 5 |
| container_start_page | 290 |
| container_title | Journal of pediatric hematology/oncology |
| container_volume | 28 |
| creator | Yilmaz, Sebnem Duman, Nuray Ozer, Esra Kavas, Nazan Oren, Hale Demircioğlu, Fatih Kumral, Abdullah Ozkan, Hasan Irken, Gülersu Ozer, Erdener |
| description | A newborn with cholestatic hepatic disease and hemophagocytic lymphohistiocytosis due to rhesus hemolytic disease (RHD) is reported.
A 34 weeks' gestation baby with RHD, who had received multiple intrauterine transfusions (IUT), developed cholestatic hepatic disease and secondary hemophagocytic lymphohistiocytosis (HLH). Her serum ferritin level increased to 5,527 ng/mL, and liver biopsy showed severe iron overload. Treatment with intravenous desferrioxamine resulted in a marked decrease in serum ferritin levels and normalization of liver function
We suggest that patients who have undergone IUT be evaluated for hyperferritinemia. If hyperferritinemia is noted, chelation therapy should be considered. As another rare finding, HLH can complicate the course of RHD. |
| doi_str_mv | 10.1097/01.mph.0000212906.07018.93 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68077807</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68077807</sourcerecordid><originalsourceid>FETCH-LOGICAL-c317t-f18c4f4226976afa80c199bb44e1da126ae24a169ce419c4f0ae7a2095474e3f3</originalsourceid><addsrcrecordid>eNpFkF1LxTAMhnuh-P0XpHjh3ZlNV9fVOxG_QPBGr0tPl7nKts5mU86_t-oBAyEhed8EHsbOQBQgjL4QUAxTV4gcEqQRVSG0gLow5Q47AKH1SgGofXZI9C4E6FLJPbYPlday1vUBG6-5d4Q8tjx1SAvxDofYb-bgeRMIf3ZfYe5-x1Pn3qLfzJECcTc2nPATE_KQ4shjbvvoGt4syOfIh6Wfw9TnPrmR2oVCHOmY7bauJzzZ1iP2enf7cvOwenq-f7y5flr5EvS8aqH2qlVSVkZXrnW18GDMeq0UQuNAVg6lclAZjwpMlgqH2klhLpVWWLblETv_uzul-LEgzXYI5LHv3YhxIVvVGU3OLLz6E_oUiRK2dkphcGljQdgfwlaAzYTtP2H7S9iaMptPt1-W9YDNv3WLt_wG9Lt8sQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68077807</pqid></control><display><type>article</type><title>A case of rhesus hemolytic disease with hemophagocytosis and severe iron overload due to multiple transfusions</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Yilmaz, Sebnem ; Duman, Nuray ; Ozer, Esra ; Kavas, Nazan ; Oren, Hale ; Demircioğlu, Fatih ; Kumral, Abdullah ; Ozkan, Hasan ; Irken, Gülersu ; Ozer, Erdener</creator><creatorcontrib>Yilmaz, Sebnem ; Duman, Nuray ; Ozer, Esra ; Kavas, Nazan ; Oren, Hale ; Demircioğlu, Fatih ; Kumral, Abdullah ; Ozkan, Hasan ; Irken, Gülersu ; Ozer, Erdener</creatorcontrib><description>A newborn with cholestatic hepatic disease and hemophagocytic lymphohistiocytosis due to rhesus hemolytic disease (RHD) is reported.
A 34 weeks' gestation baby with RHD, who had received multiple intrauterine transfusions (IUT), developed cholestatic hepatic disease and secondary hemophagocytic lymphohistiocytosis (HLH). Her serum ferritin level increased to 5,527 ng/mL, and liver biopsy showed severe iron overload. Treatment with intravenous desferrioxamine resulted in a marked decrease in serum ferritin levels and normalization of liver function
We suggest that patients who have undergone IUT be evaluated for hyperferritinemia. If hyperferritinemia is noted, chelation therapy should be considered. As another rare finding, HLH can complicate the course of RHD.</description><identifier>ISSN: 1077-4114</identifier><identifier>DOI: 10.1097/01.mph.0000212906.07018.93</identifier><identifier>PMID: 16772878</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Anemia, Hemolytic, Autoimmune - complications ; Anemia, Hemolytic, Autoimmune - therapy ; Cholestasis, Intrahepatic - etiology ; Cholestasis, Intrahepatic - therapy ; Deferoxamine - therapeutic use ; Female ; Humans ; Infant, Newborn ; Iron Overload - etiology ; Iron Overload - therapy ; Lymphohistiocytosis, Hemophagocytic - etiology ; Lymphohistiocytosis, Hemophagocytic - therapy ; Transfusion Reaction</subject><ispartof>Journal of pediatric hematology/oncology, 2006-05, Vol.28 (5), p.290-292</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-f18c4f4226976afa80c199bb44e1da126ae24a169ce419c4f0ae7a2095474e3f3</citedby><cites>FETCH-LOGICAL-c317t-f18c4f4226976afa80c199bb44e1da126ae24a169ce419c4f0ae7a2095474e3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16772878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yilmaz, Sebnem</creatorcontrib><creatorcontrib>Duman, Nuray</creatorcontrib><creatorcontrib>Ozer, Esra</creatorcontrib><creatorcontrib>Kavas, Nazan</creatorcontrib><creatorcontrib>Oren, Hale</creatorcontrib><creatorcontrib>Demircioğlu, Fatih</creatorcontrib><creatorcontrib>Kumral, Abdullah</creatorcontrib><creatorcontrib>Ozkan, Hasan</creatorcontrib><creatorcontrib>Irken, Gülersu</creatorcontrib><creatorcontrib>Ozer, Erdener</creatorcontrib><title>A case of rhesus hemolytic disease with hemophagocytosis and severe iron overload due to multiple transfusions</title><title>Journal of pediatric hematology/oncology</title><addtitle>J Pediatr Hematol Oncol</addtitle><description>A newborn with cholestatic hepatic disease and hemophagocytic lymphohistiocytosis due to rhesus hemolytic disease (RHD) is reported.
A 34 weeks' gestation baby with RHD, who had received multiple intrauterine transfusions (IUT), developed cholestatic hepatic disease and secondary hemophagocytic lymphohistiocytosis (HLH). Her serum ferritin level increased to 5,527 ng/mL, and liver biopsy showed severe iron overload. Treatment with intravenous desferrioxamine resulted in a marked decrease in serum ferritin levels and normalization of liver function
We suggest that patients who have undergone IUT be evaluated for hyperferritinemia. If hyperferritinemia is noted, chelation therapy should be considered. As another rare finding, HLH can complicate the course of RHD.</description><subject>Adult</subject><subject>Anemia, Hemolytic, Autoimmune - complications</subject><subject>Anemia, Hemolytic, Autoimmune - therapy</subject><subject>Cholestasis, Intrahepatic - etiology</subject><subject>Cholestasis, Intrahepatic - therapy</subject><subject>Deferoxamine - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Iron Overload - etiology</subject><subject>Iron Overload - therapy</subject><subject>Lymphohistiocytosis, Hemophagocytic - etiology</subject><subject>Lymphohistiocytosis, Hemophagocytic - therapy</subject><subject>Transfusion Reaction</subject><issn>1077-4114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1LxTAMhnuh-P0XpHjh3ZlNV9fVOxG_QPBGr0tPl7nKts5mU86_t-oBAyEhed8EHsbOQBQgjL4QUAxTV4gcEqQRVSG0gLow5Q47AKH1SgGofXZI9C4E6FLJPbYPlday1vUBG6-5d4Q8tjx1SAvxDofYb-bgeRMIf3ZfYe5-x1Pn3qLfzJECcTc2nPATE_KQ4shjbvvoGt4syOfIh6Wfw9TnPrmR2oVCHOmY7bauJzzZ1iP2enf7cvOwenq-f7y5flr5EvS8aqH2qlVSVkZXrnW18GDMeq0UQuNAVg6lclAZjwpMlgqH2klhLpVWWLblETv_uzul-LEgzXYI5LHv3YhxIVvVGU3OLLz6E_oUiRK2dkphcGljQdgfwlaAzYTtP2H7S9iaMptPt1-W9YDNv3WLt_wG9Lt8sQ</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Yilmaz, Sebnem</creator><creator>Duman, Nuray</creator><creator>Ozer, Esra</creator><creator>Kavas, Nazan</creator><creator>Oren, Hale</creator><creator>Demircioğlu, Fatih</creator><creator>Kumral, Abdullah</creator><creator>Ozkan, Hasan</creator><creator>Irken, Gülersu</creator><creator>Ozer, Erdener</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>A case of rhesus hemolytic disease with hemophagocytosis and severe iron overload due to multiple transfusions</title><author>Yilmaz, Sebnem ; Duman, Nuray ; Ozer, Esra ; Kavas, Nazan ; Oren, Hale ; Demircioğlu, Fatih ; Kumral, Abdullah ; Ozkan, Hasan ; Irken, Gülersu ; Ozer, Erdener</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-f18c4f4226976afa80c199bb44e1da126ae24a169ce419c4f0ae7a2095474e3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Anemia, Hemolytic, Autoimmune - complications</topic><topic>Anemia, Hemolytic, Autoimmune - therapy</topic><topic>Cholestasis, Intrahepatic - etiology</topic><topic>Cholestasis, Intrahepatic - therapy</topic><topic>Deferoxamine - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Iron Overload - etiology</topic><topic>Iron Overload - therapy</topic><topic>Lymphohistiocytosis, Hemophagocytic - etiology</topic><topic>Lymphohistiocytosis, Hemophagocytic - therapy</topic><topic>Transfusion Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yilmaz, Sebnem</creatorcontrib><creatorcontrib>Duman, Nuray</creatorcontrib><creatorcontrib>Ozer, Esra</creatorcontrib><creatorcontrib>Kavas, Nazan</creatorcontrib><creatorcontrib>Oren, Hale</creatorcontrib><creatorcontrib>Demircioğlu, Fatih</creatorcontrib><creatorcontrib>Kumral, Abdullah</creatorcontrib><creatorcontrib>Ozkan, Hasan</creatorcontrib><creatorcontrib>Irken, Gülersu</creatorcontrib><creatorcontrib>Ozer, Erdener</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric hematology/oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yilmaz, Sebnem</au><au>Duman, Nuray</au><au>Ozer, Esra</au><au>Kavas, Nazan</au><au>Oren, Hale</au><au>Demircioğlu, Fatih</au><au>Kumral, Abdullah</au><au>Ozkan, Hasan</au><au>Irken, Gülersu</au><au>Ozer, Erdener</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of rhesus hemolytic disease with hemophagocytosis and severe iron overload due to multiple transfusions</atitle><jtitle>Journal of pediatric hematology/oncology</jtitle><addtitle>J Pediatr Hematol Oncol</addtitle><date>2006-05</date><risdate>2006</risdate><volume>28</volume><issue>5</issue><spage>290</spage><epage>292</epage><pages>290-292</pages><issn>1077-4114</issn><abstract>A newborn with cholestatic hepatic disease and hemophagocytic lymphohistiocytosis due to rhesus hemolytic disease (RHD) is reported.
A 34 weeks' gestation baby with RHD, who had received multiple intrauterine transfusions (IUT), developed cholestatic hepatic disease and secondary hemophagocytic lymphohistiocytosis (HLH). Her serum ferritin level increased to 5,527 ng/mL, and liver biopsy showed severe iron overload. Treatment with intravenous desferrioxamine resulted in a marked decrease in serum ferritin levels and normalization of liver function
We suggest that patients who have undergone IUT be evaluated for hyperferritinemia. If hyperferritinemia is noted, chelation therapy should be considered. As another rare finding, HLH can complicate the course of RHD.</abstract><cop>United States</cop><pmid>16772878</pmid><doi>10.1097/01.mph.0000212906.07018.93</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1077-4114 |
| ispartof | Journal of pediatric hematology/oncology, 2006-05, Vol.28 (5), p.290-292 |
| issn | 1077-4114 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68077807 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Anemia, Hemolytic, Autoimmune - complications Anemia, Hemolytic, Autoimmune - therapy Cholestasis, Intrahepatic - etiology Cholestasis, Intrahepatic - therapy Deferoxamine - therapeutic use Female Humans Infant, Newborn Iron Overload - etiology Iron Overload - therapy Lymphohistiocytosis, Hemophagocytic - etiology Lymphohistiocytosis, Hemophagocytic - therapy Transfusion Reaction |
| title | A case of rhesus hemolytic disease with hemophagocytosis and severe iron overload due to multiple transfusions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T16%3A47%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20case%20of%20rhesus%20hemolytic%20disease%20with%20hemophagocytosis%20and%20severe%20iron%20overload%20due%20to%20multiple%20transfusions&rft.jtitle=Journal%20of%20pediatric%20hematology/oncology&rft.au=Yilmaz,%20Sebnem&rft.date=2006-05&rft.volume=28&rft.issue=5&rft.spage=290&rft.epage=292&rft.pages=290-292&rft.issn=1077-4114&rft_id=info:doi/10.1097/01.mph.0000212906.07018.93&rft_dat=%3Cproquest_cross%3E68077807%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68077807&rft_id=info:pmid/16772878&rfr_iscdi=true |