Investigating oligonucleotide hybridization at subnanomolar level by surface plasmon resonance biosensor method

We have optimized surface plasmon resonance (SPR) biosensor technology for a rapid, direct, and low‐consumption label‐free multianalyte screening of synthetic oligonucleotides (ONs) with modified internucleotide linkages potentially applicable in antisense therapy. Monitoring of the ONs hybridizatio...

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Veröffentlicht in:	Biopolymers 2006-07, Vol.82 (4), p.394-398
Hauptverfasser:	Vaisocherová, Hana, Zítová, Alice, Lachmanová, Markéta, S̆tĕpánek, Josef, Králíková, S̆árka, Liboska, Radek, Rejman, Dominik, Rosenberg, Ivan, Homola, Jir̆í
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosensing Techniques - instrumentation Biosensing Techniques - methods hybridization Nanotechnology - instrumentation Nanotechnology - methods Nucleic Acid Hybridization - methods Oligonucleotide Array Sequence Analysis - instrumentation Oligonucleotide Array Sequence Analysis - methods oligonucleotide interactions Oligonucleotide Probes - chemistry Oligonucleotide Probes - genetics Surface Plasmon Resonance - methods surface plasmon resonance biosensor
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