Effect of in vivo administration of ethylmalonic acid on energy metabolism in rat tissues

High concentrations of ethylmalonic acid (EMA) occur in tissues and biological fluids of patients affected by deficiency of short-chain acyl-CoA dehydrogenase activity, as well as in other illnesses characterized by neurological and muscular symptoms. Considering that the pathophysiological mechanis...

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Veröffentlicht in:	Metabolic brain disease 2006-03, Vol.21 (1), p.29-39
Hauptverfasser:	FERREIRA, Gustavo Da C, ROTH ANDRE, Karina, SCHUCK, Patricia Fernanda, VIEGAS, Carolina M, TONIN, Anelise, DE MOURA COELHO, Daniella, WYSE, Angela T. S, WANNMACHER, Clovis M. D, VARGAS, Carmen R, WAJNER, Moacir
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis - metabolism Age Factors Animals Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Butyryl-CoA Dehydrogenase - deficiency Cerebral Cortex - drug effects Cerebral Cortex - enzymology Electron Transport Complex I - metabolism Electron Transport Complex II - metabolism Electron Transport Complex III - metabolism Electron Transport Complex IV - metabolism Energy Metabolism - drug effects Energy Metabolism - physiology Enzyme Activation - drug effects Enzyme Activation - physiology Female Injections, Subcutaneous Male Malonates - blood Malonates - pharmacokinetics Medical sciences Muscle, Skeletal - drug effects Muscle, Skeletal - enzymology Myocardium - enzymology Neurology Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Pregnancy Rats Rats, Wistar
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