A t(17;20)(q21;q12) masking a variant t(15;17)(q22;q21) in a patient with acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is genetically characterized by a reciprocal translocation between chromosomes 15 and 17, the t(15;17)(q22;q21), which results in the fusion gene PML/RARA. A small proportion of patients with APL have complex or simple variants of this translocation. We report the...
Gespeichert in:
| Veröffentlicht in: | Cancer genetics and cytogenetics 2006-07, Vol.168 (1), p.73-76 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 76 |
|---|---|
| container_issue | 1 |
| container_start_page | 73 |
| container_title | Cancer genetics and cytogenetics |
| container_volume | 168 |
| creator | García-Casado, Zaida Cervera, José Valencia, Ana Pajuelo, Juan C. Mena-Duran, Armando V. Barragán, Eva Bolufer, Pascual Sanz, Miguel A. |
| description | Acute promyelocytic leukemia (APL) is genetically characterized by a reciprocal translocation between chromosomes 15 and 17, the t(15;17)(q22;q21), which results in the fusion gene
PML/RARA. A small proportion of patients with APL have complex or simple variants of this translocation. We report the case of a 31-year-old woman with APL (FAB-M3 classical form) carrying an apparently balanced translocation t(17;20)(q21;q12) masking a t(15;17)(q22;q21) confirmed by fluorescence in situ hybridization (FISH) and molecular studies. The patient was treated with an all-trans-retinoic acid (ATRA) plus anthracycline-based protocol and achieved complete remission, with no recurrence to date. These results illustrate the usefulness of combining cytogenetics, FISH, and reverse transcription–polymerase chain reaction (RT-PCR) methods to evidence the
PML/RARA fusion gene in cases with morphologic suspicion of APL with variant or cryptic t(15;17). |
| doi_str_mv | 10.1016/j.cancergencyto.2005.12.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68076431</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165460806000021</els_id><sourcerecordid>20272195</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-3b52573ebfc50d99ac13ff0d18a264f54cf43ebe1243c579ae79efb7d33958ac3</originalsourceid><addsrcrecordid>eNqNkc1r3DAQxUVpaTZp_4ViKJTswa5GH5aNTyGkaSHQS3sWWnmUauOPXUlO2P--Wnah9NSe5vB-M_N4j5CPQCugUH_eVtZMFsMjTvaQ5opRKitgFQXxiqygUbwUQtavySrTshQ1bS7IZYxbSqlibf2WXECtFAMmVsTdFOkaVMfo-nrPoNsDWxejiU9-eixM8WyCN1M6MrIDdWRYl7l14acs70zymOUXn34Vxi4Ji12YxwMOc7bmbTHg8oSjN-_IG2eGiO_P84r8_HL34_Zr-fD9_tvtzUNpBbBU8o1kUnHcOCtp37bGAneO9tAYVgsnhXUiq5itcytVa1C16Daq57yVjbH8inw63c029gvGpEcfLQ6DmXBeoq4bqmrB4Z8goywn1MoMdifQhjnGgE7vgh9NOGig-tiH3uq_-tDHPjQwnfvI2x_Ob5bNiP2f3XMBGbg7AZhTefYYdLQ5Uou9D2iT7mf_X49-A1YXoF8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20272195</pqid></control><display><type>article</type><title>A t(17;20)(q21;q12) masking a variant t(15;17)(q22;q21) in a patient with acute promyelocytic leukemia</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>García-Casado, Zaida ; Cervera, José ; Valencia, Ana ; Pajuelo, Juan C. ; Mena-Duran, Armando V. ; Barragán, Eva ; Bolufer, Pascual ; Sanz, Miguel A.</creator><creatorcontrib>García-Casado, Zaida ; Cervera, José ; Valencia, Ana ; Pajuelo, Juan C. ; Mena-Duran, Armando V. ; Barragán, Eva ; Bolufer, Pascual ; Sanz, Miguel A.</creatorcontrib><description>Acute promyelocytic leukemia (APL) is genetically characterized by a reciprocal translocation between chromosomes 15 and 17, the t(15;17)(q22;q21), which results in the fusion gene
PML/RARA. A small proportion of patients with APL have complex or simple variants of this translocation. We report the case of a 31-year-old woman with APL (FAB-M3 classical form) carrying an apparently balanced translocation t(17;20)(q21;q12) masking a t(15;17)(q22;q21) confirmed by fluorescence in situ hybridization (FISH) and molecular studies. The patient was treated with an all-trans-retinoic acid (ATRA) plus anthracycline-based protocol and achieved complete remission, with no recurrence to date. These results illustrate the usefulness of combining cytogenetics, FISH, and reverse transcription–polymerase chain reaction (RT-PCR) methods to evidence the
PML/RARA fusion gene in cases with morphologic suspicion of APL with variant or cryptic t(15;17).</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/j.cancergencyto.2005.12.014</identifier><identifier>PMID: 16772124</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Anthracyclines - therapeutic use ; Chromosome Painting ; Chromosomes, Human, Pair 15 - genetics ; Chromosomes, Human, Pair 17 - genetics ; Chromosomes, Human, Pair 20 - genetics ; Female ; Humans ; In Situ Hybridization, Fluorescence ; Leukemia, Promyelocytic, Acute - drug therapy ; Leukemia, Promyelocytic, Acute - genetics ; Neoplasm Proteins - genetics ; Oncogene Proteins, Fusion - genetics ; Remission Induction ; Reverse Transcriptase Polymerase Chain Reaction ; Translocation, Genetic - genetics ; Tretinoin - therapeutic use</subject><ispartof>Cancer genetics and cytogenetics, 2006-07, Vol.168 (1), p.73-76</ispartof><rights>2006 Elsevier Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-3b52573ebfc50d99ac13ff0d18a264f54cf43ebe1243c579ae79efb7d33958ac3</citedby><cites>FETCH-LOGICAL-c412t-3b52573ebfc50d99ac13ff0d18a264f54cf43ebe1243c579ae79efb7d33958ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165460806000021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16772124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García-Casado, Zaida</creatorcontrib><creatorcontrib>Cervera, José</creatorcontrib><creatorcontrib>Valencia, Ana</creatorcontrib><creatorcontrib>Pajuelo, Juan C.</creatorcontrib><creatorcontrib>Mena-Duran, Armando V.</creatorcontrib><creatorcontrib>Barragán, Eva</creatorcontrib><creatorcontrib>Bolufer, Pascual</creatorcontrib><creatorcontrib>Sanz, Miguel A.</creatorcontrib><title>A t(17;20)(q21;q12) masking a variant t(15;17)(q22;q21) in a patient with acute promyelocytic leukemia</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>Acute promyelocytic leukemia (APL) is genetically characterized by a reciprocal translocation between chromosomes 15 and 17, the t(15;17)(q22;q21), which results in the fusion gene
PML/RARA. A small proportion of patients with APL have complex or simple variants of this translocation. We report the case of a 31-year-old woman with APL (FAB-M3 classical form) carrying an apparently balanced translocation t(17;20)(q21;q12) masking a t(15;17)(q22;q21) confirmed by fluorescence in situ hybridization (FISH) and molecular studies. The patient was treated with an all-trans-retinoic acid (ATRA) plus anthracycline-based protocol and achieved complete remission, with no recurrence to date. These results illustrate the usefulness of combining cytogenetics, FISH, and reverse transcription–polymerase chain reaction (RT-PCR) methods to evidence the
PML/RARA fusion gene in cases with morphologic suspicion of APL with variant or cryptic t(15;17).</description><subject>Adult</subject><subject>Anthracyclines - therapeutic use</subject><subject>Chromosome Painting</subject><subject>Chromosomes, Human, Pair 15 - genetics</subject><subject>Chromosomes, Human, Pair 17 - genetics</subject><subject>Chromosomes, Human, Pair 20 - genetics</subject><subject>Female</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Leukemia, Promyelocytic, Acute - drug therapy</subject><subject>Leukemia, Promyelocytic, Acute - genetics</subject><subject>Neoplasm Proteins - genetics</subject><subject>Oncogene Proteins, Fusion - genetics</subject><subject>Remission Induction</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Translocation, Genetic - genetics</subject><subject>Tretinoin - therapeutic use</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1r3DAQxUVpaTZp_4ViKJTswa5GH5aNTyGkaSHQS3sWWnmUauOPXUlO2P--Wnah9NSe5vB-M_N4j5CPQCugUH_eVtZMFsMjTvaQ5opRKitgFQXxiqygUbwUQtavySrTshQ1bS7IZYxbSqlibf2WXECtFAMmVsTdFOkaVMfo-nrPoNsDWxejiU9-eixM8WyCN1M6MrIDdWRYl7l14acs70zymOUXn34Vxi4Ji12YxwMOc7bmbTHg8oSjN-_IG2eGiO_P84r8_HL34_Zr-fD9_tvtzUNpBbBU8o1kUnHcOCtp37bGAneO9tAYVgsnhXUiq5itcytVa1C16Daq57yVjbH8inw63c029gvGpEcfLQ6DmXBeoq4bqmrB4Z8goywn1MoMdifQhjnGgE7vgh9NOGig-tiH3uq_-tDHPjQwnfvI2x_Ob5bNiP2f3XMBGbg7AZhTefYYdLQ5Uou9D2iT7mf_X49-A1YXoF8</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>García-Casado, Zaida</creator><creator>Cervera, José</creator><creator>Valencia, Ana</creator><creator>Pajuelo, Juan C.</creator><creator>Mena-Duran, Armando V.</creator><creator>Barragán, Eva</creator><creator>Bolufer, Pascual</creator><creator>Sanz, Miguel A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060701</creationdate><title>A t(17;20)(q21;q12) masking a variant t(15;17)(q22;q21) in a patient with acute promyelocytic leukemia</title><author>García-Casado, Zaida ; Cervera, José ; Valencia, Ana ; Pajuelo, Juan C. ; Mena-Duran, Armando V. ; Barragán, Eva ; Bolufer, Pascual ; Sanz, Miguel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-3b52573ebfc50d99ac13ff0d18a264f54cf43ebe1243c579ae79efb7d33958ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Anthracyclines - therapeutic use</topic><topic>Chromosome Painting</topic><topic>Chromosomes, Human, Pair 15 - genetics</topic><topic>Chromosomes, Human, Pair 17 - genetics</topic><topic>Chromosomes, Human, Pair 20 - genetics</topic><topic>Female</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Leukemia, Promyelocytic, Acute - drug therapy</topic><topic>Leukemia, Promyelocytic, Acute - genetics</topic><topic>Neoplasm Proteins - genetics</topic><topic>Oncogene Proteins, Fusion - genetics</topic><topic>Remission Induction</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Translocation, Genetic - genetics</topic><topic>Tretinoin - therapeutic use</topic><toplevel>online_resources</toplevel><creatorcontrib>García-Casado, Zaida</creatorcontrib><creatorcontrib>Cervera, José</creatorcontrib><creatorcontrib>Valencia, Ana</creatorcontrib><creatorcontrib>Pajuelo, Juan C.</creatorcontrib><creatorcontrib>Mena-Duran, Armando V.</creatorcontrib><creatorcontrib>Barragán, Eva</creatorcontrib><creatorcontrib>Bolufer, Pascual</creatorcontrib><creatorcontrib>Sanz, Miguel A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García-Casado, Zaida</au><au>Cervera, José</au><au>Valencia, Ana</au><au>Pajuelo, Juan C.</au><au>Mena-Duran, Armando V.</au><au>Barragán, Eva</au><au>Bolufer, Pascual</au><au>Sanz, Miguel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A t(17;20)(q21;q12) masking a variant t(15;17)(q22;q21) in a patient with acute promyelocytic leukemia</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>168</volume><issue>1</issue><spage>73</spage><epage>76</epage><pages>73-76</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><abstract>Acute promyelocytic leukemia (APL) is genetically characterized by a reciprocal translocation between chromosomes 15 and 17, the t(15;17)(q22;q21), which results in the fusion gene
PML/RARA. A small proportion of patients with APL have complex or simple variants of this translocation. We report the case of a 31-year-old woman with APL (FAB-M3 classical form) carrying an apparently balanced translocation t(17;20)(q21;q12) masking a t(15;17)(q22;q21) confirmed by fluorescence in situ hybridization (FISH) and molecular studies. The patient was treated with an all-trans-retinoic acid (ATRA) plus anthracycline-based protocol and achieved complete remission, with no recurrence to date. These results illustrate the usefulness of combining cytogenetics, FISH, and reverse transcription–polymerase chain reaction (RT-PCR) methods to evidence the
PML/RARA fusion gene in cases with morphologic suspicion of APL with variant or cryptic t(15;17).</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16772124</pmid><doi>10.1016/j.cancergencyto.2005.12.014</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-4608 |
| ispartof | Cancer genetics and cytogenetics, 2006-07, Vol.168 (1), p.73-76 |
| issn | 0165-4608 1873-4456 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68076431 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Anthracyclines - therapeutic use Chromosome Painting Chromosomes, Human, Pair 15 - genetics Chromosomes, Human, Pair 17 - genetics Chromosomes, Human, Pair 20 - genetics Female Humans In Situ Hybridization, Fluorescence Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Neoplasm Proteins - genetics Oncogene Proteins, Fusion - genetics Remission Induction Reverse Transcriptase Polymerase Chain Reaction Translocation, Genetic - genetics Tretinoin - therapeutic use |
| title | A t(17;20)(q21;q12) masking a variant t(15;17)(q22;q21) in a patient with acute promyelocytic leukemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T16%3A14%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20t(17;20)(q21;q12)%20masking%20a%20variant%20t(15;17)(q22;q21)%20in%20a%20patient%20with%20acute%20promyelocytic%20leukemia&rft.jtitle=Cancer%20genetics%20and%20cytogenetics&rft.au=Garc%C3%ADa-Casado,%20Zaida&rft.date=2006-07-01&rft.volume=168&rft.issue=1&rft.spage=73&rft.epage=76&rft.pages=73-76&rft.issn=0165-4608&rft.eissn=1873-4456&rft_id=info:doi/10.1016/j.cancergencyto.2005.12.014&rft_dat=%3Cproquest_cross%3E20272195%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20272195&rft_id=info:pmid/16772124&rft_els_id=S0165460806000021&rfr_iscdi=true |