Genomic and evolutionary insights into genes encoding proteins with single amino acid repeats

Mutations causing expansion of amino acid repeats are responsible for 19 hereditary disorders. Repeats in several other proteins also show length variations. These observations prompted us to identify single amino acid repeat-containing proteins (SARPs) in humans and to understand their functional a...

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Veröffentlicht in:	Molecular biology and evolution 2006-07, Vol.23 (7), p.1357-1369
Hauptverfasser:	Siwach, Pratibha, Pophaly, Saurabh Dilip, Ganesh, Subramaniam
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Codon - genetics Computational Biology - methods Evolution, Molecular Female GC Rich Sequence - genetics Gene Frequency Genome, Human - genetics Genomics Humans Male Polymorphism, Genetic - genetics Proteins - genetics Repetitive Sequences, Amino Acid - genetics Trinucleotide Repeat Expansion - genetics Trinucleotide Repeats - genetics
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