Cinnamophilin reduces oxidative damage and protects against transient focal cerebral ischemia in mice

Acute neuroprotective effects of cinnamophilin (CINN; (8R, 8'S)-4, 4'-dihydroxy-3, 3'-dimethoxy-7-oxo-8, 8'-neolignan), a novel antioxidant and free radical scavenger, were studied in a mouse model of transient middle cerebral artery (MCA) occlusion. CINN was administered intrape...

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Veröffentlicht in:	Free radical biology & medicine 2005-08, Vol.39 (4), p.495-510
Hauptverfasser:	Lee, E-Jian, Chen, Hung-Yi, Lee, Ming-Yang, Chen, Tsung-Ying, Hsu, Yun-Shang, Hu, Yu-Ling, Chang, Guan-Liang, Wu, Tian-Shung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - therapeutic use Brain Ischemia - drug therapy Brain Ischemia - prevention & control Cerebral Cortex - blood supply Cerebrovascular Circulation - drug effects Free Radical Scavengers - therapeutic use Guaiacol - analogs & derivatives Guaiacol - therapeutic use Infarction, Middle Cerebral Artery - physiopathology Lignans - therapeutic use Male Mice Mice, Inbred C57BL Oxidative Stress - drug effects Rats Rats, Sprague-Dawley Reactive Oxygen Species - antagonists & inhibitors Reperfusion Injury - prevention & control Time Factors
Online-Zugang:	Volltext
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