Release of Bradykinin and Expression of Kinin B2 Receptors in the Brain: Role for Cell Death and Brain Edema Formation After Focal Cerebral Ischemia in Mice

Pharmacological studies using bradykinin B2 receptor antagonists suggest that bradykinin, an early mediator of inflammation and the main metabolite of the kallikrein-kinin system, is involved in secondary brain damage after cerebral ischemia. However, the time-course of bradykinin production and kin...

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Veröffentlicht in:	Journal of Cerebral Blood Flow & Metabolism 2005-08, Vol.25 (8), p.978-989
Hauptverfasser:	Gröger, Moritz, Lebesgue, Diane, Pruneau, Didier, Relton, Jane, Kim, Seong-Woong, Nussberger, Jürg, Plesnila, Nikolaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Bradykinin - blood Bradykinin - metabolism Brain Chemistry - physiology Brain Edema - pathology Brain Ischemia - pathology Cell Death - physiology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebral Infarction - pathology Fundamental and applied biological sciences. Psychology Immunohistochemistry Kinetics Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Motor Activity - physiology Neurology Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Receptor, Bradykinin B2 - biosynthesis Receptor, Bradykinin B2 - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis Survival Analysis Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs
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