Folate receptor‐targeted immunotherapy: Induction of humoral and cellular immunity against hapten‐decorated cancer cells

We previously exploited the frequent overexpression of folate receptors on cancer cells to decorate malignant cell surfaces selectively with folate‐hapten conjugates. In antihapten‐immunized hosts, this targeted localization of foreign haptens to tumor cells led to rapid accumulation of autologous a...

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Veröffentlicht in:	International journal of cancer 2005-09, Vol.116 (5), p.710-719
Hauptverfasser:	Lu, Yingjuan, Sega, Emanuela, Low, Philip S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody-Dependent Cell Cytotoxicity Antineoplastic agents Biological and medical sciences Carrier Proteins - immunology cytokine immunostimulation Fc‐expressing immune cells Female Fluorescein-5-isothiocyanate folate receptor Folate Receptors, GPI-Anchored Folic Acid - immunology Haptens - immunology Immunoglobulin G - blood Immunologic Memory Immunotherapy Killer Cells, Natural - immunology Macrophages - immunology Medical sciences Mice Mice, Inbred BALB C Neoplasms, Experimental - immunology Neoplasms, Experimental - therapy Phagocytosis Pharmacology. Drug treatments Receptors, Cell Surface - immunology T-Lymphocytes - immunology targeting of folate‐hapten conjugates tumor immunotherapy Tumors
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