The G894T polymorphism on endothelial nitric oxide synthase gene is associated with premature coronary artery disease in a Turkish population
The aim of the present study was to investigate the association between premature coronary artery disease and Glu298Asp polymorphism of the endothelial nitric oxide synthase gene. The eNOS gene polymorphism was analysed in 115 (mean age, 48.1±7.9 years) Turkish patients with a diagnosis of premature...
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| Veröffentlicht in: | Thrombosis research 2005, Vol.116 (4), p.287-292 |
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| creator | Cam, Sirri F. Sekuri, Cevad Tengiz, Istemihan Ercan, Ertugrul Sagcan, Abdi Akin, Mustafa Berdeli, Afig |
| description | The aim of the present study was to investigate the association between premature coronary artery disease and Glu298Asp polymorphism of the endothelial nitric oxide synthase gene.
The eNOS gene polymorphism was analysed in 115 (mean age, 48.1±7.9 years) Turkish patients with a diagnosis of premature coronary artery disease and 83 (mean age, 44.6±1.4 years) control subjects. The Glu298Asp polymorphism of the endothelial nitric oxide synthase gene was determined by polymerase chain reaction and restriction fragment length polymorphism.
The patients group showed an increase in the frequency of the T allele compared to controls (0.456 versus 0.169,
p=0.0001). There was a significant association between the TT genotype and premature coronary artery disease [eNOS TT vs. TG and GG; OR=17.000 (CI 95% 3.952–73.125,
p=0.0001)]. The eNOS T/G genotypes were not associated with the number of affected vessels (
p>0.05). In addition, the family history of premature coronary artery disease, smoking, diabetes, obesity, dyslipidemia and eNOS TT genotype were independent risk factors of coronary artery disease. The patients with eNOS TT genotype had 15 fold risk of coronary artery disease compared with the control group [OR=15.356(CI 95% 3.262–77.289,
p=0.001)].
These results suggest that premature coronary artery disease is associated with the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in our population. |
| doi_str_mv | 10.1016/j.thromres.2004.12.002 |
| format | Article |
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The eNOS gene polymorphism was analysed in 115 (mean age, 48.1±7.9 years) Turkish patients with a diagnosis of premature coronary artery disease and 83 (mean age, 44.6±1.4 years) control subjects. The Glu298Asp polymorphism of the endothelial nitric oxide synthase gene was determined by polymerase chain reaction and restriction fragment length polymorphism.
The patients group showed an increase in the frequency of the T allele compared to controls (0.456 versus 0.169,
p=0.0001). There was a significant association between the TT genotype and premature coronary artery disease [eNOS TT vs. TG and GG; OR=17.000 (CI 95% 3.952–73.125,
p=0.0001)]. The eNOS T/G genotypes were not associated with the number of affected vessels (
p>0.05). In addition, the family history of premature coronary artery disease, smoking, diabetes, obesity, dyslipidemia and eNOS TT genotype were independent risk factors of coronary artery disease. The patients with eNOS TT genotype had 15 fold risk of coronary artery disease compared with the control group [OR=15.356(CI 95% 3.262–77.289,
p=0.001)].
These results suggest that premature coronary artery disease is associated with the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in our population.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/j.thromres.2004.12.002</identifier><identifier>PMID: 16038712</identifier><identifier>CODEN: THBRAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Ltd</publisher><subject>Adult ; Age of Onset ; Amino Acid Substitution ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Case-Control Studies ; Coronary Artery Disease - enzymology ; Coronary Artery Disease - genetics ; Coronary heart disease ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; DNA Mutational Analysis ; Endothelial nitric oxide synthase ; Gene Frequency ; Gene polymorphism ; Genotype ; Heart ; Humans ; Medical sciences ; Middle Aged ; Nitric Oxide Synthase - genetics ; Nitric Oxide Synthase Type III ; Polymorphism, Single Nucleotide ; Premature coronary artery disease ; Risk Factors ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Turkey - epidemiology</subject><ispartof>Thrombosis research, 2005, Vol.116 (4), p.287-292</ispartof><rights>2004 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-6cfb768267b9f1f310553bb0fdb5251430fbf194d9ea9ec4432e8cd0a5d8100c3</citedby><cites>FETCH-LOGICAL-c396t-6cfb768267b9f1f310553bb0fdb5251430fbf194d9ea9ec4432e8cd0a5d8100c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0049384804006322$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16992715$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16038712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cam, Sirri F.</creatorcontrib><creatorcontrib>Sekuri, Cevad</creatorcontrib><creatorcontrib>Tengiz, Istemihan</creatorcontrib><creatorcontrib>Ercan, Ertugrul</creatorcontrib><creatorcontrib>Sagcan, Abdi</creatorcontrib><creatorcontrib>Akin, Mustafa</creatorcontrib><creatorcontrib>Berdeli, Afig</creatorcontrib><title>The G894T polymorphism on endothelial nitric oxide synthase gene is associated with premature coronary artery disease in a Turkish population</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>The aim of the present study was to investigate the association between premature coronary artery disease and Glu298Asp polymorphism of the endothelial nitric oxide synthase gene.
The eNOS gene polymorphism was analysed in 115 (mean age, 48.1±7.9 years) Turkish patients with a diagnosis of premature coronary artery disease and 83 (mean age, 44.6±1.4 years) control subjects. The Glu298Asp polymorphism of the endothelial nitric oxide synthase gene was determined by polymerase chain reaction and restriction fragment length polymorphism.
The patients group showed an increase in the frequency of the T allele compared to controls (0.456 versus 0.169,
p=0.0001). There was a significant association between the TT genotype and premature coronary artery disease [eNOS TT vs. TG and GG; OR=17.000 (CI 95% 3.952–73.125,
p=0.0001)]. The eNOS T/G genotypes were not associated with the number of affected vessels (
p>0.05). In addition, the family history of premature coronary artery disease, smoking, diabetes, obesity, dyslipidemia and eNOS TT genotype were independent risk factors of coronary artery disease. The patients with eNOS TT genotype had 15 fold risk of coronary artery disease compared with the control group [OR=15.356(CI 95% 3.262–77.289,
p=0.001)].
These results suggest that premature coronary artery disease is associated with the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in our population.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Amino Acid Substitution</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Coronary Artery Disease - enzymology</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary heart disease</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>DNA Mutational Analysis</subject><subject>Endothelial nitric oxide synthase</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genotype</subject><subject>Heart</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitric Oxide Synthase Type III</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Premature coronary artery disease</subject><subject>Risk Factors</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Turkey - epidemiology</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuO1DAQRS0EYnoGfmHkDewSbOfpHWgEA9JIbJq15dgV4iaxg8uB6Y_gn3GrG8GOVS3q3HrcS8gtZyVnvH1zKNMUwxIBS8FYXXJRMiaekB3vO1mIuhNPyS43ZFH1dX9FrhEPjPGOy-Y5ueItq_qOix35tZ-A3vey3tM1zMclxHVyuNDgKXgb0gSz0zP1LkVnaHh0FigefZo0Av0KHqhDqhGDcTqBpT9dmugaYdFpi0BNiMHreKQ6JsjFOoST0nmq6X6L3xxmPKzbrJML_gV5NuoZ4eWl3pAvH97v7z4WD5_vP929eyhMJdtUtGYcurYXbTfIkY8VZ01TDQMb7dCIhtcVG4eRy9pK0BJMXVcCemOZbmzPGTPVDXl9nrvG8H0DTGpxaGCetYewoWp71gnOugy2Z9DEgBhhVGt0S35IcaZOQaiD-hOEOgWhuFA5iCy8vWzYhgXsX9nF-Qy8ugAajZ7HqL1x-A8npeh4k7m3Zw6yHz8cRIXGgTdgXQSTlA3uf7f8BpaOrac</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Cam, Sirri F.</creator><creator>Sekuri, Cevad</creator><creator>Tengiz, Istemihan</creator><creator>Ercan, Ertugrul</creator><creator>Sagcan, Abdi</creator><creator>Akin, Mustafa</creator><creator>Berdeli, Afig</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>The G894T polymorphism on endothelial nitric oxide synthase gene is associated with premature coronary artery disease in a Turkish population</title><author>Cam, Sirri F. ; Sekuri, Cevad ; Tengiz, Istemihan ; Ercan, Ertugrul ; Sagcan, Abdi ; Akin, Mustafa ; Berdeli, Afig</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-6cfb768267b9f1f310553bb0fdb5251430fbf194d9ea9ec4432e8cd0a5d8100c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Amino Acid Substitution</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Coronary Artery Disease - enzymology</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary heart disease</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>DNA Mutational Analysis</topic><topic>Endothelial nitric oxide synthase</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genotype</topic><topic>Heart</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nitric Oxide Synthase - genetics</topic><topic>Nitric Oxide Synthase Type III</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Premature coronary artery disease</topic><topic>Risk Factors</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Turkey - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cam, Sirri F.</creatorcontrib><creatorcontrib>Sekuri, Cevad</creatorcontrib><creatorcontrib>Tengiz, Istemihan</creatorcontrib><creatorcontrib>Ercan, Ertugrul</creatorcontrib><creatorcontrib>Sagcan, Abdi</creatorcontrib><creatorcontrib>Akin, Mustafa</creatorcontrib><creatorcontrib>Berdeli, Afig</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cam, Sirri F.</au><au>Sekuri, Cevad</au><au>Tengiz, Istemihan</au><au>Ercan, Ertugrul</au><au>Sagcan, Abdi</au><au>Akin, Mustafa</au><au>Berdeli, Afig</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The G894T polymorphism on endothelial nitric oxide synthase gene is associated with premature coronary artery disease in a Turkish population</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2005</date><risdate>2005</risdate><volume>116</volume><issue>4</issue><spage>287</spage><epage>292</epage><pages>287-292</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>The aim of the present study was to investigate the association between premature coronary artery disease and Glu298Asp polymorphism of the endothelial nitric oxide synthase gene.
The eNOS gene polymorphism was analysed in 115 (mean age, 48.1±7.9 years) Turkish patients with a diagnosis of premature coronary artery disease and 83 (mean age, 44.6±1.4 years) control subjects. The Glu298Asp polymorphism of the endothelial nitric oxide synthase gene was determined by polymerase chain reaction and restriction fragment length polymorphism.
The patients group showed an increase in the frequency of the T allele compared to controls (0.456 versus 0.169,
p=0.0001). There was a significant association between the TT genotype and premature coronary artery disease [eNOS TT vs. TG and GG; OR=17.000 (CI 95% 3.952–73.125,
p=0.0001)]. The eNOS T/G genotypes were not associated with the number of affected vessels (
p>0.05). In addition, the family history of premature coronary artery disease, smoking, diabetes, obesity, dyslipidemia and eNOS TT genotype were independent risk factors of coronary artery disease. The patients with eNOS TT genotype had 15 fold risk of coronary artery disease compared with the control group [OR=15.356(CI 95% 3.262–77.289,
p=0.001)].
These results suggest that premature coronary artery disease is associated with the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in our population.</abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>16038712</pmid><doi>10.1016/j.thromres.2004.12.002</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Thrombosis research, 2005, Vol.116 (4), p.287-292 |
| issn | 0049-3848 1879-2472 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Age of Onset Amino Acid Substitution Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Case-Control Studies Coronary Artery Disease - enzymology Coronary Artery Disease - genetics Coronary heart disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous DNA Mutational Analysis Endothelial nitric oxide synthase Gene Frequency Gene polymorphism Genotype Heart Humans Medical sciences Middle Aged Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type III Polymorphism, Single Nucleotide Premature coronary artery disease Risk Factors Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Turkey - epidemiology |
| title | The G894T polymorphism on endothelial nitric oxide synthase gene is associated with premature coronary artery disease in a Turkish population |
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