Scale for the assessment and rating of ataxia : Development of a new clinical scale
To develop a reliable and valid clinical scale measuring the severity of ataxia. The authors devised the Scale for the Assessment and Rating of Ataxia (SARA) and tested it in two trials of 167 and 119 patients with spinocerebellar ataxia. The mean time to administer SARA in patients was 14.2 +/- 7.5...
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| Veröffentlicht in: | Neurology 2006-06, Vol.66 (11), p.1717-1720 |
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| creator | SCHMITZ-HÜBSCH, T TEZENAS DU MONTCEL, S KREMER, B MARIOTTI, C MELEGH, B PANDOLFO, M RAKOWICZ, M RIBAI, P ROLA, R SCHOLS, L SZYMANSKI, S VAN DE WARRENBURG, B. P BALIKO, L DÜRR, A KLOCKGETHER, T BERCIANO, J BOESCH, S DEPONDT, C GIUNTI, P GLOBAS, C INFANTE, J KANG, J.-S |
| description | To develop a reliable and valid clinical scale measuring the severity of ataxia.
The authors devised the Scale for the Assessment and Rating of Ataxia (SARA) and tested it in two trials of 167 and 119 patients with spinocerebellar ataxia.
The mean time to administer SARA in patients was 14.2 +/- 7.5 minutes (range 5 to 40). Interrater reliability was high, with an intraclass coefficient (ICC) of 0.98. Test-retest reliability was high with an ICC of 0.90. Internal consistency was high as indicated by Cronbach's alpha of 0.94. Factorial analysis revealed that the rating results were determined by a single factor. SARA ratings showed a linear relation to global assessments using a visual analogue scale, suggesting linearity of the scale (p < 0.0001, r(2) = 0.98). SARA score increased with the disease stage (p < 0.001) and was closely correlated with the Barthel Index (r = -0.80, p < 0.001) and part IV (functional assessment) of the Unified Huntington's Disease Rating Scale (UHDRS-IV) (r = -0.89, p < 0.0001), whereas it had only a weak correlation with disease duration (r = 0.34, p < 0.0002).
The Scale for the Assessment and Rating of Ataxia is a reliable and valid measure of ataxia, making it an appropriate primary outcome measure for clinical trials. |
| doi_str_mv | 10.1212/01.wnl.0000219042.60538.92 |
| format | Article |
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The authors devised the Scale for the Assessment and Rating of Ataxia (SARA) and tested it in two trials of 167 and 119 patients with spinocerebellar ataxia.
The mean time to administer SARA in patients was 14.2 +/- 7.5 minutes (range 5 to 40). Interrater reliability was high, with an intraclass coefficient (ICC) of 0.98. Test-retest reliability was high with an ICC of 0.90. Internal consistency was high as indicated by Cronbach's alpha of 0.94. Factorial analysis revealed that the rating results were determined by a single factor. SARA ratings showed a linear relation to global assessments using a visual analogue scale, suggesting linearity of the scale (p < 0.0001, r(2) = 0.98). SARA score increased with the disease stage (p < 0.001) and was closely correlated with the Barthel Index (r = -0.80, p < 0.001) and part IV (functional assessment) of the Unified Huntington's Disease Rating Scale (UHDRS-IV) (r = -0.89, p < 0.0001), whereas it had only a weak correlation with disease duration (r = 0.34, p < 0.0002).
The Scale for the Assessment and Rating of Ataxia is a reliable and valid measure of ataxia, making it an appropriate primary outcome measure for clinical trials.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/01.wnl.0000219042.60538.92</identifier><identifier>PMID: 16769946</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Development. Senescence. Regeneration. Transplantation ; Female ; Fundamental and applied biological sciences. Psychology ; Health Status Indicators ; Humans ; Male ; Medical sciences ; Middle Aged ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurologic Examination - methods ; Neurology ; Outcome Assessment (Health Care) - methods ; Reproducibility of Results ; Sensitivity and Specificity ; Severity of Illness Index ; Spinocerebellar Ataxias - classification ; Spinocerebellar Ataxias - diagnosis ; Vertebrates: nervous system and sense organs</subject><ispartof>Neurology, 2006-06, Vol.66 (11), p.1717-1720</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-931a16e13b46df0f67e3307afebe75fbc53b88aa56b9db964998a0c4c7daf14a3</citedby><cites>FETCH-LOGICAL-c347t-931a16e13b46df0f67e3307afebe75fbc53b88aa56b9db964998a0c4c7daf14a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17859949$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16769946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHMITZ-HÜBSCH, T</creatorcontrib><creatorcontrib>TEZENAS DU MONTCEL, S</creatorcontrib><creatorcontrib>KREMER, B</creatorcontrib><creatorcontrib>MARIOTTI, C</creatorcontrib><creatorcontrib>MELEGH, B</creatorcontrib><creatorcontrib>PANDOLFO, M</creatorcontrib><creatorcontrib>RAKOWICZ, M</creatorcontrib><creatorcontrib>RIBAI, P</creatorcontrib><creatorcontrib>ROLA, R</creatorcontrib><creatorcontrib>SCHOLS, L</creatorcontrib><creatorcontrib>SZYMANSKI, S</creatorcontrib><creatorcontrib>VAN DE WARRENBURG, B. P</creatorcontrib><creatorcontrib>BALIKO, L</creatorcontrib><creatorcontrib>DÜRR, A</creatorcontrib><creatorcontrib>KLOCKGETHER, T</creatorcontrib><creatorcontrib>BERCIANO, J</creatorcontrib><creatorcontrib>BOESCH, S</creatorcontrib><creatorcontrib>DEPONDT, C</creatorcontrib><creatorcontrib>GIUNTI, P</creatorcontrib><creatorcontrib>GLOBAS, C</creatorcontrib><creatorcontrib>INFANTE, J</creatorcontrib><creatorcontrib>KANG, J.-S</creatorcontrib><title>Scale for the assessment and rating of ataxia : Development of a new clinical scale</title><title>Neurology</title><addtitle>Neurology</addtitle><description>To develop a reliable and valid clinical scale measuring the severity of ataxia.
The authors devised the Scale for the Assessment and Rating of Ataxia (SARA) and tested it in two trials of 167 and 119 patients with spinocerebellar ataxia.
The mean time to administer SARA in patients was 14.2 +/- 7.5 minutes (range 5 to 40). Interrater reliability was high, with an intraclass coefficient (ICC) of 0.98. Test-retest reliability was high with an ICC of 0.90. Internal consistency was high as indicated by Cronbach's alpha of 0.94. Factorial analysis revealed that the rating results were determined by a single factor. SARA ratings showed a linear relation to global assessments using a visual analogue scale, suggesting linearity of the scale (p < 0.0001, r(2) = 0.98). SARA score increased with the disease stage (p < 0.001) and was closely correlated with the Barthel Index (r = -0.80, p < 0.001) and part IV (functional assessment) of the Unified Huntington's Disease Rating Scale (UHDRS-IV) (r = -0.89, p < 0.0001), whereas it had only a weak correlation with disease duration (r = 0.34, p < 0.0002).
The Scale for the Assessment and Rating of Ataxia is a reliable and valid measure of ataxia, making it an appropriate primary outcome measure for clinical trials.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health Status Indicators</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurologic Examination - methods</subject><subject>Neurology</subject><subject>Outcome Assessment (Health Care) - methods</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Spinocerebellar Ataxias - classification</subject><subject>Spinocerebellar Ataxias - diagnosis</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkNtKxDAQhoMo7np4BQmC3rUmTZuDd7IeQfBCBe_CNJ1opduuTdfVtzddFzY3A5lv_mE-Qk45S3nGswvG01XbpCy-jBuWZ6lkhdCpyXbIlBeZTKTI3nbJNPZ1IrTSE3IQwidjsanMPplwqaQxuZyS52cHDVLf9XT4QAohYAhzbAcKbUV7GOr2nXaewgA_NdBLeo3f2HSLNTL-0xZX1DV1W8cgGsa0I7LnoQl4vKmH5PX25mV2nzw-3T3Mrh4TJ3I1JEZw4BK5KHNZeealQiGYAo8lqsKXrhCl1gCFLE1VGpkbo4G53KkKPM9BHJLz_9xF330tMQx2XgeHTQMtdstgpWaKC5lH8PIfdH0XQo_eLvp6Dv2v5cyOSi3jNiq1W6V2rdSaLA6fbLYsyzlW29GNwwicbQAYz_c9tK4OW07pInJG_AENKoBU</recordid><startdate>20060613</startdate><enddate>20060613</enddate><creator>SCHMITZ-HÜBSCH, T</creator><creator>TEZENAS DU MONTCEL, S</creator><creator>KREMER, B</creator><creator>MARIOTTI, C</creator><creator>MELEGH, B</creator><creator>PANDOLFO, M</creator><creator>RAKOWICZ, M</creator><creator>RIBAI, P</creator><creator>ROLA, R</creator><creator>SCHOLS, L</creator><creator>SZYMANSKI, S</creator><creator>VAN DE WARRENBURG, B. 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P ; BALIKO, L ; DÜRR, A ; KLOCKGETHER, T ; BERCIANO, J ; BOESCH, S ; DEPONDT, C ; GIUNTI, P ; GLOBAS, C ; INFANTE, J ; KANG, J.-S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-931a16e13b46df0f67e3307afebe75fbc53b88aa56b9db964998a0c4c7daf14a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health Status Indicators</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurologic Examination - methods</topic><topic>Neurology</topic><topic>Outcome Assessment (Health Care) - methods</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Spinocerebellar Ataxias - classification</topic><topic>Spinocerebellar Ataxias - diagnosis</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHMITZ-HÜBSCH, T</creatorcontrib><creatorcontrib>TEZENAS DU MONTCEL, S</creatorcontrib><creatorcontrib>KREMER, B</creatorcontrib><creatorcontrib>MARIOTTI, C</creatorcontrib><creatorcontrib>MELEGH, B</creatorcontrib><creatorcontrib>PANDOLFO, M</creatorcontrib><creatorcontrib>RAKOWICZ, M</creatorcontrib><creatorcontrib>RIBAI, P</creatorcontrib><creatorcontrib>ROLA, R</creatorcontrib><creatorcontrib>SCHOLS, L</creatorcontrib><creatorcontrib>SZYMANSKI, S</creatorcontrib><creatorcontrib>VAN DE WARRENBURG, B. P</creatorcontrib><creatorcontrib>BALIKO, L</creatorcontrib><creatorcontrib>DÜRR, A</creatorcontrib><creatorcontrib>KLOCKGETHER, T</creatorcontrib><creatorcontrib>BERCIANO, J</creatorcontrib><creatorcontrib>BOESCH, S</creatorcontrib><creatorcontrib>DEPONDT, C</creatorcontrib><creatorcontrib>GIUNTI, P</creatorcontrib><creatorcontrib>GLOBAS, C</creatorcontrib><creatorcontrib>INFANTE, J</creatorcontrib><creatorcontrib>KANG, J.-S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHMITZ-HÜBSCH, T</au><au>TEZENAS DU MONTCEL, S</au><au>KREMER, B</au><au>MARIOTTI, C</au><au>MELEGH, B</au><au>PANDOLFO, M</au><au>RAKOWICZ, M</au><au>RIBAI, P</au><au>ROLA, R</au><au>SCHOLS, L</au><au>SZYMANSKI, S</au><au>VAN DE WARRENBURG, B. P</au><au>BALIKO, L</au><au>DÜRR, A</au><au>KLOCKGETHER, T</au><au>BERCIANO, J</au><au>BOESCH, S</au><au>DEPONDT, C</au><au>GIUNTI, P</au><au>GLOBAS, C</au><au>INFANTE, J</au><au>KANG, J.-S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scale for the assessment and rating of ataxia : Development of a new clinical scale</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2006-06-13</date><risdate>2006</risdate><volume>66</volume><issue>11</issue><spage>1717</spage><epage>1720</epage><pages>1717-1720</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>To develop a reliable and valid clinical scale measuring the severity of ataxia.
The authors devised the Scale for the Assessment and Rating of Ataxia (SARA) and tested it in two trials of 167 and 119 patients with spinocerebellar ataxia.
The mean time to administer SARA in patients was 14.2 +/- 7.5 minutes (range 5 to 40). Interrater reliability was high, with an intraclass coefficient (ICC) of 0.98. Test-retest reliability was high with an ICC of 0.90. Internal consistency was high as indicated by Cronbach's alpha of 0.94. Factorial analysis revealed that the rating results were determined by a single factor. SARA ratings showed a linear relation to global assessments using a visual analogue scale, suggesting linearity of the scale (p < 0.0001, r(2) = 0.98). SARA score increased with the disease stage (p < 0.001) and was closely correlated with the Barthel Index (r = -0.80, p < 0.001) and part IV (functional assessment) of the Unified Huntington's Disease Rating Scale (UHDRS-IV) (r = -0.89, p < 0.0001), whereas it had only a weak correlation with disease duration (r = 0.34, p < 0.0002).
The Scale for the Assessment and Rating of Ataxia is a reliable and valid measure of ataxia, making it an appropriate primary outcome measure for clinical trials.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16769946</pmid><doi>10.1212/01.wnl.0000219042.60538.92</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neurology, 2006-06, Vol.66 (11), p.1717-1720 |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Development. Senescence. Regeneration. Transplantation Female Fundamental and applied biological sciences. Psychology Health Status Indicators Humans Male Medical sciences Middle Aged Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurologic Examination - methods Neurology Outcome Assessment (Health Care) - methods Reproducibility of Results Sensitivity and Specificity Severity of Illness Index Spinocerebellar Ataxias - classification Spinocerebellar Ataxias - diagnosis Vertebrates: nervous system and sense organs |
| title | Scale for the assessment and rating of ataxia : Development of a new clinical scale |
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