PKD at the crossroads of DAG and PKC signaling

Diacylglycerol (DAG) and its primary target protein kinase C (PKC) regulate many important cellular responses, yet the molecular mechanisms that control the specificity of DAG and PKC signaling are not fully understood. As such, targeting the PKC pathway for therapeutic purposes has been challenging...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2006-06, Vol.27 (6), p.317-323
1. Verfasser:	Wang, Qiming J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diglycerides - metabolism Drug Design Humans Isoenzymes - antagonists & inhibitors Isoenzymes - chemistry Isoenzymes - metabolism Molecular Structure Protein Conformation Protein Kinase C - antagonists & inhibitors Protein Kinase C - chemistry Protein Kinase C - metabolism Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein Transport Signal Transduction
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