EFFECT OF AGE ON PROGNOSIS IN PATIENTS WITH GASTRIC CANCER
Background: The incidence of gastric cancer among the elderly has recently been increasing; however, the prognostic value of age in patients with gastric cancer remains elusive. Methods: A total of 1473 patients with gastric cancer, who had undergone curative gastrectomy were reviewed to investiga...
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| Veröffentlicht in: | ANZ journal of surgery 2006-06, Vol.76 (6), p.458-461 |
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| container_title | ANZ journal of surgery |
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| creator | Saito, Hiroaki Osaki, Tomohiro Murakami, Daiki Sakamoto, Teruhisa Kanaji, Shingo Tatebe, Shigeru Tsujitani, Shunichi Ikeguchi, Masahide |
| description | Background: The incidence of gastric cancer among the elderly has recently been increasing; however, the prognostic value of age in patients with gastric cancer remains elusive.
Methods: A total of 1473 patients with gastric cancer, who had undergone curative gastrectomy were reviewed to investigate the prognostic significance of age.
Results: Blood vessel invasion and differentiated type were more frequently observed in elderly than nonelderly patients (P |
| doi_str_mv | 10.1111/j.1445-2197.2006.03756.x |
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Methods: A total of 1473 patients with gastric cancer, who had undergone curative gastrectomy were reviewed to investigate the prognostic significance of age.
Results: Blood vessel invasion and differentiated type were more frequently observed in elderly than nonelderly patients (P < 0.0001) and elderly patients underwent limited lymph node dissection compared with nonelderly patients (P < 0.001). Moreover, chemotherapy was carried out in nonelderly patients more frequently than in elderly patients (P < 0.005). Ten‐year survival rates were 70.2 and 81.4% in elderly and nonelderly patients, respectively, and the differences were statistically significant (P < 0.001). Postoperative mortality rates were 3.2 and 2.0% in elderly and nonelderly patients, respectively. Hematogenous recurrence was more frequently observed in elderly patients than nonelderly patients (P < 0.05). Multivariate analysis showed that age was an independent prognostic factor.
Conclusions: Age clinically serves as a simple predictor of survival in patients with gastric cancer and should be taken into account along with conventional clinicopathological variables such as depth of invasion and lymph node metastasis.</description><identifier>ISSN: 1445-1433</identifier><identifier>EISSN: 1445-2197</identifier><identifier>DOI: 10.1111/j.1445-2197.2006.03756.x</identifier><identifier>PMID: 16768768</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Adolescent ; Adult ; age ; Age Factors ; Aged ; Aged, 80 and over ; Female ; Gastrectomy ; gastric cancer ; hematogenous recurrence ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; prognosis ; Retrospective Studies ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Survival Rate ; Treatment Outcome</subject><ispartof>ANZ journal of surgery, 2006-06, Vol.76 (6), p.458-461</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4056-2f39377f44c1f02288f09d5cdd7dac60e73450fb4576665fe596f54407d1b96d3</citedby><cites>FETCH-LOGICAL-c4056-2f39377f44c1f02288f09d5cdd7dac60e73450fb4576665fe596f54407d1b96d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1445-2197.2006.03756.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1445-2197.2006.03756.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16768768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saito, Hiroaki</creatorcontrib><creatorcontrib>Osaki, Tomohiro</creatorcontrib><creatorcontrib>Murakami, Daiki</creatorcontrib><creatorcontrib>Sakamoto, Teruhisa</creatorcontrib><creatorcontrib>Kanaji, Shingo</creatorcontrib><creatorcontrib>Tatebe, Shigeru</creatorcontrib><creatorcontrib>Tsujitani, Shunichi</creatorcontrib><creatorcontrib>Ikeguchi, Masahide</creatorcontrib><title>EFFECT OF AGE ON PROGNOSIS IN PATIENTS WITH GASTRIC CANCER</title><title>ANZ journal of surgery</title><addtitle>ANZ J Surg</addtitle><description>Background: The incidence of gastric cancer among the elderly has recently been increasing; however, the prognostic value of age in patients with gastric cancer remains elusive.
Methods: A total of 1473 patients with gastric cancer, who had undergone curative gastrectomy were reviewed to investigate the prognostic significance of age.
Results: Blood vessel invasion and differentiated type were more frequently observed in elderly than nonelderly patients (P < 0.0001) and elderly patients underwent limited lymph node dissection compared with nonelderly patients (P < 0.001). Moreover, chemotherapy was carried out in nonelderly patients more frequently than in elderly patients (P < 0.005). Ten‐year survival rates were 70.2 and 81.4% in elderly and nonelderly patients, respectively, and the differences were statistically significant (P < 0.001). Postoperative mortality rates were 3.2 and 2.0% in elderly and nonelderly patients, respectively. Hematogenous recurrence was more frequently observed in elderly patients than nonelderly patients (P < 0.05). Multivariate analysis showed that age was an independent prognostic factor.
Conclusions: Age clinically serves as a simple predictor of survival in patients with gastric cancer and should be taken into account along with conventional clinicopathological variables such as depth of invasion and lymph node metastasis.</description><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Adolescent</subject><subject>Adult</subject><subject>age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>gastric cancer</subject><subject>hematogenous recurrence</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>prognosis</subject><subject>Retrospective Studies</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>1445-1433</issn><issn>1445-2197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1LwzAUhoMozq-_ILnyrjVpkpNW8KKUriuOVtaKl6FrE9jcnDYO5783dUNvDYGcQ573HHgQwpT41J3bpU85F15AI-kHhIBPmBTg747Q2e_H8aGmnLEROrd2SQgFiMQpGlGQELp7hu7S8ThNalyOcZyluCzw46zMirLKK5y7Jq7ztKgr_JzXE5zFVT3LE5zERZLOLtGJaVZWXx3eC_Q0Tutk4k3LLE_iqddyIsALDIuYlIbzlhoSBGFoSNSJtutk17RAtGRcEDPnQgKAMFpEYATnRHZ0HkHHLtDNfu5bv3nfavuh1gvb6tWqedWbrVUQEkmkDBwY7sG231jba6Pe-sW66b8UJWrwppZqUKIGPWrwpn68qZ2LXh92bOdr3f0FD6IccL8HPhcr_fXvwSouqqFyeW-fX9gPvfvNN_2LAukI9VxkCibAHkLXEPYNA4-DHA</recordid><startdate>200606</startdate><enddate>200606</enddate><creator>Saito, Hiroaki</creator><creator>Osaki, Tomohiro</creator><creator>Murakami, Daiki</creator><creator>Sakamoto, Teruhisa</creator><creator>Kanaji, Shingo</creator><creator>Tatebe, Shigeru</creator><creator>Tsujitani, Shunichi</creator><creator>Ikeguchi, Masahide</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200606</creationdate><title>EFFECT OF AGE ON PROGNOSIS IN PATIENTS WITH GASTRIC CANCER</title><author>Saito, Hiroaki ; Osaki, Tomohiro ; Murakami, Daiki ; Sakamoto, Teruhisa ; Kanaji, Shingo ; Tatebe, Shigeru ; Tsujitani, Shunichi ; Ikeguchi, Masahide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4056-2f39377f44c1f02288f09d5cdd7dac60e73450fb4576665fe596f54407d1b96d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Adolescent</topic><topic>Adult</topic><topic>age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>gastric cancer</topic><topic>hematogenous recurrence</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>prognosis</topic><topic>Retrospective Studies</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saito, Hiroaki</creatorcontrib><creatorcontrib>Osaki, Tomohiro</creatorcontrib><creatorcontrib>Murakami, Daiki</creatorcontrib><creatorcontrib>Sakamoto, Teruhisa</creatorcontrib><creatorcontrib>Kanaji, Shingo</creatorcontrib><creatorcontrib>Tatebe, Shigeru</creatorcontrib><creatorcontrib>Tsujitani, Shunichi</creatorcontrib><creatorcontrib>Ikeguchi, Masahide</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ANZ journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saito, Hiroaki</au><au>Osaki, Tomohiro</au><au>Murakami, Daiki</au><au>Sakamoto, Teruhisa</au><au>Kanaji, Shingo</au><au>Tatebe, Shigeru</au><au>Tsujitani, Shunichi</au><au>Ikeguchi, Masahide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECT OF AGE ON PROGNOSIS IN PATIENTS WITH GASTRIC CANCER</atitle><jtitle>ANZ journal of surgery</jtitle><addtitle>ANZ J Surg</addtitle><date>2006-06</date><risdate>2006</risdate><volume>76</volume><issue>6</issue><spage>458</spage><epage>461</epage><pages>458-461</pages><issn>1445-1433</issn><eissn>1445-2197</eissn><abstract>Background: The incidence of gastric cancer among the elderly has recently been increasing; however, the prognostic value of age in patients with gastric cancer remains elusive.
Methods: A total of 1473 patients with gastric cancer, who had undergone curative gastrectomy were reviewed to investigate the prognostic significance of age.
Results: Blood vessel invasion and differentiated type were more frequently observed in elderly than nonelderly patients (P < 0.0001) and elderly patients underwent limited lymph node dissection compared with nonelderly patients (P < 0.001). Moreover, chemotherapy was carried out in nonelderly patients more frequently than in elderly patients (P < 0.005). Ten‐year survival rates were 70.2 and 81.4% in elderly and nonelderly patients, respectively, and the differences were statistically significant (P < 0.001). Postoperative mortality rates were 3.2 and 2.0% in elderly and nonelderly patients, respectively. Hematogenous recurrence was more frequently observed in elderly patients than nonelderly patients (P < 0.05). Multivariate analysis showed that age was an independent prognostic factor.
Conclusions: Age clinically serves as a simple predictor of survival in patients with gastric cancer and should be taken into account along with conventional clinicopathological variables such as depth of invasion and lymph node metastasis.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>16768768</pmid><doi>10.1111/j.1445-2197.2006.03756.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - surgery Adolescent Adult age Age Factors Aged Aged, 80 and over Female Gastrectomy gastric cancer hematogenous recurrence Humans Male Middle Aged Neoplasm Invasiveness prognosis Retrospective Studies Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach Neoplasms - surgery Survival Rate Treatment Outcome |
| title | EFFECT OF AGE ON PROGNOSIS IN PATIENTS WITH GASTRIC CANCER |
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