Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis
Toll-like receptor 4 (TLR4) is a receptor for bacterial lipopolysaccharide, which is suggested to be involved in the pathogenesis of disease of hepatobiliary tracts. To explore a possible role for this receptor in primary biliary cirrhosis (PBC), we investigated the expression of TLR4 in liver tissu...
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| Veröffentlicht in: | Journal of autoimmunity 2005-08, Vol.25 (1), p.85-91 |
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| creator | Wang, Ai-Ping Migita, Kiyoshi Ito, Masahiro Takii, Yasushi Daikoku, Manabu Yokoyama, Terufumi Komori, Atsumasa Nakamura, Minoru Yatsuhashi, Hiroshi Ishibashi, Hiromi |
| description | Toll-like receptor 4 (TLR4) is a receptor for bacterial lipopolysaccharide, which is suggested to be involved in the pathogenesis of disease of hepatobiliary tracts. To explore a possible role for this receptor in primary biliary cirrhosis (PBC), we investigated the expression of TLR4 in liver tissues from PBC patients. We studied liver biopsy sections from 62 PBC patients and 41 patients with chronic hepatitis C (CHC). Expression of TLR4 in paraffin-embedded sections was analyzed by immunohistochemistry. The bile duct epithelial cells (BECs) of PBC liver tissues markedly expressed TLR4, whereas BECs of CHC liver tissues barely expressed TLR4. The TLR4 expression was also observed in periportal hepatocytes of PBC liver tissues and its expression was extended to interlobular hepatocytes in advanced stage PBC. Although periportal hepatocytes of CHC liver tissues expressed TLR4, its expression levels were not correlated with the fibrosis stage. Our data demonstrated that TLR4 was expressed in BECs and periportal hepatocytes in PBC livers, suggesting the possible involvement of bacterial pathogens and TLR4 in the inflammatory processes of PBC. |
| doi_str_mv | 10.1016/j.jaut.2005.05.003 |
| format | Article |
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To explore a possible role for this receptor in primary biliary cirrhosis (PBC), we investigated the expression of TLR4 in liver tissues from PBC patients. We studied liver biopsy sections from 62 PBC patients and 41 patients with chronic hepatitis C (CHC). Expression of TLR4 in paraffin-embedded sections was analyzed by immunohistochemistry. The bile duct epithelial cells (BECs) of PBC liver tissues markedly expressed TLR4, whereas BECs of CHC liver tissues barely expressed TLR4. The TLR4 expression was also observed in periportal hepatocytes of PBC liver tissues and its expression was extended to interlobular hepatocytes in advanced stage PBC. Although periportal hepatocytes of CHC liver tissues expressed TLR4, its expression levels were not correlated with the fibrosis stage. Our data demonstrated that TLR4 was expressed in BECs and periportal hepatocytes in PBC livers, suggesting the possible involvement of bacterial pathogens and TLR4 in the inflammatory processes of PBC.</description><identifier>ISSN: 0896-8411</identifier><identifier>EISSN: 1095-9157</identifier><identifier>DOI: 10.1016/j.jaut.2005.05.003</identifier><identifier>PMID: 16006099</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Bile duct epithelial cells ; Bile Ducts - metabolism ; Bile Ducts - pathology ; Biological and medical sciences ; Disease Progression ; Epithelium - metabolism ; Epithelium - pathology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; General aspects ; Humans ; Immunopathology ; Lipopolysaccharide ; Liver - metabolism ; Liver - pathology ; Liver Cirrhosis, Biliary - genetics ; Liver Cirrhosis, Biliary - metabolism ; Liver Cirrhosis, Biliary - pathology ; Medical sciences ; Membrane Glycoproteins - biosynthesis ; Membrane Glycoproteins - genetics ; Primary biliary cirrhosis ; Receptors, Cell Surface - biosynthesis ; Receptors, Cell Surface - genetics ; Toll-Like Receptor 4 ; Toll-Like Receptors</subject><ispartof>Journal of autoimmunity, 2005-08, Vol.25 (1), p.85-91</ispartof><rights>2005 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-f4877b69032dfddf8ad5a3dd3ee912ec289a95c0817c0af224749fa5cd75816f3</citedby><cites>FETCH-LOGICAL-c481t-f4877b69032dfddf8ad5a3dd3ee912ec289a95c0817c0af224749fa5cd75816f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaut.2005.05.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16982962$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16006099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Ai-Ping</creatorcontrib><creatorcontrib>Migita, Kiyoshi</creatorcontrib><creatorcontrib>Ito, Masahiro</creatorcontrib><creatorcontrib>Takii, Yasushi</creatorcontrib><creatorcontrib>Daikoku, Manabu</creatorcontrib><creatorcontrib>Yokoyama, Terufumi</creatorcontrib><creatorcontrib>Komori, Atsumasa</creatorcontrib><creatorcontrib>Nakamura, Minoru</creatorcontrib><creatorcontrib>Yatsuhashi, Hiroshi</creatorcontrib><creatorcontrib>Ishibashi, Hiromi</creatorcontrib><title>Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis</title><title>Journal of autoimmunity</title><addtitle>J Autoimmun</addtitle><description>Toll-like receptor 4 (TLR4) is a receptor for bacterial lipopolysaccharide, which is suggested to be involved in the pathogenesis of disease of hepatobiliary tracts. To explore a possible role for this receptor in primary biliary cirrhosis (PBC), we investigated the expression of TLR4 in liver tissues from PBC patients. We studied liver biopsy sections from 62 PBC patients and 41 patients with chronic hepatitis C (CHC). Expression of TLR4 in paraffin-embedded sections was analyzed by immunohistochemistry. The bile duct epithelial cells (BECs) of PBC liver tissues markedly expressed TLR4, whereas BECs of CHC liver tissues barely expressed TLR4. The TLR4 expression was also observed in periportal hepatocytes of PBC liver tissues and its expression was extended to interlobular hepatocytes in advanced stage PBC. Although periportal hepatocytes of CHC liver tissues expressed TLR4, its expression levels were not correlated with the fibrosis stage. Our data demonstrated that TLR4 was expressed in BECs and periportal hepatocytes in PBC livers, suggesting the possible involvement of bacterial pathogens and TLR4 in the inflammatory processes of PBC.</description><subject>Bile duct epithelial cells</subject><subject>Bile Ducts - metabolism</subject><subject>Bile Ducts - pathology</subject><subject>Biological and medical sciences</subject><subject>Disease Progression</subject><subject>Epithelium - metabolism</subject><subject>Epithelium - pathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Lipopolysaccharide</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver Cirrhosis, Biliary - genetics</subject><subject>Liver Cirrhosis, Biliary - metabolism</subject><subject>Liver Cirrhosis, Biliary - pathology</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - biosynthesis</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Primary biliary cirrhosis</subject><subject>Receptors, Cell Surface - biosynthesis</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Toll-Like Receptor 4</subject><subject>Toll-Like Receptors</subject><issn>0896-8411</issn><issn>1095-9157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo7rj6BzxIX_TWY1W68wVeZNFdYcGLnkMmqWDGnk6b9Ij77-1mGvSkUPBenvp6GHuJsEdA-fa4P7rzvOcAYr8WdI_YDsGI1qBQj9kOtJGt7hGv2LNajwCIQoin7AolgARjduz2jiY3J9_Qr6lQrSmPTY7NnIehHdJ3agp5muZcmr5JYzOVdHLloTmkIa3pUynfck31OXsS3VDpxZbX7OvHD19u7tr7z7efbt7ft77XOLex10odpIGOhxhC1C4I14XQERnk5Lk2zggPGpUHFznvVW-iEz4ooVHG7pq9ucydSv5xpjrbU6qehsGNlM_VSg0KhIL_gqiE1BL5AvIL6EuutVC025MWwa6e7dGunu3q2a4F3dL0apt-Ppwo_GnZxC7A6w1w1bshFjf6VP_ijOZGrtvfXThapP1MVGz1iUZPIS3mZxty-tcdvwFRfpul</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Wang, Ai-Ping</creator><creator>Migita, Kiyoshi</creator><creator>Ito, Masahiro</creator><creator>Takii, Yasushi</creator><creator>Daikoku, Manabu</creator><creator>Yokoyama, Terufumi</creator><creator>Komori, Atsumasa</creator><creator>Nakamura, Minoru</creator><creator>Yatsuhashi, Hiroshi</creator><creator>Ishibashi, Hiromi</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis</title><author>Wang, Ai-Ping ; Migita, Kiyoshi ; Ito, Masahiro ; Takii, Yasushi ; Daikoku, Manabu ; Yokoyama, Terufumi ; Komori, Atsumasa ; Nakamura, Minoru ; Yatsuhashi, Hiroshi ; Ishibashi, Hiromi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-f4877b69032dfddf8ad5a3dd3ee912ec289a95c0817c0af224749fa5cd75816f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Bile duct epithelial cells</topic><topic>Bile Ducts - metabolism</topic><topic>Bile Ducts - pathology</topic><topic>Biological and medical sciences</topic><topic>Disease Progression</topic><topic>Epithelium - metabolism</topic><topic>Epithelium - pathology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>General aspects</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Lipopolysaccharide</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver Cirrhosis, Biliary - genetics</topic><topic>Liver Cirrhosis, Biliary - metabolism</topic><topic>Liver Cirrhosis, Biliary - pathology</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - biosynthesis</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Primary biliary cirrhosis</topic><topic>Receptors, Cell Surface - biosynthesis</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Toll-Like Receptor 4</topic><topic>Toll-Like Receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Ai-Ping</creatorcontrib><creatorcontrib>Migita, Kiyoshi</creatorcontrib><creatorcontrib>Ito, Masahiro</creatorcontrib><creatorcontrib>Takii, Yasushi</creatorcontrib><creatorcontrib>Daikoku, Manabu</creatorcontrib><creatorcontrib>Yokoyama, Terufumi</creatorcontrib><creatorcontrib>Komori, Atsumasa</creatorcontrib><creatorcontrib>Nakamura, Minoru</creatorcontrib><creatorcontrib>Yatsuhashi, Hiroshi</creatorcontrib><creatorcontrib>Ishibashi, Hiromi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of autoimmunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Ai-Ping</au><au>Migita, Kiyoshi</au><au>Ito, Masahiro</au><au>Takii, Yasushi</au><au>Daikoku, Manabu</au><au>Yokoyama, Terufumi</au><au>Komori, Atsumasa</au><au>Nakamura, Minoru</au><au>Yatsuhashi, Hiroshi</au><au>Ishibashi, Hiromi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis</atitle><jtitle>Journal of autoimmunity</jtitle><addtitle>J Autoimmun</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>25</volume><issue>1</issue><spage>85</spage><epage>91</epage><pages>85-91</pages><issn>0896-8411</issn><eissn>1095-9157</eissn><abstract>Toll-like receptor 4 (TLR4) is a receptor for bacterial lipopolysaccharide, which is suggested to be involved in the pathogenesis of disease of hepatobiliary tracts. To explore a possible role for this receptor in primary biliary cirrhosis (PBC), we investigated the expression of TLR4 in liver tissues from PBC patients. We studied liver biopsy sections from 62 PBC patients and 41 patients with chronic hepatitis C (CHC). Expression of TLR4 in paraffin-embedded sections was analyzed by immunohistochemistry. The bile duct epithelial cells (BECs) of PBC liver tissues markedly expressed TLR4, whereas BECs of CHC liver tissues barely expressed TLR4. The TLR4 expression was also observed in periportal hepatocytes of PBC liver tissues and its expression was extended to interlobular hepatocytes in advanced stage PBC. Although periportal hepatocytes of CHC liver tissues expressed TLR4, its expression levels were not correlated with the fibrosis stage. 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| subjects | Bile duct epithelial cells Bile Ducts - metabolism Bile Ducts - pathology Biological and medical sciences Disease Progression Epithelium - metabolism Epithelium - pathology Fundamental and applied biological sciences. Psychology Fundamental immunology General aspects Humans Immunopathology Lipopolysaccharide Liver - metabolism Liver - pathology Liver Cirrhosis, Biliary - genetics Liver Cirrhosis, Biliary - metabolism Liver Cirrhosis, Biliary - pathology Medical sciences Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Primary biliary cirrhosis Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - genetics Toll-Like Receptor 4 Toll-Like Receptors |
| title | Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis |
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