The clinical utility of structural neuroimaging with MRI for diagnosis and differential diagnosis of dementia: a memory clinic study
Objectives The individual contribution to the final comprehensive clinical diagnosis of neuropsychology (NP) and magnetic resonance imaging (MRI), respectively, was quantified in a specialized tertiary care setting to investigate the added clinical value of routine MRI. Methods In 106 patients refer...
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| Veröffentlicht in: | International journal of geriatric psychiatry 2005-07, Vol.20 (7), p.645-650 |
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| container_title | International journal of geriatric psychiatry |
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| creator | Hentschel, F. Kreis, M. Damian, M. Krumm, B. Frölich, L. |
| description | Objectives
The individual contribution to the final comprehensive clinical diagnosis of neuropsychology (NP) and magnetic resonance imaging (MRI), respectively, was quantified in a specialized tertiary care setting to investigate the added clinical value of routine MRI.
Methods
In 106 patients referred to a university memory clinic for the work‐up of cognitive disturbances the primary care diagnosis, the initial clinical neuropsychiatric diagnosis, the neuropsychological and MRI diagnoses, and the final comprehensive clinical diagnosis were documented. The neuropsychological investigation was performed using the CERAD test battery. MRI was performed using T1, double echo and FLAIR sequences without contrast medium. The change of the final comprehensive clinical diagnosis in relation to the initial neuropsychiatric diagnosis was used to determine the diagnostic contribution of both, MRI and NP.
Results
NP and MRI led to a significant change of the final comprehensive diagnosis in 26% of patients (CI: 0.26 ± 0.09; p |
| doi_str_mv | 10.1002/gps.1333 |
| format | Article |
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The individual contribution to the final comprehensive clinical diagnosis of neuropsychology (NP) and magnetic resonance imaging (MRI), respectively, was quantified in a specialized tertiary care setting to investigate the added clinical value of routine MRI.
Methods
In 106 patients referred to a university memory clinic for the work‐up of cognitive disturbances the primary care diagnosis, the initial clinical neuropsychiatric diagnosis, the neuropsychological and MRI diagnoses, and the final comprehensive clinical diagnosis were documented. The neuropsychological investigation was performed using the CERAD test battery. MRI was performed using T1, double echo and FLAIR sequences without contrast medium. The change of the final comprehensive clinical diagnosis in relation to the initial neuropsychiatric diagnosis was used to determine the diagnostic contribution of both, MRI and NP.
Results
NP and MRI led to a significant change of the final comprehensive diagnosis in 26% of patients (CI: 0.26 ± 0.09; p < 0.05). In addition, three cases of secondary dementias, and six cases of vascular encephalopathy without dementia were recognized by MRI. Sensitivity, specificity, and the positive predictive value were higher for NP and MRI, respectively, than for the initial clinical diagnosis alone.
Conclusion
MRI as well as neuropsychological testing improves early detection and differential diagnosis of dementia and additionally supplies clinically relevant findings. MRI carries added clinical value in the investigation of dementias. Copyright © 2005 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.1333</identifier><identifier>PMID: 16021656</identifier><identifier>CODEN: IJGPES</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - diagnosis ; Biological and medical sciences ; Brain - pathology ; CERAD test battery ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia ; Dementia - diagnosis ; Dementia, Vascular - diagnosis ; Diagnosis, Differential ; diagnostic accuracy ; diagnostics ; Fundamental and applied biological sciences. Psychology ; Geriatric psychiatry ; Geriatrics ; Humans ; Lewy Body Disease - diagnosis ; Magnetic Resonance Imaging - methods ; Medical diagnosis ; Medical sciences ; Middle Aged ; MRI ; neuroimaging ; Neurology ; Neuropsychological Tests ; neuropsychology ; NMR ; Nuclear magnetic resonance ; Psychiatry ; Psychoanalysis ; Psychology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; sensitivity ; Sensitivity and Specificity ; specificity</subject><ispartof>International journal of geriatric psychiatry, 2005-07, Vol.20 (7), p.645-650</ispartof><rights>Copyright © 2005 John Wiley & Sons, Ltd.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright 2005 John Wiley & Sons, Ltd.</rights><rights>Copyright John Wiley and Sons, Limited Jul 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4453-4af3cea267e38409543579959a2995465066a35619fdb38c3d774e8408202eb13</citedby><cites>FETCH-LOGICAL-c4453-4af3cea267e38409543579959a2995465066a35619fdb38c3d774e8408202eb13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.1333$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.1333$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17007316$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16021656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hentschel, F.</creatorcontrib><creatorcontrib>Kreis, M.</creatorcontrib><creatorcontrib>Damian, M.</creatorcontrib><creatorcontrib>Krumm, B.</creatorcontrib><creatorcontrib>Frölich, L.</creatorcontrib><title>The clinical utility of structural neuroimaging with MRI for diagnosis and differential diagnosis of dementia: a memory clinic study</title><title>International journal of geriatric psychiatry</title><addtitle>Int. J. Geriat. Psychiatry</addtitle><description>Objectives
The individual contribution to the final comprehensive clinical diagnosis of neuropsychology (NP) and magnetic resonance imaging (MRI), respectively, was quantified in a specialized tertiary care setting to investigate the added clinical value of routine MRI.
Methods
In 106 patients referred to a university memory clinic for the work‐up of cognitive disturbances the primary care diagnosis, the initial clinical neuropsychiatric diagnosis, the neuropsychological and MRI diagnoses, and the final comprehensive clinical diagnosis were documented. The neuropsychological investigation was performed using the CERAD test battery. MRI was performed using T1, double echo and FLAIR sequences without contrast medium. The change of the final comprehensive clinical diagnosis in relation to the initial neuropsychiatric diagnosis was used to determine the diagnostic contribution of both, MRI and NP.
Results
NP and MRI led to a significant change of the final comprehensive diagnosis in 26% of patients (CI: 0.26 ± 0.09; p < 0.05). In addition, three cases of secondary dementias, and six cases of vascular encephalopathy without dementia were recognized by MRI. Sensitivity, specificity, and the positive predictive value were higher for NP and MRI, respectively, than for the initial clinical diagnosis alone.
Conclusion
MRI as well as neuropsychological testing improves early detection and differential diagnosis of dementia and additionally supplies clinically relevant findings. MRI carries added clinical value in the investigation of dementias. Copyright © 2005 John Wiley & Sons, Ltd.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>CERAD test battery</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dementia</subject><subject>Dementia - diagnosis</subject><subject>Dementia, Vascular - diagnosis</subject><subject>Diagnosis, Differential</subject><subject>diagnostic accuracy</subject><subject>diagnostics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Geriatric psychiatry</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Lewy Body Disease - diagnosis</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>neuroimaging</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>neuropsychology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Psychiatry</subject><subject>Psychoanalysis</subject><subject>Psychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>sensitivity</subject><subject>Sensitivity and Specificity</subject><subject>specificity</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFDEUxYModlsFP4EEweLL1Jtkksz0TYpui-sfasXHkM0k29SZzJrMUOfdD27aHVwQxJeE3PvLOdx7EHpG4IQA0NebbTohjLEHaEGgrgtChHiIFlBVvBCUwQE6TOkGIPdI9RgdEAGUCC4W6NfVtcWm9cEb3eJx8K0fJtw7nIY4mmGMuRrsGHvf6Y0PG3zrh2v84fICuz7ixutN6JNPWIcmv5yz0YbB50_7VhZrbHdfPsUad7br4zR7ZpuxmZ6gR063yT6d7yP09d3bq7PzYvVpeXH2ZlWYsuSsKLVjxmoqpGVVCTUvGZd1zWtN81kKDkJoxgWpXbNmlWGNlKXNZEWB2jVhR-h4p7uN_Y_RpkF1PhnbtjrYfkxKVCCBC_FfkBJSEilkBl_8Bd70Ywx5CEUpcFLnNWfo1Q4ysU8pWqe2Ma8zToqAustP5fzUXX4ZfT7rjevONntwDiwDL2dAp5yYizoYn_acBJDs3rPYcbe-tdM_DdXy85fZeOZ9GuzPP7yO31UeU3L17eNSEfp-CeerS7VivwEuk79i</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Hentschel, F.</creator><creator>Kreis, M.</creator><creator>Damian, M.</creator><creator>Krumm, B.</creator><creator>Frölich, L.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200507</creationdate><title>The clinical utility of structural neuroimaging with MRI for diagnosis and differential diagnosis of dementia: a memory clinic study</title><author>Hentschel, F. ; Kreis, M. ; Damian, M. ; Krumm, B. ; Frölich, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4453-4af3cea267e38409543579959a2995465066a35619fdb38c3d774e8408202eb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>CERAD test battery</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dementia</topic><topic>Dementia - diagnosis</topic><topic>Dementia, Vascular - diagnosis</topic><topic>Diagnosis, Differential</topic><topic>diagnostic accuracy</topic><topic>diagnostics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Geriatric psychiatry</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Lewy Body Disease - diagnosis</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>neuroimaging</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>neuropsychology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Psychiatry</topic><topic>Psychoanalysis</topic><topic>Psychology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>sensitivity</topic><topic>Sensitivity and Specificity</topic><topic>specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hentschel, F.</creatorcontrib><creatorcontrib>Kreis, M.</creatorcontrib><creatorcontrib>Damian, M.</creatorcontrib><creatorcontrib>Krumm, B.</creatorcontrib><creatorcontrib>Frölich, L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hentschel, F.</au><au>Kreis, M.</au><au>Damian, M.</au><au>Krumm, B.</au><au>Frölich, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical utility of structural neuroimaging with MRI for diagnosis and differential diagnosis of dementia: a memory clinic study</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int. J. Geriat. Psychiatry</addtitle><date>2005-07</date><risdate>2005</risdate><volume>20</volume><issue>7</issue><spage>645</spage><epage>650</epage><pages>645-650</pages><issn>0885-6230</issn><eissn>1099-1166</eissn><coden>IJGPES</coden><abstract>Objectives
The individual contribution to the final comprehensive clinical diagnosis of neuropsychology (NP) and magnetic resonance imaging (MRI), respectively, was quantified in a specialized tertiary care setting to investigate the added clinical value of routine MRI.
Methods
In 106 patients referred to a university memory clinic for the work‐up of cognitive disturbances the primary care diagnosis, the initial clinical neuropsychiatric diagnosis, the neuropsychological and MRI diagnoses, and the final comprehensive clinical diagnosis were documented. The neuropsychological investigation was performed using the CERAD test battery. MRI was performed using T1, double echo and FLAIR sequences without contrast medium. The change of the final comprehensive clinical diagnosis in relation to the initial neuropsychiatric diagnosis was used to determine the diagnostic contribution of both, MRI and NP.
Results
NP and MRI led to a significant change of the final comprehensive diagnosis in 26% of patients (CI: 0.26 ± 0.09; p < 0.05). In addition, three cases of secondary dementias, and six cases of vascular encephalopathy without dementia were recognized by MRI. Sensitivity, specificity, and the positive predictive value were higher for NP and MRI, respectively, than for the initial clinical diagnosis alone.
Conclusion
MRI as well as neuropsychological testing improves early detection and differential diagnosis of dementia and additionally supplies clinically relevant findings. MRI carries added clinical value in the investigation of dementias. Copyright © 2005 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>16021656</pmid><doi>10.1002/gps.1333</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - diagnosis Biological and medical sciences Brain - pathology CERAD test battery Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Dementia - diagnosis Dementia, Vascular - diagnosis Diagnosis, Differential diagnostic accuracy diagnostics Fundamental and applied biological sciences. Psychology Geriatric psychiatry Geriatrics Humans Lewy Body Disease - diagnosis Magnetic Resonance Imaging - methods Medical diagnosis Medical sciences Middle Aged MRI neuroimaging Neurology Neuropsychological Tests neuropsychology NMR Nuclear magnetic resonance Psychiatry Psychoanalysis Psychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry sensitivity Sensitivity and Specificity specificity |
| title | The clinical utility of structural neuroimaging with MRI for diagnosis and differential diagnosis of dementia: a memory clinic study |
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