Soya isoflavone-enriched cereal bars affect markers of endothelial function in postmenopausal women
Soya isoflavones are thought to be cardioprotective due to their structural similarity to oestrogen. In order to investigate the effect of soya isoflavones on markers of endothelial function we conducted a randomised, double-blind, placebo-controlled, cross-over study with thirty healthy postmenopau...
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| Veröffentlicht in: | British journal of nutrition 2006-06, Vol.95 (6), p.1120-1126 |
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| creator | Hallund, J. Bügel, S. Tholstrup, T. Ferrari, M. Talbot, D. Hall, W. L. Reimann, M. Williams, C.M. Wiinberg, N. |
| description | Soya isoflavones are thought to be cardioprotective due to their structural similarity to oestrogen. In order to investigate the effect of soya isoflavones on markers of endothelial function we conducted a randomised, double-blind, placebo-controlled, cross-over study with thirty healthy postmenopausal women. The women consumed cereal bars, with or without soya isoflavones (50mg/d), for 8 weeks, separated by an 8-week washout period. Systemic arterial complince (SAC), isobaric arterial compliance (IAC), flow-mediated endothelium-dependent vasodilation (FMD) and nitroglycerine-mediated endothelium-independent vasodilation (NMD) were measured at the beginning of the study and after each intervention period. Blood pressure (BP) and plasma concentrations of nitrite and nitrate (NOx) and endothelin-1 (ET-1) were measured at the beginning and end of each intervention period.NMD was 13·4 (sem 2·0) % at baseline and 15·5 (sem 1·1) % after isoflavone treatment compared with 12·4 (sem 1·0) % after placebo treatment (P=0·03). NOx increased from 27·7 (sem 2·7) to 31·1 (sem 3·2) μm after isoflavones treatment compared with 25·4 (sem 1·5) to 20·4 (sem 1·1) μm after placebo treatment (P=0·003) and a significant increase in the NOx:ET-1 ratio (P=0·005) was observed after the isoflavone treatment compared with placebo. A significant difference in SAC after the isoflavone and placebo treatment was observed (P=0·04). No significant difference was found in FMD, IAC, BP and ET-1. In conclusion, 8 weeks' consumption of cereals bars enriched with 50mg soya isoflavones/d increased plasma NOx concentrations and improved endothelium-independent vasodilation in healthy postmenopausal women. |
| doi_str_mv | 10.1079/BJN20061734 |
| format | Article |
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L. ; Reimann, M. ; Williams, C.M. ; Wiinberg, N.</creator><creatorcontrib>Hallund, J. ; Bügel, S. ; Tholstrup, T. ; Ferrari, M. ; Talbot, D. ; Hall, W. L. ; Reimann, M. ; Williams, C.M. ; Wiinberg, N.</creatorcontrib><description>Soya isoflavones are thought to be cardioprotective due to their structural similarity to oestrogen. In order to investigate the effect of soya isoflavones on markers of endothelial function we conducted a randomised, double-blind, placebo-controlled, cross-over study with thirty healthy postmenopausal women. The women consumed cereal bars, with or without soya isoflavones (50mg/d), for 8 weeks, separated by an 8-week washout period. Systemic arterial complince (SAC), isobaric arterial compliance (IAC), flow-mediated endothelium-dependent vasodilation (FMD) and nitroglycerine-mediated endothelium-independent vasodilation (NMD) were measured at the beginning of the study and after each intervention period. Blood pressure (BP) and plasma concentrations of nitrite and nitrate (NOx) and endothelin-1 (ET-1) were measured at the beginning and end of each intervention period.NMD was 13·4 (sem 2·0) % at baseline and 15·5 (sem 1·1) % after isoflavone treatment compared with 12·4 (sem 1·0) % after placebo treatment (P=0·03). NOx increased from 27·7 (sem 2·7) to 31·1 (sem 3·2) μm after isoflavones treatment compared with 25·4 (sem 1·5) to 20·4 (sem 1·1) μm after placebo treatment (P=0·003) and a significant increase in the NOx:ET-1 ratio (P=0·005) was observed after the isoflavone treatment compared with placebo. A significant difference in SAC after the isoflavone and placebo treatment was observed (P=0·04). No significant difference was found in FMD, IAC, BP and ET-1. In conclusion, 8 weeks' consumption of cereals bars enriched with 50mg soya isoflavones/d increased plasma NOx concentrations and improved endothelium-independent vasodilation in healthy postmenopausal women.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN20061734</identifier><identifier>PMID: 16768834</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>adults ; Arterial compliance ; arteries ; Biological and medical sciences ; biomarkers ; Biomarkers - blood ; blood chemistry ; Blood pressure ; Brachial Artery - physiology ; Breakfast foods ; cardiovascular agents ; Cardiovascular disease ; cardiovascular health ; cardiovascular system ; Compliance ; Coronary Disease - metabolism ; Coronary Disease - prevention & control ; Denmark ; Endothelial function ; Endothelin-1 - blood ; endothelins ; Endothelium ; Endothelium, Vascular - metabolism ; enriched foods ; Epidemiologic Methods ; estrogens ; Feeding. Feeding behavior ; Female ; Food ; Food, Fortified ; Fundamental and applied biological sciences. Psychology ; Germany ; Glycine max ; Hormone replacement therapy ; Humans ; isoflavones ; Isoflavones - therapeutic use ; Italy ; Menopause ; Menstruation ; Middle Aged ; Muscle, Smooth, Vascular - physiopathology ; Nitrates ; Nitric Oxide - blood ; nitrites ; Nutrition ; Phyto-oestrogens ; Phytotherapy ; Postmenopausal women ; Postmenopause - metabolism ; soybean products ; United Kingdom ; Vascular Resistance ; Vasodilation ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; women ; Womens health</subject><ispartof>British journal of nutrition, 2006-06, Vol.95 (6), p.1120-1126</ispartof><rights>Copyright © The Nutrition Society 2006</rights><rights>2006 INIST-CNRS</rights><rights>The Nutrition Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-d3f0dd5997b124b71725d219d41ca51d17a451d5ab315a2178f0d2ec6e16731c3</citedby><cites>FETCH-LOGICAL-c547t-d3f0dd5997b124b71725d219d41ca51d17a451d5ab315a2178f0d2ec6e16731c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17863369$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16768834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hallund, J.</creatorcontrib><creatorcontrib>Bügel, S.</creatorcontrib><creatorcontrib>Tholstrup, T.</creatorcontrib><creatorcontrib>Ferrari, M.</creatorcontrib><creatorcontrib>Talbot, D.</creatorcontrib><creatorcontrib>Hall, W. L.</creatorcontrib><creatorcontrib>Reimann, M.</creatorcontrib><creatorcontrib>Williams, C.M.</creatorcontrib><creatorcontrib>Wiinberg, N.</creatorcontrib><title>Soya isoflavone-enriched cereal bars affect markers of endothelial function in postmenopausal women</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Soya isoflavones are thought to be cardioprotective due to their structural similarity to oestrogen. In order to investigate the effect of soya isoflavones on markers of endothelial function we conducted a randomised, double-blind, placebo-controlled, cross-over study with thirty healthy postmenopausal women. The women consumed cereal bars, with or without soya isoflavones (50mg/d), for 8 weeks, separated by an 8-week washout period. Systemic arterial complince (SAC), isobaric arterial compliance (IAC), flow-mediated endothelium-dependent vasodilation (FMD) and nitroglycerine-mediated endothelium-independent vasodilation (NMD) were measured at the beginning of the study and after each intervention period. Blood pressure (BP) and plasma concentrations of nitrite and nitrate (NOx) and endothelin-1 (ET-1) were measured at the beginning and end of each intervention period.NMD was 13·4 (sem 2·0) % at baseline and 15·5 (sem 1·1) % after isoflavone treatment compared with 12·4 (sem 1·0) % after placebo treatment (P=0·03). NOx increased from 27·7 (sem 2·7) to 31·1 (sem 3·2) μm after isoflavones treatment compared with 25·4 (sem 1·5) to 20·4 (sem 1·1) μm after placebo treatment (P=0·003) and a significant increase in the NOx:ET-1 ratio (P=0·005) was observed after the isoflavone treatment compared with placebo. A significant difference in SAC after the isoflavone and placebo treatment was observed (P=0·04). No significant difference was found in FMD, IAC, BP and ET-1. In conclusion, 8 weeks' consumption of cereals bars enriched with 50mg soya isoflavones/d increased plasma NOx concentrations and improved endothelium-independent vasodilation in healthy postmenopausal women.</description><subject>adults</subject><subject>Arterial compliance</subject><subject>arteries</subject><subject>Biological and medical sciences</subject><subject>biomarkers</subject><subject>Biomarkers - blood</subject><subject>blood chemistry</subject><subject>Blood pressure</subject><subject>Brachial Artery - physiology</subject><subject>Breakfast foods</subject><subject>cardiovascular agents</subject><subject>Cardiovascular disease</subject><subject>cardiovascular health</subject><subject>cardiovascular system</subject><subject>Compliance</subject><subject>Coronary Disease - metabolism</subject><subject>Coronary Disease - prevention & control</subject><subject>Denmark</subject><subject>Endothelial function</subject><subject>Endothelin-1 - blood</subject><subject>endothelins</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - metabolism</subject><subject>enriched foods</subject><subject>Epidemiologic Methods</subject><subject>estrogens</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Food</subject><subject>Food, Fortified</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Germany</subject><subject>Glycine max</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>isoflavones</subject><subject>Isoflavones - therapeutic use</subject><subject>Italy</subject><subject>Menopause</subject><subject>Menstruation</subject><subject>Middle Aged</subject><subject>Muscle, Smooth, Vascular - physiopathology</subject><subject>Nitrates</subject><subject>Nitric Oxide - blood</subject><subject>nitrites</subject><subject>Nutrition</subject><subject>Phyto-oestrogens</subject><subject>Phytotherapy</subject><subject>Postmenopausal women</subject><subject>Postmenopause - metabolism</subject><subject>soybean products</subject><subject>United Kingdom</subject><subject>Vascular Resistance</subject><subject>Vasodilation</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>women</subject><subject>Womens health</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0E1v1DAQBmALgeiycOIOERJcUMBjJ7ZzhIqWj1IES7lajj1uXbLxYidA_z2udtVFiNNoNI9GMy8hD4G-ACq7l6_fnzJKBUje3CILaGRbMyHYbbKglMoaoGkPyL2cL0urgHZ3yQEIKZTizYLYVbwyVcjRD-ZnHLHGMQV7ga6ymNAMVW9Sroz3aKdqbdJ3LG30FY4uThc4hEL8PNopxLEKY7WJeVrjGDdmzmX0K5bmPrnjzZDxwa4uydnRm6-Hb-uTT8fvDl-d1LZt5FQ77qlzbdfJHljTS5CsdQw614A1LTiQpimlNT2H1jCQqniGVmB5h4PlS_Jsu3eT4o8Z86TXIVscBjNinLMWiopOFbskT_6Bl3FOY7lNM-CKQ0ev0fMtsinmnNDrTQolgSsNVF8Hr_8KvuhHu5Vzv0a3t7ukC3i6AyZbM_hkRhvy3kklOBddcfXWhTzh75t5SV6Xy2WrxfFn_e1InH74smr0x-Ifb703UZvzVHaerRgFToEqJco_NxutWfcpuHPcv_u_V_4ABSiw9g</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>Hallund, J.</creator><creator>Bügel, S.</creator><creator>Tholstrup, T.</creator><creator>Ferrari, M.</creator><creator>Talbot, D.</creator><creator>Hall, W. L.</creator><creator>Reimann, M.</creator><creator>Williams, C.M.</creator><creator>Wiinberg, N.</creator><general>Cambridge University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20060601</creationdate><title>Soya isoflavone-enriched cereal bars affect markers of endothelial function in postmenopausal women</title><author>Hallund, J. ; Bügel, S. ; Tholstrup, T. ; Ferrari, M. ; Talbot, D. ; Hall, W. L. ; Reimann, M. ; Williams, C.M. ; Wiinberg, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-d3f0dd5997b124b71725d219d41ca51d17a451d5ab315a2178f0d2ec6e16731c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>adults</topic><topic>Arterial compliance</topic><topic>arteries</topic><topic>Biological and medical sciences</topic><topic>biomarkers</topic><topic>Biomarkers - blood</topic><topic>blood chemistry</topic><topic>Blood pressure</topic><topic>Brachial Artery - physiology</topic><topic>Breakfast foods</topic><topic>cardiovascular agents</topic><topic>Cardiovascular disease</topic><topic>cardiovascular health</topic><topic>cardiovascular system</topic><topic>Compliance</topic><topic>Coronary Disease - metabolism</topic><topic>Coronary Disease - prevention & control</topic><topic>Denmark</topic><topic>Endothelial function</topic><topic>Endothelin-1 - blood</topic><topic>endothelins</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - metabolism</topic><topic>enriched foods</topic><topic>Epidemiologic Methods</topic><topic>estrogens</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Food</topic><topic>Food, Fortified</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Germany</topic><topic>Glycine max</topic><topic>Hormone replacement therapy</topic><topic>Humans</topic><topic>isoflavones</topic><topic>Isoflavones - therapeutic use</topic><topic>Italy</topic><topic>Menopause</topic><topic>Menstruation</topic><topic>Middle Aged</topic><topic>Muscle, Smooth, Vascular - physiopathology</topic><topic>Nitrates</topic><topic>Nitric Oxide - blood</topic><topic>nitrites</topic><topic>Nutrition</topic><topic>Phyto-oestrogens</topic><topic>Phytotherapy</topic><topic>Postmenopausal women</topic><topic>Postmenopause - metabolism</topic><topic>soybean products</topic><topic>United Kingdom</topic><topic>Vascular Resistance</topic><topic>Vasodilation</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>women</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hallund, J.</creatorcontrib><creatorcontrib>Bügel, S.</creatorcontrib><creatorcontrib>Tholstrup, T.</creatorcontrib><creatorcontrib>Ferrari, M.</creatorcontrib><creatorcontrib>Talbot, D.</creatorcontrib><creatorcontrib>Hall, W. 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L.</au><au>Reimann, M.</au><au>Williams, C.M.</au><au>Wiinberg, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soya isoflavone-enriched cereal bars affect markers of endothelial function in postmenopausal women</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>95</volume><issue>6</issue><spage>1120</spage><epage>1126</epage><pages>1120-1126</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Soya isoflavones are thought to be cardioprotective due to their structural similarity to oestrogen. In order to investigate the effect of soya isoflavones on markers of endothelial function we conducted a randomised, double-blind, placebo-controlled, cross-over study with thirty healthy postmenopausal women. The women consumed cereal bars, with or without soya isoflavones (50mg/d), for 8 weeks, separated by an 8-week washout period. Systemic arterial complince (SAC), isobaric arterial compliance (IAC), flow-mediated endothelium-dependent vasodilation (FMD) and nitroglycerine-mediated endothelium-independent vasodilation (NMD) were measured at the beginning of the study and after each intervention period. Blood pressure (BP) and plasma concentrations of nitrite and nitrate (NOx) and endothelin-1 (ET-1) were measured at the beginning and end of each intervention period.NMD was 13·4 (sem 2·0) % at baseline and 15·5 (sem 1·1) % after isoflavone treatment compared with 12·4 (sem 1·0) % after placebo treatment (P=0·03). NOx increased from 27·7 (sem 2·7) to 31·1 (sem 3·2) μm after isoflavones treatment compared with 25·4 (sem 1·5) to 20·4 (sem 1·1) μm after placebo treatment (P=0·003) and a significant increase in the NOx:ET-1 ratio (P=0·005) was observed after the isoflavone treatment compared with placebo. A significant difference in SAC after the isoflavone and placebo treatment was observed (P=0·04). No significant difference was found in FMD, IAC, BP and ET-1. In conclusion, 8 weeks' consumption of cereals bars enriched with 50mg soya isoflavones/d increased plasma NOx concentrations and improved endothelium-independent vasodilation in healthy postmenopausal women.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>16768834</pmid><doi>10.1079/BJN20061734</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of nutrition, 2006-06, Vol.95 (6), p.1120-1126 |
| issn | 0007-1145 1475-2662 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | adults Arterial compliance arteries Biological and medical sciences biomarkers Biomarkers - blood blood chemistry Blood pressure Brachial Artery - physiology Breakfast foods cardiovascular agents Cardiovascular disease cardiovascular health cardiovascular system Compliance Coronary Disease - metabolism Coronary Disease - prevention & control Denmark Endothelial function Endothelin-1 - blood endothelins Endothelium Endothelium, Vascular - metabolism enriched foods Epidemiologic Methods estrogens Feeding. Feeding behavior Female Food Food, Fortified Fundamental and applied biological sciences. Psychology Germany Glycine max Hormone replacement therapy Humans isoflavones Isoflavones - therapeutic use Italy Menopause Menstruation Middle Aged Muscle, Smooth, Vascular - physiopathology Nitrates Nitric Oxide - blood nitrites Nutrition Phyto-oestrogens Phytotherapy Postmenopausal women Postmenopause - metabolism soybean products United Kingdom Vascular Resistance Vasodilation Vertebrates: anatomy and physiology, studies on body, several organs or systems women Womens health |
| title | Soya isoflavone-enriched cereal bars affect markers of endothelial function in postmenopausal women |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T05%3A04%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Soya%20isoflavone-enriched%20cereal%20bars%20affect%20markers%20of%20endothelial%20function%20in%20postmenopausal%20women&rft.jtitle=British%20journal%20of%20nutrition&rft.au=Hallund,%20J.&rft.date=2006-06-01&rft.volume=95&rft.issue=6&rft.spage=1120&rft.epage=1126&rft.pages=1120-1126&rft.issn=0007-1145&rft.eissn=1475-2662&rft.coden=BJNUAV&rft_id=info:doi/10.1079/BJN20061734&rft_dat=%3Cproquest_cross%3E68069867%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213831907&rft_id=info:pmid/16768834&rft_cupid=10_1079_BJN20061734&rfr_iscdi=true |