High-resolution anatomic, diffusion tensor, and magnetization transfer magnetic resonance imaging of the optic chiasm at 3T
Purpose To evaluate techniques for anatomical and physiological imaging of the intracranial optic nerve (ON), optic chiasm (OC), and optic tract (OT) at 3T with the aim of visualizing axonal damage in multiple sclerosis (MS). Materials and Methods Imaging was performed on a 3T scanner employing a cu...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2005-08, Vol.22 (2), p.302-306 |
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| creator | Vinogradov, Elena Degenhardt, Alexandra Smith, Derek Marquis, Robert Vartanian, Timothy K. Kinkel, Philip Maier, Stephan E. Hackney, David B. Lenkinski, Robert E. |
| description | Purpose
To evaluate techniques for anatomical and physiological imaging of the intracranial optic nerve (ON), optic chiasm (OC), and optic tract (OT) at 3T with the aim of visualizing axonal damage in multiple sclerosis (MS).
Materials and Methods
Imaging was performed on a 3T scanner employing a custom‐designed head coil that consisted of a coil array with four coils (30 × 30 cm2). Oblique fast spin echo (FSE) images, magnetization transfer (MT)‐enhanced 3D gradient‐echo (GRE) time‐of‐flight (TOF) images, and line scan diffusion images (LSDI) were obtained. Full diffusion tensor (DT) analysis was performed, and apparent diffusion coefficient (ADC), fractional anisotropy (FA), and fiber direction maps were obtained.
Results
FSE anatomic images were obtained with an in‐plane resolution of 0.39 × 0.52 mm2. The in‐plane resolution of the MT and LSDI images was 0.78 × 0.78 mm2. The OC, intracranial ON, and OT can be seen on these images. The dominant fiber orientations in the OC, ON, and OT, as derived from the DT images, are displayed.
Conclusion
This study shows that by using 3T and a custom‐designed, four‐channel head coil, it is possible to acquire high‐resolution anatomical and physiological images of the OC, ON, and OT. The pilot results presented here pave the way for imaging the anterior visual pathway in patients with MS. J. Magn. Reson. Imaging 2005;22:302–306. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmri.20370 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68069499</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19415317</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4980-8bfe165079b657d4a188f9a7c10001425d33507773c96cf05db164fcaa1f922b3</originalsourceid><addsrcrecordid>eNqFkUtv1DAUhS0Eog_Y8AOQVyxQU_yI43iJRtAWtUUqhVlajmPPuCT21HZEC38epzOFHazu1TnfPdLVAeAVRscYIfLuZozumCDK0ROwjxkhFWFt87TsiNEKt4jvgYOUbhBCQtTsOdjDDSItqfk--HXqVusqmhSGKbvgofIqh9HpI9g7a6c0a9n4FOJR8Xo4qpU32f1UD3SOyidr4qOs4RzlldcGuqI5v4LBwrw2MGxmW6-dSiNUGdLrF-CZVUMyL3fzEHz9-OF6cVqdfz45W7w_r3QtWlS1nTW4YYiLrmG8rxVuWysU1-V5hGvCekqLyznVotEWsb7DTW21UtgKQjp6CN5sczcx3E4mZTm6pM0wKG_ClGTTokbUQvwXxKLGjGJewLdbUMeQUjRWbmJ5N95LjOTciZw7kQ-dFPj1LnXqRtP_RXclFABvgR9uMPf_iJKfLq7OHkOr7Y1L2dz9uVHxu2w45UwuL0_k4svF8nKx_Cav6G_-IKdM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19415317</pqid></control><display><type>article</type><title>High-resolution anatomic, diffusion tensor, and magnetization transfer magnetic resonance imaging of the optic chiasm at 3T</title><source>MEDLINE</source><source>Wiley Online Library Free Content</source><source>Access via Wiley Online Library</source><creator>Vinogradov, Elena ; Degenhardt, Alexandra ; Smith, Derek ; Marquis, Robert ; Vartanian, Timothy K. ; Kinkel, Philip ; Maier, Stephan E. ; Hackney, David B. ; Lenkinski, Robert E.</creator><creatorcontrib>Vinogradov, Elena ; Degenhardt, Alexandra ; Smith, Derek ; Marquis, Robert ; Vartanian, Timothy K. ; Kinkel, Philip ; Maier, Stephan E. ; Hackney, David B. ; Lenkinski, Robert E.</creatorcontrib><description>Purpose
To evaluate techniques for anatomical and physiological imaging of the intracranial optic nerve (ON), optic chiasm (OC), and optic tract (OT) at 3T with the aim of visualizing axonal damage in multiple sclerosis (MS).
Materials and Methods
Imaging was performed on a 3T scanner employing a custom‐designed head coil that consisted of a coil array with four coils (30 × 30 cm2). Oblique fast spin echo (FSE) images, magnetization transfer (MT)‐enhanced 3D gradient‐echo (GRE) time‐of‐flight (TOF) images, and line scan diffusion images (LSDI) were obtained. Full diffusion tensor (DT) analysis was performed, and apparent diffusion coefficient (ADC), fractional anisotropy (FA), and fiber direction maps were obtained.
Results
FSE anatomic images were obtained with an in‐plane resolution of 0.39 × 0.52 mm2. The in‐plane resolution of the MT and LSDI images was 0.78 × 0.78 mm2. The OC, intracranial ON, and OT can be seen on these images. The dominant fiber orientations in the OC, ON, and OT, as derived from the DT images, are displayed.
Conclusion
This study shows that by using 3T and a custom‐designed, four‐channel head coil, it is possible to acquire high‐resolution anatomical and physiological images of the OC, ON, and OT. The pilot results presented here pave the way for imaging the anterior visual pathway in patients with MS. J. Magn. Reson. Imaging 2005;22:302–306. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.20370</identifier><identifier>PMID: 16028247</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Case-Control Studies ; Cranial Nerve Diseases - diagnosis ; Cranial Nerve Diseases - etiology ; Diffusion Magnetic Resonance Imaging - methods ; Female ; Humans ; Image Processing, Computer-Assisted ; line scan diffusion imaging ; magnetization transfer ; Male ; Middle Aged ; multicoil ; Multiple Sclerosis - complications ; Multiple Sclerosis - diagnosis ; Optic Chiasm - anatomy & histology ; Optic Chiasm - pathology ; optic nerve ; Optic Nerve - anatomy & histology ; Optic Nerve - pathology ; Pilot Projects ; Reference Values ; Risk Assessment ; Sensitivity and Specificity</subject><ispartof>Journal of magnetic resonance imaging, 2005-08, Vol.22 (2), p.302-306</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><rights>(c) 2005 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4980-8bfe165079b657d4a188f9a7c10001425d33507773c96cf05db164fcaa1f922b3</citedby><cites>FETCH-LOGICAL-c4980-8bfe165079b657d4a188f9a7c10001425d33507773c96cf05db164fcaa1f922b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.20370$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.20370$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16028247$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vinogradov, Elena</creatorcontrib><creatorcontrib>Degenhardt, Alexandra</creatorcontrib><creatorcontrib>Smith, Derek</creatorcontrib><creatorcontrib>Marquis, Robert</creatorcontrib><creatorcontrib>Vartanian, Timothy K.</creatorcontrib><creatorcontrib>Kinkel, Philip</creatorcontrib><creatorcontrib>Maier, Stephan E.</creatorcontrib><creatorcontrib>Hackney, David B.</creatorcontrib><creatorcontrib>Lenkinski, Robert E.</creatorcontrib><title>High-resolution anatomic, diffusion tensor, and magnetization transfer magnetic resonance imaging of the optic chiasm at 3T</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To evaluate techniques for anatomical and physiological imaging of the intracranial optic nerve (ON), optic chiasm (OC), and optic tract (OT) at 3T with the aim of visualizing axonal damage in multiple sclerosis (MS).
Materials and Methods
Imaging was performed on a 3T scanner employing a custom‐designed head coil that consisted of a coil array with four coils (30 × 30 cm2). Oblique fast spin echo (FSE) images, magnetization transfer (MT)‐enhanced 3D gradient‐echo (GRE) time‐of‐flight (TOF) images, and line scan diffusion images (LSDI) were obtained. Full diffusion tensor (DT) analysis was performed, and apparent diffusion coefficient (ADC), fractional anisotropy (FA), and fiber direction maps were obtained.
Results
FSE anatomic images were obtained with an in‐plane resolution of 0.39 × 0.52 mm2. The in‐plane resolution of the MT and LSDI images was 0.78 × 0.78 mm2. The OC, intracranial ON, and OT can be seen on these images. The dominant fiber orientations in the OC, ON, and OT, as derived from the DT images, are displayed.
Conclusion
This study shows that by using 3T and a custom‐designed, four‐channel head coil, it is possible to acquire high‐resolution anatomical and physiological images of the OC, ON, and OT. The pilot results presented here pave the way for imaging the anterior visual pathway in patients with MS. J. Magn. Reson. Imaging 2005;22:302–306. © 2005 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Cranial Nerve Diseases - diagnosis</subject><subject>Cranial Nerve Diseases - etiology</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>line scan diffusion imaging</subject><subject>magnetization transfer</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multicoil</subject><subject>Multiple Sclerosis - complications</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Optic Chiasm - anatomy & histology</subject><subject>Optic Chiasm - pathology</subject><subject>optic nerve</subject><subject>Optic Nerve - anatomy & histology</subject><subject>Optic Nerve - pathology</subject><subject>Pilot Projects</subject><subject>Reference Values</subject><subject>Risk Assessment</subject><subject>Sensitivity and Specificity</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS0Eog_Y8AOQVyxQU_yI43iJRtAWtUUqhVlajmPPuCT21HZEC38epzOFHazu1TnfPdLVAeAVRscYIfLuZozumCDK0ROwjxkhFWFt87TsiNEKt4jvgYOUbhBCQtTsOdjDDSItqfk--HXqVusqmhSGKbvgofIqh9HpI9g7a6c0a9n4FOJR8Xo4qpU32f1UD3SOyidr4qOs4RzlldcGuqI5v4LBwrw2MGxmW6-dSiNUGdLrF-CZVUMyL3fzEHz9-OF6cVqdfz45W7w_r3QtWlS1nTW4YYiLrmG8rxVuWysU1-V5hGvCekqLyznVotEWsb7DTW21UtgKQjp6CN5sczcx3E4mZTm6pM0wKG_ClGTTokbUQvwXxKLGjGJewLdbUMeQUjRWbmJ5N95LjOTciZw7kQ-dFPj1LnXqRtP_RXclFABvgR9uMPf_iJKfLq7OHkOr7Y1L2dz9uVHxu2w45UwuL0_k4svF8nKx_Cav6G_-IKdM</recordid><startdate>200508</startdate><enddate>200508</enddate><creator>Vinogradov, Elena</creator><creator>Degenhardt, Alexandra</creator><creator>Smith, Derek</creator><creator>Marquis, Robert</creator><creator>Vartanian, Timothy K.</creator><creator>Kinkel, Philip</creator><creator>Maier, Stephan E.</creator><creator>Hackney, David B.</creator><creator>Lenkinski, Robert E.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200508</creationdate><title>High-resolution anatomic, diffusion tensor, and magnetization transfer magnetic resonance imaging of the optic chiasm at 3T</title><author>Vinogradov, Elena ; Degenhardt, Alexandra ; Smith, Derek ; Marquis, Robert ; Vartanian, Timothy K. ; Kinkel, Philip ; Maier, Stephan E. ; Hackney, David B. ; Lenkinski, Robert E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4980-8bfe165079b657d4a188f9a7c10001425d33507773c96cf05db164fcaa1f922b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Cranial Nerve Diseases - diagnosis</topic><topic>Cranial Nerve Diseases - etiology</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>line scan diffusion imaging</topic><topic>magnetization transfer</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multicoil</topic><topic>Multiple Sclerosis - complications</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Optic Chiasm - anatomy & histology</topic><topic>Optic Chiasm - pathology</topic><topic>optic nerve</topic><topic>Optic Nerve - anatomy & histology</topic><topic>Optic Nerve - pathology</topic><topic>Pilot Projects</topic><topic>Reference Values</topic><topic>Risk Assessment</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vinogradov, Elena</creatorcontrib><creatorcontrib>Degenhardt, Alexandra</creatorcontrib><creatorcontrib>Smith, Derek</creatorcontrib><creatorcontrib>Marquis, Robert</creatorcontrib><creatorcontrib>Vartanian, Timothy K.</creatorcontrib><creatorcontrib>Kinkel, Philip</creatorcontrib><creatorcontrib>Maier, Stephan E.</creatorcontrib><creatorcontrib>Hackney, David B.</creatorcontrib><creatorcontrib>Lenkinski, Robert E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vinogradov, Elena</au><au>Degenhardt, Alexandra</au><au>Smith, Derek</au><au>Marquis, Robert</au><au>Vartanian, Timothy K.</au><au>Kinkel, Philip</au><au>Maier, Stephan E.</au><au>Hackney, David B.</au><au>Lenkinski, Robert E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-resolution anatomic, diffusion tensor, and magnetization transfer magnetic resonance imaging of the optic chiasm at 3T</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2005-08</date><risdate>2005</risdate><volume>22</volume><issue>2</issue><spage>302</spage><epage>306</epage><pages>302-306</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To evaluate techniques for anatomical and physiological imaging of the intracranial optic nerve (ON), optic chiasm (OC), and optic tract (OT) at 3T with the aim of visualizing axonal damage in multiple sclerosis (MS).
Materials and Methods
Imaging was performed on a 3T scanner employing a custom‐designed head coil that consisted of a coil array with four coils (30 × 30 cm2). Oblique fast spin echo (FSE) images, magnetization transfer (MT)‐enhanced 3D gradient‐echo (GRE) time‐of‐flight (TOF) images, and line scan diffusion images (LSDI) were obtained. Full diffusion tensor (DT) analysis was performed, and apparent diffusion coefficient (ADC), fractional anisotropy (FA), and fiber direction maps were obtained.
Results
FSE anatomic images were obtained with an in‐plane resolution of 0.39 × 0.52 mm2. The in‐plane resolution of the MT and LSDI images was 0.78 × 0.78 mm2. The OC, intracranial ON, and OT can be seen on these images. The dominant fiber orientations in the OC, ON, and OT, as derived from the DT images, are displayed.
Conclusion
This study shows that by using 3T and a custom‐designed, four‐channel head coil, it is possible to acquire high‐resolution anatomical and physiological images of the OC, ON, and OT. The pilot results presented here pave the way for imaging the anterior visual pathway in patients with MS. J. Magn. Reson. Imaging 2005;22:302–306. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16028247</pmid><doi>10.1002/jmri.20370</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Case-Control Studies Cranial Nerve Diseases - diagnosis Cranial Nerve Diseases - etiology Diffusion Magnetic Resonance Imaging - methods Female Humans Image Processing, Computer-Assisted line scan diffusion imaging magnetization transfer Male Middle Aged multicoil Multiple Sclerosis - complications Multiple Sclerosis - diagnosis Optic Chiasm - anatomy & histology Optic Chiasm - pathology optic nerve Optic Nerve - anatomy & histology Optic Nerve - pathology Pilot Projects Reference Values Risk Assessment Sensitivity and Specificity |
| title | High-resolution anatomic, diffusion tensor, and magnetization transfer magnetic resonance imaging of the optic chiasm at 3T |
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