A DNA-Binding Copper(I) Metallosupramolecular Cylinder that Acts as an Artificial Nuclease
The DNA binding of a dicationic pyridylimine‐based dicopper(I) metallosupramolecular cylinder is reported together with its ability to act as an artificial nuclease. The cylinder binds strongly to DNA; more strongly than the spherical dication [Ru(phen)3]2+ (phen=1,10‐phenanthroline), but more weakl...
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| Veröffentlicht in: | Chemistry : a European journal 2006-06, Vol.12 (18), p.4919-4927 |
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| creator | Childs, Laura J. Malina, Jaroslav Rolfsnes, Britt Elin Pascu, Mirela Prieto, Maria J. Broome, Mark J. Rodger, P. Mark Sletten, Einar Moreno, Virtudes Rodger, Alison Hannon, Michael J. |
| description | The DNA binding of a dicationic pyridylimine‐based dicopper(I) metallosupramolecular cylinder is reported together with its ability to act as an artificial nuclease. The cylinder binds strongly to DNA; more strongly than the spherical dication [Ru(phen)3]2+ (phen=1,10‐phenanthroline), but more weakly than the corresponding tetracationic cylinders. DNA coiling effects are not observed with this dication, in contrast to the situation with the previously reported tetracationic cylinder involving a similar ligand. Linear dichroism (LD) data suggests that the dicopper cylinder binds in a different orientation from that of the tetracationic iron cylinder. Furthermore, the dicopper cylinder shows DNA‐cleavage activity in the presence of peroxide. Of particular note is that the cylinder displays a marked and unusual ability to cleave both DNA strands at the same site, probably reflecting its dinuclear nature and possibly its mode of binding to the DNA.
It's a snip! Dicationic pyridylimine‐based dicopper(I) metallosupramolecular cylinders bind strongly to DNA and exhibit cleavage activity towards double‐stranded DNA in the presence of peroxide (see illustration). |
| doi_str_mv | 10.1002/chem.200600060 |
| format | Article |
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It's a snip! Dicationic pyridylimine‐based dicopper(I) metallosupramolecular cylinders bind strongly to DNA and exhibit cleavage activity towards double‐stranded DNA in the presence of peroxide (see illustration).</description><identifier>ISSN: 0947-6539</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.200600060</identifier><identifier>PMID: 16642530</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>artificial nucleases ; bioinorganic chemistry ; copper ; Copper - chemistry ; Deoxyribonucleases - chemistry ; DNA - chemistry ; DNA Cleavage ; Organometallic Compounds - chemistry ; Pyridines - chemistry ; supramolecular chemistry</subject><ispartof>Chemistry : a European journal, 2006-06, Vol.12 (18), p.4919-4927</ispartof><rights>Copyright © 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4120-28ba875c49edc29fdea5db6927ab4655b1e25f7fc51afa9a59b9a942152dc4e43</citedby><cites>FETCH-LOGICAL-c4120-28ba875c49edc29fdea5db6927ab4655b1e25f7fc51afa9a59b9a942152dc4e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fchem.200600060$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fchem.200600060$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16642530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Childs, Laura J.</creatorcontrib><creatorcontrib>Malina, Jaroslav</creatorcontrib><creatorcontrib>Rolfsnes, Britt Elin</creatorcontrib><creatorcontrib>Pascu, Mirela</creatorcontrib><creatorcontrib>Prieto, Maria J.</creatorcontrib><creatorcontrib>Broome, Mark J.</creatorcontrib><creatorcontrib>Rodger, P. Mark</creatorcontrib><creatorcontrib>Sletten, Einar</creatorcontrib><creatorcontrib>Moreno, Virtudes</creatorcontrib><creatorcontrib>Rodger, Alison</creatorcontrib><creatorcontrib>Hannon, Michael J.</creatorcontrib><title>A DNA-Binding Copper(I) Metallosupramolecular Cylinder that Acts as an Artificial Nuclease</title><title>Chemistry : a European journal</title><addtitle>Chemistry - A European Journal</addtitle><description>The DNA binding of a dicationic pyridylimine‐based dicopper(I) metallosupramolecular cylinder is reported together with its ability to act as an artificial nuclease. The cylinder binds strongly to DNA; more strongly than the spherical dication [Ru(phen)3]2+ (phen=1,10‐phenanthroline), but more weakly than the corresponding tetracationic cylinders. DNA coiling effects are not observed with this dication, in contrast to the situation with the previously reported tetracationic cylinder involving a similar ligand. Linear dichroism (LD) data suggests that the dicopper cylinder binds in a different orientation from that of the tetracationic iron cylinder. Furthermore, the dicopper cylinder shows DNA‐cleavage activity in the presence of peroxide. Of particular note is that the cylinder displays a marked and unusual ability to cleave both DNA strands at the same site, probably reflecting its dinuclear nature and possibly its mode of binding to the DNA.
It's a snip! Dicationic pyridylimine‐based dicopper(I) metallosupramolecular cylinders bind strongly to DNA and exhibit cleavage activity towards double‐stranded DNA in the presence of peroxide (see illustration).</description><subject>artificial nucleases</subject><subject>bioinorganic chemistry</subject><subject>copper</subject><subject>Copper - chemistry</subject><subject>Deoxyribonucleases - chemistry</subject><subject>DNA - chemistry</subject><subject>DNA Cleavage</subject><subject>Organometallic Compounds - chemistry</subject><subject>Pyridines - chemistry</subject><subject>supramolecular chemistry</subject><issn>0947-6539</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1ERbeFK0fkE6KHLP6InfgY0k-pXYQoH-JiTZwJDTib1E4E---b1a4Kt0ozmsvzvtI8hLzmbMkZE-_dHXZLwZhm231GFlwJnshMq-dkwUyaJVpJc0iOYvw1I0ZL-YIccq1ToSRbkB8FPV0VyYd2Xbfrn7TshwHDu6sTeoMjeN_HaQjQ9R7d5CHQcuNnEgMd72CkhRsjhXnWtAhj27SuBU9Xk_MIEV-SgwZ8xFf7e0y-nJ_dlpfJ9ceLq7K4TlzKBUtEXkGeKZcarJ0wTY2g6kobkUGVaqUqjkI1WeMUhwYMKFMZMKmYH61diqk8Jm93vUPo7yeMo-3a6NB7WGM_RatzpvPZxJOg4JIzafgMLnegC32MARs7hLaDsLGc2a12u9VuH7XPgTf75qnqsP6H7z3PgNkBf1qPmyfqbHl5dvN_ebLLtnHEv49ZCL-tzmSm7LfVhb3N8q_fP8nP9lQ-ANH1nVs</recordid><startdate>20060614</startdate><enddate>20060614</enddate><creator>Childs, Laura J.</creator><creator>Malina, Jaroslav</creator><creator>Rolfsnes, Britt Elin</creator><creator>Pascu, Mirela</creator><creator>Prieto, Maria J.</creator><creator>Broome, Mark J.</creator><creator>Rodger, P. Mark</creator><creator>Sletten, Einar</creator><creator>Moreno, Virtudes</creator><creator>Rodger, Alison</creator><creator>Hannon, Michael J.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20060614</creationdate><title>A DNA-Binding Copper(I) Metallosupramolecular Cylinder that Acts as an Artificial Nuclease</title><author>Childs, Laura J. ; Malina, Jaroslav ; Rolfsnes, Britt Elin ; Pascu, Mirela ; Prieto, Maria J. ; Broome, Mark J. ; Rodger, P. Mark ; Sletten, Einar ; Moreno, Virtudes ; Rodger, Alison ; Hannon, Michael J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4120-28ba875c49edc29fdea5db6927ab4655b1e25f7fc51afa9a59b9a942152dc4e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>artificial nucleases</topic><topic>bioinorganic chemistry</topic><topic>copper</topic><topic>Copper - chemistry</topic><topic>Deoxyribonucleases - chemistry</topic><topic>DNA - chemistry</topic><topic>DNA Cleavage</topic><topic>Organometallic Compounds - chemistry</topic><topic>Pyridines - chemistry</topic><topic>supramolecular chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Childs, Laura J.</creatorcontrib><creatorcontrib>Malina, Jaroslav</creatorcontrib><creatorcontrib>Rolfsnes, Britt Elin</creatorcontrib><creatorcontrib>Pascu, Mirela</creatorcontrib><creatorcontrib>Prieto, Maria J.</creatorcontrib><creatorcontrib>Broome, Mark J.</creatorcontrib><creatorcontrib>Rodger, P. Mark</creatorcontrib><creatorcontrib>Sletten, Einar</creatorcontrib><creatorcontrib>Moreno, Virtudes</creatorcontrib><creatorcontrib>Rodger, Alison</creatorcontrib><creatorcontrib>Hannon, Michael J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry : a European journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Childs, Laura J.</au><au>Malina, Jaroslav</au><au>Rolfsnes, Britt Elin</au><au>Pascu, Mirela</au><au>Prieto, Maria J.</au><au>Broome, Mark J.</au><au>Rodger, P. Mark</au><au>Sletten, Einar</au><au>Moreno, Virtudes</au><au>Rodger, Alison</au><au>Hannon, Michael J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A DNA-Binding Copper(I) Metallosupramolecular Cylinder that Acts as an Artificial Nuclease</atitle><jtitle>Chemistry : a European journal</jtitle><addtitle>Chemistry - A European Journal</addtitle><date>2006-06-14</date><risdate>2006</risdate><volume>12</volume><issue>18</issue><spage>4919</spage><epage>4927</epage><pages>4919-4927</pages><issn>0947-6539</issn><eissn>1521-3765</eissn><abstract>The DNA binding of a dicationic pyridylimine‐based dicopper(I) metallosupramolecular cylinder is reported together with its ability to act as an artificial nuclease. The cylinder binds strongly to DNA; more strongly than the spherical dication [Ru(phen)3]2+ (phen=1,10‐phenanthroline), but more weakly than the corresponding tetracationic cylinders. DNA coiling effects are not observed with this dication, in contrast to the situation with the previously reported tetracationic cylinder involving a similar ligand. Linear dichroism (LD) data suggests that the dicopper cylinder binds in a different orientation from that of the tetracationic iron cylinder. Furthermore, the dicopper cylinder shows DNA‐cleavage activity in the presence of peroxide. Of particular note is that the cylinder displays a marked and unusual ability to cleave both DNA strands at the same site, probably reflecting its dinuclear nature and possibly its mode of binding to the DNA.
It's a snip! Dicationic pyridylimine‐based dicopper(I) metallosupramolecular cylinders bind strongly to DNA and exhibit cleavage activity towards double‐stranded DNA in the presence of peroxide (see illustration).</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>16642530</pmid><doi>10.1002/chem.200600060</doi><tpages>9</tpages></addata></record> |
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| subjects | artificial nucleases bioinorganic chemistry copper Copper - chemistry Deoxyribonucleases - chemistry DNA - chemistry DNA Cleavage Organometallic Compounds - chemistry Pyridines - chemistry supramolecular chemistry |
| title | A DNA-Binding Copper(I) Metallosupramolecular Cylinder that Acts as an Artificial Nuclease |
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