Cell-compatible covalently reinforced beads obtained from a chemoenzymatically engineered alginate

A chemoenzymatic strategy has been exploited to make covalently linked alginate beads with high stability. This was achieved by grafting mannuronan (alginate with 100% mannuronic acid (M)) with methacrylate moieties and then performing two enzymatic steps converting M to guluronic acid (G) in altern...

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Veröffentlicht in:	Biomaterials 2006-09, Vol.27 (27), p.4726-4737
Hauptverfasser:	Rokstad, Anne Mari, Donati, Ivan, Borgogna, Massimiliano, Oberholzer, Josè, Strand, Berit Løkensgard, Espevik, Terje, Skjåk-Bræk, Gudmund
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginate beads Alginates - chemistry Animals Biocompatible Materials - chemistry Bioreactors Cell Culture Techniques - methods Cell Line Cell Survival Cell Transplantation - methods Cell viability Chemical Engineering - methods Chemoenzymatic engineering Cross-Linking Reagents - chemistry Drug Delivery Systems Enzymes - chemistry Humans Insulin - metabolism Insulin Secretion Islets Islets of Langerhans - cytology Islets of Langerhans - physiology Materials Testing Mice Microspheres Myoblasts - cytology Myoblasts - physiology Photocross-linking Stability Tissue Engineering
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