The cell-mediated immune response induced by plasmid encoding bovine herpesvirus 1 glycoprotein B is enhanced by plasmid encoding IL-12 when delivered intramuscularly or by gene gun, but not after intradermal injection

Bovine herpesvirus 1 (BHV-1) causes respiratory and genital infections in cattle. Previously we demonstrated that a DNA vaccine encoding a truncated, secreted form of BHV-1 glycoprotein B (tgB) induces cytotoxic T lymphocyte (CTL) responses in C3H mice. In this study we investigated the potential of...

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Veröffentlicht in:	Vaccine 2006-06, Vol.24 (25), p.5349-5359
Hauptverfasser:	Huang, Y., Babiuk, L.A., van Drunen Littel-van den Hurk, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - blood Applied microbiology Biolistics Biological and medical sciences Bovine herpesvirus 1 Cattle Cercopithecus aethiops COS Cells Cytotoxic T cell response DNA vaccine Fundamental and applied biological sciences. Psychology Genes Glycoprotein B Herpesvirus 1, Bovine - genetics Herpesvirus 1, Bovine - immunology Herpesvirus Vaccines - administration & dosage Herpesvirus Vaccines - genetics Herpesvirus Vaccines - immunology Humans IL-12 Immune response Immune system Immunization Injections, Intradermal Injections, Intramuscular Interleukin-12 - genetics Interleukin-12 - immunology Lymph nodes Lymphocytes Medical research Mice Mice, Inbred C3H Microbiology Miscellaneous Plasmids Plasmids - administration & dosage Plasmids - genetics T-Lymphocytes, Cytotoxic - immunology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - administration & dosage Vaccines, DNA - immunology Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral Proteins Virology
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