Adult cystic fibrosis presenting with recurrent non-tuberculous mycobacterial infections
Some of this increase is related to the high rate of disseminated M avium complex disease in patients with AIDS; however, there could also have been an increase in the rate of NTM infections in other groups of patients, such as those with CF.2,3 The classic description of NTM pulmonary infection is...
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| Veröffentlicht in: | The Lancet (British edition) 2006-06, Vol.367 (9526), p.1952-1952 |
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| creator | Chbeir, Elie Casas, Luis Toubia, Nagib Tawk, Maroun Brown, Brent |
| description | Some of this increase is related to the high rate of disseminated M avium complex disease in patients with AIDS; however, there could also have been an increase in the rate of NTM infections in other groups of patients, such as those with CF.2,3 The classic description of NTM pulmonary infection is that of a patient with cavitary infiltrates and underlying lung disease. Among adults with CF, 63% are aged 18-29 years, 25% 30-39 years, 10% 40-49 years, and 2% over 50 years ; adults will represent >40% of the US cystic fibrosis population in 2005.4 Among the 22 301 patients in the 2000 CF Foundation registry, the diagnosis was established after the age of 17 years in only 831 (3.7%); sweat chloride tests were abnormal in 90% of cases.4 Although NTM infections in CF are well described, recurrent NTM infection as the initial presentation of CF has not been described. |
| doi_str_mv | 10.1016/S0140-6736(06)68851-X |
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Among adults with CF, 63% are aged 18-29 years, 25% 30-39 years, 10% 40-49 years, and 2% over 50 years ; adults will represent >40% of the US cystic fibrosis population in 2005.4 Among the 22 301 patients in the 2000 CF Foundation registry, the diagnosis was established after the age of 17 years in only 831 (3.7%); sweat chloride tests were abnormal in 90% of cases.4 Although NTM infections in CF are well described, recurrent NTM infection as the initial presentation of CF has not been described.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(06)68851-X</identifier><identifier>PMID: 16765765</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Anti-Bacterial Agents - therapeutic use ; Bacterial diseases ; Biological and medical sciences ; Cystic fibrosis ; Cystic Fibrosis - diagnosis ; Cystic Fibrosis - drug therapy ; Cystic Fibrosis - genetics ; Diagnostic Errors ; Errors of metabolism ; General aspects ; Human bacterial diseases ; Humans ; Infections ; Infectious diseases ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Miscellaneous hereditary metabolic disorders ; Mycobacterium avium Complex - isolation & purification ; Mycobacterium chelonae - isolation & purification ; Patients ; Tuberculosis - diagnosis ; Tuberculosis and atypical mycobacterial infections</subject><ispartof>The Lancet (British edition), 2006-06, Vol.367 (9526), p.1952-1952</ispartof><rights>2006 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Lancet Ltd. 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Among adults with CF, 63% are aged 18-29 years, 25% 30-39 years, 10% 40-49 years, and 2% over 50 years ; adults will represent >40% of the US cystic fibrosis population in 2005.4 Among the 22 301 patients in the 2000 CF Foundation registry, the diagnosis was established after the age of 17 years in only 831 (3.7%); sweat chloride tests were abnormal in 90% of cases.4 Although NTM infections in CF are well described, recurrent NTM infection as the initial presentation of CF has not been described.</description><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - diagnosis</subject><subject>Cystic Fibrosis - drug therapy</subject><subject>Cystic Fibrosis - genetics</subject><subject>Diagnostic Errors</subject><subject>Errors of metabolism</subject><subject>General aspects</subject><subject>Human bacterial 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chbeir, Elie</au><au>Casas, Luis</au><au>Toubia, Nagib</au><au>Tawk, Maroun</au><au>Brown, Brent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adult cystic fibrosis presenting with recurrent non-tuberculous mycobacterial infections</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>2006-06-10</date><risdate>2006</risdate><volume>367</volume><issue>9526</issue><spage>1952</spage><epage>1952</epage><pages>1952-1952</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Some of this increase is related to the high rate of disseminated M avium complex disease in patients with AIDS; however, there could also have been an increase in the rate of NTM infections in other groups of patients, such as those with CF.2,3 The classic description of NTM pulmonary infection is that of a patient with cavitary infiltrates and underlying lung disease. Among adults with CF, 63% are aged 18-29 years, 25% 30-39 years, 10% 40-49 years, and 2% over 50 years ; adults will represent >40% of the US cystic fibrosis population in 2005.4 Among the 22 301 patients in the 2000 CF Foundation registry, the diagnosis was established after the age of 17 years in only 831 (3.7%); sweat chloride tests were abnormal in 90% of cases.4 Although NTM infections in CF are well described, recurrent NTM infection as the initial presentation of CF has not been described.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>16765765</pmid><doi>10.1016/S0140-6736(06)68851-X</doi><tpages>1</tpages></addata></record> |
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| subjects | Anti-Bacterial Agents - therapeutic use Bacterial diseases Biological and medical sciences Cystic fibrosis Cystic Fibrosis - diagnosis Cystic Fibrosis - drug therapy Cystic Fibrosis - genetics Diagnostic Errors Errors of metabolism General aspects Human bacterial diseases Humans Infections Infectious diseases Male Medical sciences Metabolic diseases Middle Aged Miscellaneous hereditary metabolic disorders Mycobacterium avium Complex - isolation & purification Mycobacterium chelonae - isolation & purification Patients Tuberculosis - diagnosis Tuberculosis and atypical mycobacterial infections |
| title | Adult cystic fibrosis presenting with recurrent non-tuberculous mycobacterial infections |
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