Synthesis and antibacterial activity of alkyl derivatives of the glycopeptide antibiotic A40926 and their amides

Lipophilic alkylated derivatives of A40926 containing basic amides showed a strong increase in antibiotic activity. New derivatives of the glycopeptide antibiotic A40926 were synthesized and evaluated for antimicrobial activity against VRE. Deacylated A40926 was obtained by microbial transformation...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-08, Vol.15 (16), p.3801-3805
Hauptverfasser:	Maffioli, Sonia I., Ciabatti, Romeo, Romanò, Gabriella, Marzorati, Ettore, Preobrazhenskaya, Maria, Pavlov, Andrej
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - chemistry Amides - pharmacology Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotic Enterococcus - drug effects Glycopeptides Glycopeptides - chemistry Microbial Sensitivity Tests Molecular Conformation Structure-Activity Relationship Teicoplanin - analogs & derivatives Teicoplanin - chemical synthesis Teicoplanin - chemistry Teicoplanin - pharmacology Vancomycin Resistance VRE
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