Oral plasmablastic lymphoma in an HIV-negative patient: A case report and review of the literature
Plasmablastic lymphoma is an HIV-associated non-Hodgkin's lymphoma that primarily affects the oral cavity and jaws. The purpose of this report is to describe the first case of plasmablastic lymphoma occurring in an HIV-negative, nonimmunocompromised individual, and to review the histopathologic...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2005-08, Vol.100 (2), p.198-206 |
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| container_title | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics |
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| creator | Scheper, Mark A. Nikitakis, Nikolaos G. Fernandes, Rui Gocke, Christopher D. Ord, Robert A. Sauk, John J. |
| description | Plasmablastic lymphoma is an HIV-associated non-Hodgkin's lymphoma that primarily affects the oral cavity and jaws. The purpose of this report is to describe the first case of plasmablastic lymphoma occurring in an HIV-negative, nonimmunocompromised individual, and to review the histopathologic and immunohistochemical phenotype of this lymphoma. Histopathologically, our case exhibited a dense, diffuse lymphocytic infiltrate of noncohesive large lymphocytes with plasmacytoid features. Immunohistochemical analysis revealed positivity for the B-cell marker CD79a, VS38c, Epstein-Barr virus latent membrane protein (LMP), immunoglobulin G (IgG), and lambda light chain restriction. Neoplastic cells were negative for leukocyte common antigen, CD20, CD3, CD10, CD138, Bcl-2, Bcl-6, desmin, actin, EMA, S-100, HMB45, Alk-1, HHV8, IgA, IgM, and cytokeratin. The features of this rare disease are summarized based on a comprehensive review of the epidemiologic, clinical and immunohistochemical findings of previously reported cases. |
| doi_str_mv | 10.1016/j.tripleo.2004.11.050 |
| format | Article |
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The purpose of this report is to describe the first case of plasmablastic lymphoma occurring in an HIV-negative, nonimmunocompromised individual, and to review the histopathologic and immunohistochemical phenotype of this lymphoma. Histopathologically, our case exhibited a dense, diffuse lymphocytic infiltrate of noncohesive large lymphocytes with plasmacytoid features. Immunohistochemical analysis revealed positivity for the B-cell marker CD79a, VS38c, Epstein-Barr virus latent membrane protein (LMP), immunoglobulin G (IgG), and lambda light chain restriction. Neoplastic cells were negative for leukocyte common antigen, CD20, CD3, CD10, CD138, Bcl-2, Bcl-6, desmin, actin, EMA, S-100, HMB45, Alk-1, HHV8, IgA, IgM, and cytokeratin. The features of this rare disease are summarized based on a comprehensive review of the epidemiologic, clinical and immunohistochemical findings of previously reported cases.</description><identifier>ISSN: 1079-2104</identifier><identifier>EISSN: 1528-395X</identifier><identifier>DOI: 10.1016/j.tripleo.2004.11.050</identifier><identifier>PMID: 16037778</identifier><language>eng</language><publisher>St. Louis, MO: Mosby, Inc</publisher><subject>Biological and medical sciences ; Dentistry ; Hematologic and hematopoietic diseases ; HIV Seronegativity ; Humans ; Immunoglobulin G - analysis ; Immunoglobulin lambda-Chains - analysis ; Immunohistochemistry ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, B-Cell - pathology ; Lymphoma, Large B-Cell, Diffuse - pathology ; Male ; Mandibular Neoplasms - pathology ; Medical sciences ; Middle Aged ; Otorhinolaryngology. 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The purpose of this report is to describe the first case of plasmablastic lymphoma occurring in an HIV-negative, nonimmunocompromised individual, and to review the histopathologic and immunohistochemical phenotype of this lymphoma. Histopathologically, our case exhibited a dense, diffuse lymphocytic infiltrate of noncohesive large lymphocytes with plasmacytoid features. Immunohistochemical analysis revealed positivity for the B-cell marker CD79a, VS38c, Epstein-Barr virus latent membrane protein (LMP), immunoglobulin G (IgG), and lambda light chain restriction. Neoplastic cells were negative for leukocyte common antigen, CD20, CD3, CD10, CD138, Bcl-2, Bcl-6, desmin, actin, EMA, S-100, HMB45, Alk-1, HHV8, IgA, IgM, and cytokeratin. The features of this rare disease are summarized based on a comprehensive review of the epidemiologic, clinical and immunohistochemical findings of previously reported cases.</description><subject>Biological and medical sciences</subject><subject>Dentistry</subject><subject>Hematologic and hematopoietic diseases</subject><subject>HIV Seronegativity</subject><subject>Humans</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin lambda-Chains - analysis</subject><subject>Immunohistochemistry</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, B-Cell - pathology</subject><subject>Lymphoma, Large B-Cell, Diffuse - pathology</subject><subject>Male</subject><subject>Mandibular Neoplasms - pathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Plasma Cells</subject><subject>Viral Matrix Proteins - analysis</subject><issn>1079-2104</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP3DAQgK2qqFDKT6DypdyS2kn84oJWqC1ISFxoxc1y7Al45Txqe0H8-3q1kTj2MjOHb14fQueU1JRQ_n1b5-iXAHPdENLVlNaEkQ_ohLJGVq1ijx9LTYSqGkq6Y_Q5pS0hhLdKfULHlJNWCCFPUH8fTcBLMGk0fYnZWxzexuV5Hg32EzYTvrn9U03wZLJ_AbyUBFO-xBtsTQIcYZljLpgr5YuHVzwPOD8DDj5DNHkX4Qs6GkxIcLbmU_T754-H65vq7v7X7fXmrrIdU7myljVAmXDlOyd7AaaVLZeOuPKAHSTtW9EJ7jpHlRycEqyXqoGu5V2nrOvbU3RxmLvE-e8OUtajTxZCMBPMu6S5JJzxhhWQHUAb55QiDHqJfjTxTVOi93L1Vq9y9V6uplQXuaXv67pg14_g3rtWmwX4tgImWROGaCbr0zsnqGqU2nNXBw6KjiIt6mSLVQvOR7BZu9n_55R_5Uqa7g</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Scheper, Mark A.</creator><creator>Nikitakis, Nikolaos G.</creator><creator>Fernandes, Rui</creator><creator>Gocke, Christopher D.</creator><creator>Ord, Robert A.</creator><creator>Sauk, John J.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Oral plasmablastic lymphoma in an HIV-negative patient: A case report and review of the literature</title><author>Scheper, Mark A. ; Nikitakis, Nikolaos G. ; Fernandes, Rui ; Gocke, Christopher D. ; Ord, Robert A. ; Sauk, John J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-cc52e157d016d8b7ea38368d0d104cf81b37476d4d198fd975b892e436449cdb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Dentistry</topic><topic>Hematologic and hematopoietic diseases</topic><topic>HIV Seronegativity</topic><topic>Humans</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin lambda-Chains - analysis</topic><topic>Immunohistochemistry</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, B-Cell - pathology</topic><topic>Lymphoma, Large B-Cell, Diffuse - pathology</topic><topic>Male</topic><topic>Mandibular Neoplasms - pathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Plasma Cells</topic><topic>Viral Matrix Proteins - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scheper, Mark A.</creatorcontrib><creatorcontrib>Nikitakis, Nikolaos G.</creatorcontrib><creatorcontrib>Fernandes, Rui</creatorcontrib><creatorcontrib>Gocke, Christopher D.</creatorcontrib><creatorcontrib>Ord, Robert A.</creatorcontrib><creatorcontrib>Sauk, John J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scheper, Mark A.</au><au>Nikitakis, Nikolaos G.</au><au>Fernandes, Rui</au><au>Gocke, Christopher D.</au><au>Ord, Robert A.</au><au>Sauk, John J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral plasmablastic lymphoma in an HIV-negative patient: A case report and review of the literature</atitle><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>100</volume><issue>2</issue><spage>198</spage><epage>206</epage><pages>198-206</pages><issn>1079-2104</issn><eissn>1528-395X</eissn><abstract>Plasmablastic lymphoma is an HIV-associated non-Hodgkin's lymphoma that primarily affects the oral cavity and jaws. The purpose of this report is to describe the first case of plasmablastic lymphoma occurring in an HIV-negative, nonimmunocompromised individual, and to review the histopathologic and immunohistochemical phenotype of this lymphoma. Histopathologically, our case exhibited a dense, diffuse lymphocytic infiltrate of noncohesive large lymphocytes with plasmacytoid features. Immunohistochemical analysis revealed positivity for the B-cell marker CD79a, VS38c, Epstein-Barr virus latent membrane protein (LMP), immunoglobulin G (IgG), and lambda light chain restriction. Neoplastic cells were negative for leukocyte common antigen, CD20, CD3, CD10, CD138, Bcl-2, Bcl-6, desmin, actin, EMA, S-100, HMB45, Alk-1, HHV8, IgA, IgM, and cytokeratin. The features of this rare disease are summarized based on a comprehensive review of the epidemiologic, clinical and immunohistochemical findings of previously reported cases.</abstract><cop>St. Louis, MO</cop><pub>Mosby, Inc</pub><pmid>16037778</pmid><doi>10.1016/j.tripleo.2004.11.050</doi><tpages>9</tpages></addata></record> |
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| ispartof | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2005-08, Vol.100 (2), p.198-206 |
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| subjects | Biological and medical sciences Dentistry Hematologic and hematopoietic diseases HIV Seronegativity Humans Immunoglobulin G - analysis Immunoglobulin lambda-Chains - analysis Immunohistochemistry Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, B-Cell - pathology Lymphoma, Large B-Cell, Diffuse - pathology Male Mandibular Neoplasms - pathology Medical sciences Middle Aged Otorhinolaryngology. Stomatology Plasma Cells Viral Matrix Proteins - analysis |
| title | Oral plasmablastic lymphoma in an HIV-negative patient: A case report and review of the literature |
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