Silicone Versus Collagen Plugs for Treating Dry Eye: Results of a Prospective Randomized Trial Including Lacrimal Scintigraphy
To compare the short-term efficacy of collagen and silicone plugs for treating dry eye using quantitative lacrimal scintigraphy. Prospective randomized clinical trial. In this institutional study, 24 dry eye patients were evaluated in two groups: group I (n = 22 eyes) received collagen plugs and gro...
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| Veröffentlicht in: | American journal of ophthalmology 2005-07, Vol.140 (1), p.88.e1-88.e7 |
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| container_title | American journal of ophthalmology |
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| creator | Altan-Yaycioglu, Rana Gencoglu, E. Arzu Akova, Yonca Aydin Dursun, Dilek Cengiz, Fethi Akman, Ahmet |
| description | To compare the short-term efficacy of collagen and silicone plugs for treating dry eye using quantitative lacrimal scintigraphy.
Prospective randomized clinical trial.
In this institutional study, 24 dry eye patients were evaluated in two groups: group I (n = 22 eyes) received collagen plugs and group II (n = 26 eyes) received silicone plugs. Comparisons were made with normal control subjects (n = 22 eyes). Data for the Schirmer I test, tear break-up time, and ocular surface staining with rose bengal dye were recorded before and after punctal occlusion. Lacrimal scintigraphy was performed at each time point, and the time to half maximum activity on the ocular surface (T
1/2), and the percentage retention of activity on the ocular surface at the end of the dynamic study (RI) were recorded.
In both patient groups, Schirmer I results, tear break-up times, and rose bengal staining scores improved significantly after plug insertion. Mean T
1/2 values and RI values increased significantly in both groups (
P < .0001 for both). The differences for these values between groups I and II was statistically insignificant (
P > .05).
Collagen and silicone plugs both resulted in significant increases in aqueous tear volume, half-life of nuclear material on the ocular surface, and percentage of nuclear material retention. The groups’ post-insertion values for all parameters were similar. These results suggest that these two plug types have similar efficacy as treatments for dry eye in the short term. Further studies evaluating long-term results are required. |
| doi_str_mv | 10.1016/j.ajo.2005.02.031 |
| format | Article |
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Prospective randomized clinical trial.
In this institutional study, 24 dry eye patients were evaluated in two groups: group I (n = 22 eyes) received collagen plugs and group II (n = 26 eyes) received silicone plugs. Comparisons were made with normal control subjects (n = 22 eyes). Data for the Schirmer I test, tear break-up time, and ocular surface staining with rose bengal dye were recorded before and after punctal occlusion. Lacrimal scintigraphy was performed at each time point, and the time to half maximum activity on the ocular surface (T
1/2), and the percentage retention of activity on the ocular surface at the end of the dynamic study (RI) were recorded.
In both patient groups, Schirmer I results, tear break-up times, and rose bengal staining scores improved significantly after plug insertion. Mean T
1/2 values and RI values increased significantly in both groups (
P < .0001 for both). The differences for these values between groups I and II was statistically insignificant (
P > .05).
Collagen and silicone plugs both resulted in significant increases in aqueous tear volume, half-life of nuclear material on the ocular surface, and percentage of nuclear material retention. The groups’ post-insertion values for all parameters were similar. These results suggest that these two plug types have similar efficacy as treatments for dry eye in the short term. Further studies evaluating long-term results are required.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2005.02.031</identifier><identifier>PMID: 15939391</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Absorbable Implants ; Aged ; Biological and medical sciences ; Collagen ; Contact lenses ; Dry Eye Syndromes - diagnostic imaging ; Dry Eye Syndromes - metabolism ; Dry Eye Syndromes - surgery ; Female ; Humans ; Lacrimal Apparatus - diagnostic imaging ; Lacrimal Apparatus - secretion ; Male ; Medical sciences ; Medical treatment ; Middle Aged ; Miscellaneous ; Nuclear medicine ; Ophthalmology ; Prospective Studies ; Prostheses and Implants ; Prosthesis Implantation ; Radionuclide Imaging ; Retention ; Rose Bengal ; Silicone Elastomers ; Sodium Pertechnetate Tc 99m ; Studies ; Tears - secretion</subject><ispartof>American journal of ophthalmology, 2005-07, Vol.140 (1), p.88.e1-88.e7</ispartof><rights>2005 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jul 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-d057b8703ffef6b8030ef11196ff02f8fe6b6f7b841e41583ac76b8ee71eaf73</citedby><cites>FETCH-LOGICAL-c409t-d057b8703ffef6b8030ef11196ff02f8fe6b6f7b841e41583ac76b8ee71eaf73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajo.2005.02.031$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17012308$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15939391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Altan-Yaycioglu, Rana</creatorcontrib><creatorcontrib>Gencoglu, E. Arzu</creatorcontrib><creatorcontrib>Akova, Yonca Aydin</creatorcontrib><creatorcontrib>Dursun, Dilek</creatorcontrib><creatorcontrib>Cengiz, Fethi</creatorcontrib><creatorcontrib>Akman, Ahmet</creatorcontrib><title>Silicone Versus Collagen Plugs for Treating Dry Eye: Results of a Prospective Randomized Trial Including Lacrimal Scintigraphy</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>To compare the short-term efficacy of collagen and silicone plugs for treating dry eye using quantitative lacrimal scintigraphy.
Prospective randomized clinical trial.
In this institutional study, 24 dry eye patients were evaluated in two groups: group I (n = 22 eyes) received collagen plugs and group II (n = 26 eyes) received silicone plugs. Comparisons were made with normal control subjects (n = 22 eyes). Data for the Schirmer I test, tear break-up time, and ocular surface staining with rose bengal dye were recorded before and after punctal occlusion. Lacrimal scintigraphy was performed at each time point, and the time to half maximum activity on the ocular surface (T
1/2), and the percentage retention of activity on the ocular surface at the end of the dynamic study (RI) were recorded.
In both patient groups, Schirmer I results, tear break-up times, and rose bengal staining scores improved significantly after plug insertion. Mean T
1/2 values and RI values increased significantly in both groups (
P < .0001 for both). The differences for these values between groups I and II was statistically insignificant (
P > .05).
Collagen and silicone plugs both resulted in significant increases in aqueous tear volume, half-life of nuclear material on the ocular surface, and percentage of nuclear material retention. The groups’ post-insertion values for all parameters were similar. These results suggest that these two plug types have similar efficacy as treatments for dry eye in the short term. Further studies evaluating long-term results are required.</description><subject>Absorbable Implants</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Collagen</subject><subject>Contact lenses</subject><subject>Dry Eye Syndromes - diagnostic imaging</subject><subject>Dry Eye Syndromes - metabolism</subject><subject>Dry Eye Syndromes - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Lacrimal Apparatus - diagnostic imaging</subject><subject>Lacrimal Apparatus - secretion</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Nuclear medicine</subject><subject>Ophthalmology</subject><subject>Prospective Studies</subject><subject>Prostheses and Implants</subject><subject>Prosthesis Implantation</subject><subject>Radionuclide Imaging</subject><subject>Retention</subject><subject>Rose Bengal</subject><subject>Silicone Elastomers</subject><subject>Sodium Pertechnetate Tc 99m</subject><subject>Studies</subject><subject>Tears - secretion</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVGLEzEQx4MoXj39AL5IQPRt15nd7W6iT1JPPSh43BVfQ5qd1JRt0kt2D-qDn92UFg588Clk-P2Hmfkx9hqhRMD2w7bU21BWAPMSqhJqfMJmKDpZoJD4lM0AoCpkLZsL9iKlbf62XdM9Zxc4z9Va4oz9uXODM8ET_0kxTYkvwjDoDXl-M0ybxG2IfBVJj85v-Jd44FcH-shvKU3DmHiwXPObGNKezOgeiN9q34ed-019Tjk98Gtvhqk_hpfaRLfLpTvj_Og2Ue9_HV6yZ1YPiV6d30u2-nq1Wnwvlj--XS8-LwvTgByLHubdWnRQW0u2XQuogSwiytZaqKyw1K5bm5EGqcG5qLXpMkbUIWnb1Zfs_antPob7idKodi4Zypt6ClNSrYC2kUJm8O0_4DZM0efRFLZNI6RsoM4UniiTV0-RrNofV4sHhaCOZtRWZTPqaEZBpbKZnHlz7jytd9Q_Js4qMvDuDOhk9GCj9salR64DrGoQmft04ijf68FRVMk48oZ6F7MF1Qf3nzH-AtZzrFk</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Altan-Yaycioglu, Rana</creator><creator>Gencoglu, E. Arzu</creator><creator>Akova, Yonca Aydin</creator><creator>Dursun, Dilek</creator><creator>Cengiz, Fethi</creator><creator>Akman, Ahmet</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Silicone Versus Collagen Plugs for Treating Dry Eye: Results of a Prospective Randomized Trial Including Lacrimal Scintigraphy</title><author>Altan-Yaycioglu, Rana ; Gencoglu, E. Arzu ; Akova, Yonca Aydin ; Dursun, Dilek ; Cengiz, Fethi ; Akman, Ahmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-d057b8703ffef6b8030ef11196ff02f8fe6b6f7b841e41583ac76b8ee71eaf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Absorbable Implants</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Collagen</topic><topic>Contact lenses</topic><topic>Dry Eye Syndromes - diagnostic imaging</topic><topic>Dry Eye Syndromes - metabolism</topic><topic>Dry Eye Syndromes - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Lacrimal Apparatus - diagnostic imaging</topic><topic>Lacrimal Apparatus - secretion</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Nuclear medicine</topic><topic>Ophthalmology</topic><topic>Prospective Studies</topic><topic>Prostheses and Implants</topic><topic>Prosthesis Implantation</topic><topic>Radionuclide Imaging</topic><topic>Retention</topic><topic>Rose Bengal</topic><topic>Silicone Elastomers</topic><topic>Sodium Pertechnetate Tc 99m</topic><topic>Studies</topic><topic>Tears - secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Altan-Yaycioglu, Rana</creatorcontrib><creatorcontrib>Gencoglu, E. Arzu</creatorcontrib><creatorcontrib>Akova, Yonca Aydin</creatorcontrib><creatorcontrib>Dursun, Dilek</creatorcontrib><creatorcontrib>Cengiz, Fethi</creatorcontrib><creatorcontrib>Akman, Ahmet</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Altan-Yaycioglu, Rana</au><au>Gencoglu, E. Arzu</au><au>Akova, Yonca Aydin</au><au>Dursun, Dilek</au><au>Cengiz, Fethi</au><au>Akman, Ahmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Silicone Versus Collagen Plugs for Treating Dry Eye: Results of a Prospective Randomized Trial Including Lacrimal Scintigraphy</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>140</volume><issue>1</issue><spage>88.e1</spage><epage>88.e7</epage><pages>88.e1-88.e7</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>To compare the short-term efficacy of collagen and silicone plugs for treating dry eye using quantitative lacrimal scintigraphy.
Prospective randomized clinical trial.
In this institutional study, 24 dry eye patients were evaluated in two groups: group I (n = 22 eyes) received collagen plugs and group II (n = 26 eyes) received silicone plugs. Comparisons were made with normal control subjects (n = 22 eyes). Data for the Schirmer I test, tear break-up time, and ocular surface staining with rose bengal dye were recorded before and after punctal occlusion. Lacrimal scintigraphy was performed at each time point, and the time to half maximum activity on the ocular surface (T
1/2), and the percentage retention of activity on the ocular surface at the end of the dynamic study (RI) were recorded.
In both patient groups, Schirmer I results, tear break-up times, and rose bengal staining scores improved significantly after plug insertion. Mean T
1/2 values and RI values increased significantly in both groups (
P < .0001 for both). The differences for these values between groups I and II was statistically insignificant (
P > .05).
Collagen and silicone plugs both resulted in significant increases in aqueous tear volume, half-life of nuclear material on the ocular surface, and percentage of nuclear material retention. The groups’ post-insertion values for all parameters were similar. These results suggest that these two plug types have similar efficacy as treatments for dry eye in the short term. Further studies evaluating long-term results are required.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15939391</pmid><doi>10.1016/j.ajo.2005.02.031</doi><tpages>6</tpages></addata></record> |
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| ispartof | American journal of ophthalmology, 2005-07, Vol.140 (1), p.88.e1-88.e7 |
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| language | eng |
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| subjects | Absorbable Implants Aged Biological and medical sciences Collagen Contact lenses Dry Eye Syndromes - diagnostic imaging Dry Eye Syndromes - metabolism Dry Eye Syndromes - surgery Female Humans Lacrimal Apparatus - diagnostic imaging Lacrimal Apparatus - secretion Male Medical sciences Medical treatment Middle Aged Miscellaneous Nuclear medicine Ophthalmology Prospective Studies Prostheses and Implants Prosthesis Implantation Radionuclide Imaging Retention Rose Bengal Silicone Elastomers Sodium Pertechnetate Tc 99m Studies Tears - secretion |
| title | Silicone Versus Collagen Plugs for Treating Dry Eye: Results of a Prospective Randomized Trial Including Lacrimal Scintigraphy |
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