Pharmacokinetics, pharmacodynamics, and safety assessment of palifermin (rHuKGF) in healthy volunteers

Background Palifermin is a recombinant human keratinocyte growth factor approved to decrease the incidence and duration of severe oral mucositis in patients with hematologic malignancies who received myelotoxic therapy requiring hematopoietic stem cell support. Methods This randomized, double‐blind,...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2006-06, Vol.79 (6), p.558-569
Hauptverfasser:	Zia‐Amirhosseini, Parnian, Salfi, Margaret, Leese, Philip, Yates, Wayne, Danilenko, Dimitry M., Ring, Brian, Cesano, Alessandra, Sullivan, John T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biological and medical sciences Cell Proliferation - drug effects Dose-Response Relationship, Drug Double-Blind Method Epithelial Cells - drug effects Female Fibroblast Growth Factor 7 - administration & dosage Fibroblast Growth Factor 7 - blood Fibroblast Growth Factor 7 - pharmacokinetics Fibroblast Growth Factor 7 - pharmacology Humans Injections, Intravenous Male Medical sciences Mouth Mucosa - cytology Pharmacology. Drug treatments Stomatitis - drug therapy
Online-Zugang:	Volltext
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