Eosinophil and IgA responses in sheep infected with Teladorsagia circumcincta
Infections of sheep with the gastrointestinal nematode Teladorsagia circumcincta are characterised by increased concentrations of IgA, eosinophilia and mastocytosis but the interactions between these immune responses are unclear. We investigated the kinetics of the parasite-specific IgA and eosinoph...
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| Veröffentlicht in: | Veterinary immunology and immunopathology 2006-07, Vol.112 (1), p.62-66 |
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| container_title | Veterinary immunology and immunopathology |
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| creator | Henderson, N.G. Stear, M.J. |
| description | Infections of sheep with the gastrointestinal nematode
Teladorsagia circumcincta are characterised by increased concentrations of IgA, eosinophilia and mastocytosis but the interactions between these immune responses are unclear. We investigated the kinetics of the parasite-specific IgA and eosinophil responses in controlled infections in lambs to determine if there were any associations with subsequent worm growth and survival. IgA and eosinophil responses had very similar kinetics and variation in both responses accounted for more of the variation in adult worm length than either trait alone suggesting that IgA and eosinophils interact in regulating the growth of
T. circumcincta. Curiously, those animals with higher peak eosinophil responses had longer worms at slaughter emphasising the intriguing complexity of the immune responses to these parasitic infections. |
| doi_str_mv | 10.1016/j.vetimm.2006.03.012 |
| format | Article |
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Teladorsagia circumcincta are characterised by increased concentrations of IgA, eosinophilia and mastocytosis but the interactions between these immune responses are unclear. We investigated the kinetics of the parasite-specific IgA and eosinophil responses in controlled infections in lambs to determine if there were any associations with subsequent worm growth and survival. IgA and eosinophil responses had very similar kinetics and variation in both responses accounted for more of the variation in adult worm length than either trait alone suggesting that IgA and eosinophils interact in regulating the growth of
T. circumcincta. Curiously, those animals with higher peak eosinophil responses had longer worms at slaughter emphasising the intriguing complexity of the immune responses to these parasitic infections.</description><identifier>ISSN: 0165-2427</identifier><identifier>EISSN: 1873-2534</identifier><identifier>DOI: 10.1016/j.vetimm.2006.03.012</identifier><identifier>PMID: 16684572</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>animal growth ; Animals ; Antibodies, Helminth - biosynthesis ; Antibodies, Helminth - blood ; antibody formation ; cats ; Eosinophilia ; Eosinophilia - immunology ; Eosinophilia - parasitology ; Eosinophilia - veterinary ; eosinophils ; Eosinophils - immunology ; feline acquired immunodeficiency syndrome ; Female ; HIV infections ; IgA ; immune response ; Immunity, Mucosal ; immunoglobulin A ; Immunoglobulin A - biosynthesis ; Immunoglobulin A - blood ; immunology ; immunopathology ; Kinetics ; Lentivirus ; literature reviews ; nematode infections ; Sheep ; sheep diseases ; Sheep Diseases - immunology ; Sheep Diseases - parasitology ; Teladorsagia circumcincta ; Trichostrongyloidea - immunology ; Trichostrongyloidea - isolation & purification ; Trichostrongyloidiasis - immunology ; Trichostrongyloidiasis - parasitology ; Trichostrongyloidiasis - veterinary ; vaccine development ; veterinary parasitology</subject><ispartof>Veterinary immunology and immunopathology, 2006-07, Vol.112 (1), p.62-66</ispartof><rights>2006 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-37da048ae3b595f1a57e3e623a7d5441d71361a199527652f159b1f2f1787a883</citedby><cites>FETCH-LOGICAL-c384t-37da048ae3b595f1a57e3e623a7d5441d71361a199527652f159b1f2f1787a883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.vetimm.2006.03.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16684572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henderson, N.G.</creatorcontrib><creatorcontrib>Stear, M.J.</creatorcontrib><title>Eosinophil and IgA responses in sheep infected with Teladorsagia circumcincta</title><title>Veterinary immunology and immunopathology</title><addtitle>Vet Immunol Immunopathol</addtitle><description>Infections of sheep with the gastrointestinal nematode
Teladorsagia circumcincta are characterised by increased concentrations of IgA, eosinophilia and mastocytosis but the interactions between these immune responses are unclear. We investigated the kinetics of the parasite-specific IgA and eosinophil responses in controlled infections in lambs to determine if there were any associations with subsequent worm growth and survival. IgA and eosinophil responses had very similar kinetics and variation in both responses accounted for more of the variation in adult worm length than either trait alone suggesting that IgA and eosinophils interact in regulating the growth of
T. circumcincta. Curiously, those animals with higher peak eosinophil responses had longer worms at slaughter emphasising the intriguing complexity of the immune responses to these parasitic infections.</description><subject>animal growth</subject><subject>Animals</subject><subject>Antibodies, Helminth - biosynthesis</subject><subject>Antibodies, Helminth - blood</subject><subject>antibody formation</subject><subject>cats</subject><subject>Eosinophilia</subject><subject>Eosinophilia - immunology</subject><subject>Eosinophilia - parasitology</subject><subject>Eosinophilia - veterinary</subject><subject>eosinophils</subject><subject>Eosinophils - immunology</subject><subject>feline acquired immunodeficiency syndrome</subject><subject>Female</subject><subject>HIV infections</subject><subject>IgA</subject><subject>immune response</subject><subject>Immunity, Mucosal</subject><subject>immunoglobulin A</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Immunoglobulin A - blood</subject><subject>immunology</subject><subject>immunopathology</subject><subject>Kinetics</subject><subject>Lentivirus</subject><subject>literature reviews</subject><subject>nematode infections</subject><subject>Sheep</subject><subject>sheep diseases</subject><subject>Sheep Diseases - immunology</subject><subject>Sheep Diseases - parasitology</subject><subject>Teladorsagia circumcincta</subject><subject>Trichostrongyloidea - immunology</subject><subject>Trichostrongyloidea - isolation & purification</subject><subject>Trichostrongyloidiasis - immunology</subject><subject>Trichostrongyloidiasis - parasitology</subject><subject>Trichostrongyloidiasis - veterinary</subject><subject>vaccine development</subject><subject>veterinary parasitology</subject><issn>0165-2427</issn><issn>1873-2534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAURS0EokPhHyDIil2Cn7-zQaqqQisVsaBdWx7nZcajJA52pqj_Ho8yEruu7luce_V0CPkItAEK6uuhecIljGPDKFUN5Q0F9opswGheM8nFa7IpmKyZYPqCvMv5QCmVrTFvyQUoZYTUbEN-3sQcpjjvw1C5qavudldVwjzHKWOuwlTlPeJcjh79gl31Nyz76gEH18WU3S64yofkj6MPk1_ce_Kmd0PGD-e8JI_fbx6ub-v7Xz_urq_ua8-NWGquO0eFcci3spU9OKmRo2Lc6U4KAZ0GrsBB20qmlWQ9yHYLfUlttDOGX5Iv6-6c4p8j5sWOIXscBjdhPGarDFW8lSdQrKBPMeeEvZ1TGF16tkDtSaM92FWjPWm0lNuisdQ-nfeP2xG7_6WztwJ8XoHeRet2KWT7-JtR4BQADGhRiG8rgcXDU8Bksw84eexCKiptF8PLP_wDlE-N8w</recordid><startdate>20060715</startdate><enddate>20060715</enddate><creator>Henderson, N.G.</creator><creator>Stear, M.J.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060715</creationdate><title>Eosinophil and IgA responses in sheep infected with Teladorsagia circumcincta</title><author>Henderson, N.G. ; Stear, M.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-37da048ae3b595f1a57e3e623a7d5441d71361a199527652f159b1f2f1787a883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>animal growth</topic><topic>Animals</topic><topic>Antibodies, Helminth - biosynthesis</topic><topic>Antibodies, Helminth - blood</topic><topic>antibody formation</topic><topic>cats</topic><topic>Eosinophilia</topic><topic>Eosinophilia - immunology</topic><topic>Eosinophilia - parasitology</topic><topic>Eosinophilia - veterinary</topic><topic>eosinophils</topic><topic>Eosinophils - immunology</topic><topic>feline acquired immunodeficiency syndrome</topic><topic>Female</topic><topic>HIV infections</topic><topic>IgA</topic><topic>immune response</topic><topic>Immunity, Mucosal</topic><topic>immunoglobulin A</topic><topic>Immunoglobulin A - biosynthesis</topic><topic>Immunoglobulin A - blood</topic><topic>immunology</topic><topic>immunopathology</topic><topic>Kinetics</topic><topic>Lentivirus</topic><topic>literature reviews</topic><topic>nematode infections</topic><topic>Sheep</topic><topic>sheep diseases</topic><topic>Sheep Diseases - immunology</topic><topic>Sheep Diseases - parasitology</topic><topic>Teladorsagia circumcincta</topic><topic>Trichostrongyloidea - immunology</topic><topic>Trichostrongyloidea - isolation & purification</topic><topic>Trichostrongyloidiasis - immunology</topic><topic>Trichostrongyloidiasis - parasitology</topic><topic>Trichostrongyloidiasis - veterinary</topic><topic>vaccine development</topic><topic>veterinary parasitology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henderson, N.G.</creatorcontrib><creatorcontrib>Stear, M.J.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henderson, N.G.</au><au>Stear, M.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eosinophil and IgA responses in sheep infected with Teladorsagia circumcincta</atitle><jtitle>Veterinary immunology and immunopathology</jtitle><addtitle>Vet Immunol Immunopathol</addtitle><date>2006-07-15</date><risdate>2006</risdate><volume>112</volume><issue>1</issue><spage>62</spage><epage>66</epage><pages>62-66</pages><issn>0165-2427</issn><eissn>1873-2534</eissn><abstract>Infections of sheep with the gastrointestinal nematode
Teladorsagia circumcincta are characterised by increased concentrations of IgA, eosinophilia and mastocytosis but the interactions between these immune responses are unclear. We investigated the kinetics of the parasite-specific IgA and eosinophil responses in controlled infections in lambs to determine if there were any associations with subsequent worm growth and survival. IgA and eosinophil responses had very similar kinetics and variation in both responses accounted for more of the variation in adult worm length than either trait alone suggesting that IgA and eosinophils interact in regulating the growth of
T. circumcincta. Curiously, those animals with higher peak eosinophil responses had longer worms at slaughter emphasising the intriguing complexity of the immune responses to these parasitic infections.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>16684572</pmid><doi>10.1016/j.vetimm.2006.03.012</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | animal growth Animals Antibodies, Helminth - biosynthesis Antibodies, Helminth - blood antibody formation cats Eosinophilia Eosinophilia - immunology Eosinophilia - parasitology Eosinophilia - veterinary eosinophils Eosinophils - immunology feline acquired immunodeficiency syndrome Female HIV infections IgA immune response Immunity, Mucosal immunoglobulin A Immunoglobulin A - biosynthesis Immunoglobulin A - blood immunology immunopathology Kinetics Lentivirus literature reviews nematode infections Sheep sheep diseases Sheep Diseases - immunology Sheep Diseases - parasitology Teladorsagia circumcincta Trichostrongyloidea - immunology Trichostrongyloidea - isolation & purification Trichostrongyloidiasis - immunology Trichostrongyloidiasis - parasitology Trichostrongyloidiasis - veterinary vaccine development veterinary parasitology |
| title | Eosinophil and IgA responses in sheep infected with Teladorsagia circumcincta |
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