The clinical and genetic associations of anti-cyclic citrullinated peptide antibodies in psoriatic arthritis
Objectives. Antibodies recognizing a cyclic citrullinated peptide (anti-CCP) are highly specific for rheumatoid arthritis (RA) but their role in psoriatic arthritis (PsA) remains unclear. The aim of this study was therefore to investigate the prevalence of anti-CCP antibodies in PsA and assess their...
Gespeichert in:
| Veröffentlicht in: | Rheumatology (Oxford, England) England), 2005-08, Vol.44 (8), p.1056-1060 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1060 |
|---|---|
| container_issue | 8 |
| container_start_page | 1056 |
| container_title | Rheumatology (Oxford, England) |
| container_volume | 44 |
| creator | Korendowych, E. Owen, P. Ravindran, J. Carmichael, C. McHugh, N. |
| description | Objectives. Antibodies recognizing a cyclic citrullinated peptide (anti-CCP) are highly specific for rheumatoid arthritis (RA) but their role in psoriatic arthritis (PsA) remains unclear. The aim of this study was therefore to investigate the prevalence of anti-CCP antibodies in PsA and assess their clinical and genetic associations. Methods. One hundred and twenty-six patients with PsA, 40 patients with seropositive RA and 40 controls were tested for the presence of anti-CCP antibodies, rheumatoid factor (RF) and the HLA-DRB1 shared epitope. Clinical and radiological data were collected prospectively on all patients and compared between anti-CCP-positive and -negative patients. Results. Seven (5.6%) patients with PsA were positive for anti-CCP antibodies compared with 0% of controls and 97% of patients with seropositive RA. The presence of anti-CCP antibodies in PsA was significantly associated with the HLA-DRB1 shared epitope (P |
| doi_str_mv | 10.1093/rheumatology/keh686 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68063742</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>876390011</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-cff27edb1140e5d42fab4f410b770d5a805dcdebbea94d47a90fa4f5f39ffb4d3</originalsourceid><addsrcrecordid>eNqF0V1rFDEUBuAgiq3VXyDIIOjd2HxNMrmUrbXaBW8qiDchk5x0085OpkkG3H9v6i6teONVDpznPRBehF4T_IFgxU7TBpatKXGM17vTW9iIXjxBx4QL2mLG6NOHmfIj9CLnG4xxR1j_HB2RTmGiMD1G49UGGjuGKVgzNmZyzTVMUIJtTM7RBlNCnHITfd2V0NpdtbaxoaRlrClTwDUzzCU4-COG6ALkJkzNnGO6j9dLqWxSKCG_RM-8GTO8Orwn6Pv5p6vVRbv-9vnL6uO6tR3HpbXeUwluIIRj6Byn3gzcc4IHKbHrTI87Zx0MAxjFHZdGYW-47zxT3g_csRP0fn93TvFugVz0NmQL42gmiEvWoseCSU7_CymhVEkpKnz7D7yJS5rqJzRRnZA9Zbwitkc2xZwTeD2nsDVppwnW95XpvyvT-8pq6s3h9DJswT1mDh1V8O4ATK4l-WQmG_KjE0qJ2nd17d6FXODXw96kWy0kk52--PFTry9X-Oz88qs-Y78B8Gi2FQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>195678234</pqid></control><display><type>article</type><title>The clinical and genetic associations of anti-cyclic citrullinated peptide antibodies in psoriatic arthritis</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Korendowych, E. ; Owen, P. ; Ravindran, J. ; Carmichael, C. ; McHugh, N.</creator><creatorcontrib>Korendowych, E. ; Owen, P. ; Ravindran, J. ; Carmichael, C. ; McHugh, N.</creatorcontrib><description>Objectives. Antibodies recognizing a cyclic citrullinated peptide (anti-CCP) are highly specific for rheumatoid arthritis (RA) but their role in psoriatic arthritis (PsA) remains unclear. The aim of this study was therefore to investigate the prevalence of anti-CCP antibodies in PsA and assess their clinical and genetic associations. Methods. One hundred and twenty-six patients with PsA, 40 patients with seropositive RA and 40 controls were tested for the presence of anti-CCP antibodies, rheumatoid factor (RF) and the HLA-DRB1 shared epitope. Clinical and radiological data were collected prospectively on all patients and compared between anti-CCP-positive and -negative patients. Results. Seven (5.6%) patients with PsA were positive for anti-CCP antibodies compared with 0% of controls and 97% of patients with seropositive RA. The presence of anti-CCP antibodies in PsA was significantly associated with the HLA-DRB1 shared epitope (P<0.005), erosive disease (P<0.05), number of swollen joints (P<0.02) and DMARD use (P<0.05). Conclusions. Overall, the increased prevalence of anti-CCP antibodies in this PsA population failed to reach statistical significance. However, when present, they were a marker of disease severity and had RA-linked MHC class II associations. Further studies are needed in a larger population of patients with PsA and appropriate controls to confirm any true association that may be present.</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/keh686</identifier><identifier>PMID: 15901902</identifier><identifier>CODEN: BJRHDF</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anti-citrullinated peptide antibodies ; Arthritis, Psoriatic - genetics ; Arthritis, Psoriatic - immunology ; Arthritis, Rheumatoid - immunology ; Autoantibodies - blood ; Biological and medical sciences ; Biomarkers - blood ; Dermatology ; Diseases of the osteoarticular system ; Female ; HLA-DR Antigens - blood ; HLA-DRB1 Chains ; Humans ; Inflammatory joint diseases ; Male ; Medical sciences ; Middle Aged ; Peptides, Cyclic - immunology ; Prospective Studies ; Psoriasis. Parapsoriasis. Lichen ; Psoriatic arthritis ; Rheumatoid Factor - blood ; Severity of Illness Index ; Shared epitope</subject><ispartof>Rheumatology (Oxford, England), 2005-08, Vol.44 (8), p.1056-1060</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Aug 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-cff27edb1140e5d42fab4f410b770d5a805dcdebbea94d47a90fa4f5f39ffb4d3</citedby><cites>FETCH-LOGICAL-c540t-cff27edb1140e5d42fab4f410b770d5a805dcdebbea94d47a90fa4f5f39ffb4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16996332$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15901902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Korendowych, E.</creatorcontrib><creatorcontrib>Owen, P.</creatorcontrib><creatorcontrib>Ravindran, J.</creatorcontrib><creatorcontrib>Carmichael, C.</creatorcontrib><creatorcontrib>McHugh, N.</creatorcontrib><title>The clinical and genetic associations of anti-cyclic citrullinated peptide antibodies in psoriatic arthritis</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology</addtitle><description>Objectives. Antibodies recognizing a cyclic citrullinated peptide (anti-CCP) are highly specific for rheumatoid arthritis (RA) but their role in psoriatic arthritis (PsA) remains unclear. The aim of this study was therefore to investigate the prevalence of anti-CCP antibodies in PsA and assess their clinical and genetic associations. Methods. One hundred and twenty-six patients with PsA, 40 patients with seropositive RA and 40 controls were tested for the presence of anti-CCP antibodies, rheumatoid factor (RF) and the HLA-DRB1 shared epitope. Clinical and radiological data were collected prospectively on all patients and compared between anti-CCP-positive and -negative patients. Results. Seven (5.6%) patients with PsA were positive for anti-CCP antibodies compared with 0% of controls and 97% of patients with seropositive RA. The presence of anti-CCP antibodies in PsA was significantly associated with the HLA-DRB1 shared epitope (P<0.005), erosive disease (P<0.05), number of swollen joints (P<0.02) and DMARD use (P<0.05). Conclusions. Overall, the increased prevalence of anti-CCP antibodies in this PsA population failed to reach statistical significance. However, when present, they were a marker of disease severity and had RA-linked MHC class II associations. Further studies are needed in a larger population of patients with PsA and appropriate controls to confirm any true association that may be present.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-citrullinated peptide antibodies</subject><subject>Arthritis, Psoriatic - genetics</subject><subject>Arthritis, Psoriatic - immunology</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Dermatology</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>HLA-DR Antigens - blood</subject><subject>HLA-DRB1 Chains</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Peptides, Cyclic - immunology</subject><subject>Prospective Studies</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Psoriatic arthritis</subject><subject>Rheumatoid Factor - blood</subject><subject>Severity of Illness Index</subject><subject>Shared epitope</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V1rFDEUBuAgiq3VXyDIIOjd2HxNMrmUrbXaBW8qiDchk5x0085OpkkG3H9v6i6teONVDpznPRBehF4T_IFgxU7TBpatKXGM17vTW9iIXjxBx4QL2mLG6NOHmfIj9CLnG4xxR1j_HB2RTmGiMD1G49UGGjuGKVgzNmZyzTVMUIJtTM7RBlNCnHITfd2V0NpdtbaxoaRlrClTwDUzzCU4-COG6ALkJkzNnGO6j9dLqWxSKCG_RM-8GTO8Orwn6Pv5p6vVRbv-9vnL6uO6tR3HpbXeUwluIIRj6Byn3gzcc4IHKbHrTI87Zx0MAxjFHZdGYW-47zxT3g_csRP0fn93TvFugVz0NmQL42gmiEvWoseCSU7_CymhVEkpKnz7D7yJS5rqJzRRnZA9Zbwitkc2xZwTeD2nsDVppwnW95XpvyvT-8pq6s3h9DJswT1mDh1V8O4ATK4l-WQmG_KjE0qJ2nd17d6FXODXw96kWy0kk52--PFTry9X-Oz88qs-Y78B8Gi2FQ</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Korendowych, E.</creator><creator>Owen, P.</creator><creator>Ravindran, J.</creator><creator>Carmichael, C.</creator><creator>McHugh, N.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>The clinical and genetic associations of anti-cyclic citrullinated peptide antibodies in psoriatic arthritis</title><author>Korendowych, E. ; Owen, P. ; Ravindran, J. ; Carmichael, C. ; McHugh, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-cff27edb1140e5d42fab4f410b770d5a805dcdebbea94d47a90fa4f5f39ffb4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-citrullinated peptide antibodies</topic><topic>Arthritis, Psoriatic - genetics</topic><topic>Arthritis, Psoriatic - immunology</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Dermatology</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>HLA-DR Antigens - blood</topic><topic>HLA-DRB1 Chains</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Peptides, Cyclic - immunology</topic><topic>Prospective Studies</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Psoriatic arthritis</topic><topic>Rheumatoid Factor - blood</topic><topic>Severity of Illness Index</topic><topic>Shared epitope</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Korendowych, E.</creatorcontrib><creatorcontrib>Owen, P.</creatorcontrib><creatorcontrib>Ravindran, J.</creatorcontrib><creatorcontrib>Carmichael, C.</creatorcontrib><creatorcontrib>McHugh, N.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Korendowych, E.</au><au>Owen, P.</au><au>Ravindran, J.</au><au>Carmichael, C.</au><au>McHugh, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical and genetic associations of anti-cyclic citrullinated peptide antibodies in psoriatic arthritis</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>44</volume><issue>8</issue><spage>1056</spage><epage>1060</epage><pages>1056-1060</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><coden>BJRHDF</coden><abstract>Objectives. Antibodies recognizing a cyclic citrullinated peptide (anti-CCP) are highly specific for rheumatoid arthritis (RA) but their role in psoriatic arthritis (PsA) remains unclear. The aim of this study was therefore to investigate the prevalence of anti-CCP antibodies in PsA and assess their clinical and genetic associations. Methods. One hundred and twenty-six patients with PsA, 40 patients with seropositive RA and 40 controls were tested for the presence of anti-CCP antibodies, rheumatoid factor (RF) and the HLA-DRB1 shared epitope. Clinical and radiological data were collected prospectively on all patients and compared between anti-CCP-positive and -negative patients. Results. Seven (5.6%) patients with PsA were positive for anti-CCP antibodies compared with 0% of controls and 97% of patients with seropositive RA. The presence of anti-CCP antibodies in PsA was significantly associated with the HLA-DRB1 shared epitope (P<0.005), erosive disease (P<0.05), number of swollen joints (P<0.02) and DMARD use (P<0.05). Conclusions. Overall, the increased prevalence of anti-CCP antibodies in this PsA population failed to reach statistical significance. However, when present, they were a marker of disease severity and had RA-linked MHC class II associations. Further studies are needed in a larger population of patients with PsA and appropriate controls to confirm any true association that may be present.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15901902</pmid><doi>10.1093/rheumatology/keh686</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1462-0324 |
| ispartof | Rheumatology (Oxford, England), 2005-08, Vol.44 (8), p.1056-1060 |
| issn | 1462-0324 1462-0332 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68063742 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Anti-citrullinated peptide antibodies Arthritis, Psoriatic - genetics Arthritis, Psoriatic - immunology Arthritis, Rheumatoid - immunology Autoantibodies - blood Biological and medical sciences Biomarkers - blood Dermatology Diseases of the osteoarticular system Female HLA-DR Antigens - blood HLA-DRB1 Chains Humans Inflammatory joint diseases Male Medical sciences Middle Aged Peptides, Cyclic - immunology Prospective Studies Psoriasis. Parapsoriasis. Lichen Psoriatic arthritis Rheumatoid Factor - blood Severity of Illness Index Shared epitope |
| title | The clinical and genetic associations of anti-cyclic citrullinated peptide antibodies in psoriatic arthritis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T11%3A27%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20clinical%20and%20genetic%20associations%20of%20anti-cyclic%20citrullinated%20peptide%20antibodies%20in%20psoriatic%20arthritis&rft.jtitle=Rheumatology%20(Oxford,%20England)&rft.au=Korendowych,%20E.&rft.date=2005-08-01&rft.volume=44&rft.issue=8&rft.spage=1056&rft.epage=1060&rft.pages=1056-1060&rft.issn=1462-0324&rft.eissn=1462-0332&rft.coden=BJRHDF&rft_id=info:doi/10.1093/rheumatology/keh686&rft_dat=%3Cproquest_cross%3E876390011%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=195678234&rft_id=info:pmid/15901902&rfr_iscdi=true |