Experimental infection of rhesus macaques with Streptococcus pneumoniae: a possible model for vaccine assessment
Background We explored the possibility of using normal adult rhesus macaques for the preclinical assessment of safety, immunogenicity, and efficacy of newly developed vaccines against Streptococcus pneumoniae infection of the lung. Methods Our primary objective was to determine whether an intra‐br...
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| Veröffentlicht in: | Journal of medical primatology 2006-06, Vol.35 (3), p.113-122 |
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| creator | Philipp, Mario T. Purcell, Jeanette E. Martin, Dale S. Buck, Wayne R. Plauché, Gail B. Ribka, Erin P. DeNoel, Philippe Hermand, Philippe Leiva, Lily E. Bagby, Gregory J. Nelson, Steve |
| description | Background We explored the possibility of using normal adult rhesus macaques for the preclinical assessment of safety, immunogenicity, and efficacy of newly developed vaccines against Streptococcus pneumoniae infection of the lung.
Methods Our primary objective was to determine whether an intra‐bronchial inoculum of at least 106S. pneumoniae colony‐forming units, or one as high as 108–109 organisms, could detectably survive in rhesus macaques for a period longer than 1–2 weeks. If so, we hypothesized, it would be possible to observe signs of pneumonia commonly observed in humans, and discriminate between vaccinated/protected animals and controls. Infection was detectable in bronchoalveolar lavage fluids 3–5 weeks post‐inoculation.
Results The clinical course of disease mimicked aspects of that of human pneumococcal pneumonia. Signs of inflammation typical of the disease in humans, such as elevated concentrations of neutrophils and of pro‐inflammatory cytokines in bronchoalveolar lavage fluids were also observed.
Conclusions These findings underscore the utility of this model to assess the safety, immunogenicity, and efficacy of newly developed S. pneumoniae vaccines. |
| doi_str_mv | 10.1111/j.1600-0684.2006.00164.x |
| format | Article |
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Methods Our primary objective was to determine whether an intra‐bronchial inoculum of at least 106S. pneumoniae colony‐forming units, or one as high as 108–109 organisms, could detectably survive in rhesus macaques for a period longer than 1–2 weeks. If so, we hypothesized, it would be possible to observe signs of pneumonia commonly observed in humans, and discriminate between vaccinated/protected animals and controls. Infection was detectable in bronchoalveolar lavage fluids 3–5 weeks post‐inoculation.
Results The clinical course of disease mimicked aspects of that of human pneumococcal pneumonia. Signs of inflammation typical of the disease in humans, such as elevated concentrations of neutrophils and of pro‐inflammatory cytokines in bronchoalveolar lavage fluids were also observed.
Conclusions These findings underscore the utility of this model to assess the safety, immunogenicity, and efficacy of newly developed S. pneumoniae vaccines.</description><identifier>ISSN: 0047-2565</identifier><identifier>EISSN: 1600-0684</identifier><identifier>DOI: 10.1111/j.1600-0684.2006.00164.x</identifier><identifier>PMID: 16764668</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Bronchoalveolar Lavage Fluid - immunology ; Bronchoalveolar Lavage Fluid - microbiology ; Colony Count, Microbial ; Disease Models, Animal ; Interleukin-1 - metabolism ; Interleukin-6 - metabolism ; Leukocyte Count ; Longitudinal Studies ; Macaca mulatta ; Male ; Monkey Diseases - immunology ; Monkey Diseases - microbiology ; Monkey Diseases - prevention & control ; Pneumococcal Vaccines - immunology ; Pneumococcal Vaccines - pharmacology ; Pneumonia, Pneumococcal - immunology ; Pneumonia, Pneumococcal - microbiology ; Pneumonia, Pneumococcal - prevention & control ; Pneumonia, Pneumococcal - veterinary ; rhesus ; Streptococcus pneumoniae ; Streptococcus pneumoniae - immunology ; Tumor Necrosis Factor-alpha - metabolism ; vaccine</subject><ispartof>Journal of medical primatology, 2006-06, Vol.35 (3), p.113-122</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4044-540aa93a4c898dc881e71090ed6c75c54826dd980a82e79ec3e754b276c0eb503</citedby><cites>FETCH-LOGICAL-c4044-540aa93a4c898dc881e71090ed6c75c54826dd980a82e79ec3e754b276c0eb503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0684.2006.00164.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0684.2006.00164.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16764668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Philipp, Mario T.</creatorcontrib><creatorcontrib>Purcell, Jeanette E.</creatorcontrib><creatorcontrib>Martin, Dale S.</creatorcontrib><creatorcontrib>Buck, Wayne R.</creatorcontrib><creatorcontrib>Plauché, Gail B.</creatorcontrib><creatorcontrib>Ribka, Erin P.</creatorcontrib><creatorcontrib>DeNoel, Philippe</creatorcontrib><creatorcontrib>Hermand, Philippe</creatorcontrib><creatorcontrib>Leiva, Lily E.</creatorcontrib><creatorcontrib>Bagby, Gregory J.</creatorcontrib><creatorcontrib>Nelson, Steve</creatorcontrib><title>Experimental infection of rhesus macaques with Streptococcus pneumoniae: a possible model for vaccine assessment</title><title>Journal of medical primatology</title><addtitle>J Med Primatol</addtitle><description>Background We explored the possibility of using normal adult rhesus macaques for the preclinical assessment of safety, immunogenicity, and efficacy of newly developed vaccines against Streptococcus pneumoniae infection of the lung.
Methods Our primary objective was to determine whether an intra‐bronchial inoculum of at least 106S. pneumoniae colony‐forming units, or one as high as 108–109 organisms, could detectably survive in rhesus macaques for a period longer than 1–2 weeks. If so, we hypothesized, it would be possible to observe signs of pneumonia commonly observed in humans, and discriminate between vaccinated/protected animals and controls. Infection was detectable in bronchoalveolar lavage fluids 3–5 weeks post‐inoculation.
Results The clinical course of disease mimicked aspects of that of human pneumococcal pneumonia. Signs of inflammation typical of the disease in humans, such as elevated concentrations of neutrophils and of pro‐inflammatory cytokines in bronchoalveolar lavage fluids were also observed.
Conclusions These findings underscore the utility of this model to assess the safety, immunogenicity, and efficacy of newly developed S. pneumoniae vaccines.</description><subject>Animals</subject><subject>Bronchoalveolar Lavage Fluid - immunology</subject><subject>Bronchoalveolar Lavage Fluid - microbiology</subject><subject>Colony Count, Microbial</subject><subject>Disease Models, Animal</subject><subject>Interleukin-1 - metabolism</subject><subject>Interleukin-6 - metabolism</subject><subject>Leukocyte Count</subject><subject>Longitudinal Studies</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Monkey Diseases - immunology</subject><subject>Monkey Diseases - microbiology</subject><subject>Monkey Diseases - prevention & control</subject><subject>Pneumococcal Vaccines - immunology</subject><subject>Pneumococcal Vaccines - pharmacology</subject><subject>Pneumonia, Pneumococcal - immunology</subject><subject>Pneumonia, Pneumococcal - microbiology</subject><subject>Pneumonia, Pneumococcal - prevention & control</subject><subject>Pneumonia, Pneumococcal - veterinary</subject><subject>rhesus</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>vaccine</subject><issn>0047-2565</issn><issn>1600-0684</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P3DAQhi1UBFvKX6h84pZ0kji2U3GpEF8V0Ja2ourF8joT4W0SBzuB5d_XYVf0Wl_G0rzPzOghhGaQZvF9WKUZB0iAS5bmADwFyDhL1ztk8dp4QxYATCR5yct98jaEFQAUrGJ7ZD_jgjPO5YIMp-sBve2wH3VLbd-gGa3rqWuov8cwBdppox8mDPTJjvf0--hxGJ1xxsTe0OPUud5q_Eg1HVwIdtki7VyNLW2cp4_aGNsj1SFgCPOWd2S30W3Aw209ID_PTn-cXCRXX84vTz5dJYYBY0nJQOuq0MzIStZGygxFBhVgzY0oTclkzuu6kqBljqJCU6Ao2TIX3AAuSygOyNFm7uDdfP6oOhsMtq3u0U1BcQm8ACliUG6Cxsf7PTZqiD60f1YZqNm2WqlZqpqlqtm2erGt1hF9v90xLTus_4FbvTFwvAk82Raf_3uw-nz9NX4inmxwG0Zcv-La_1FcFKJUdzfn6vev_PY2598UK_4C3GaevQ</recordid><startdate>200606</startdate><enddate>200606</enddate><creator>Philipp, Mario T.</creator><creator>Purcell, Jeanette E.</creator><creator>Martin, Dale S.</creator><creator>Buck, Wayne R.</creator><creator>Plauché, Gail B.</creator><creator>Ribka, Erin P.</creator><creator>DeNoel, Philippe</creator><creator>Hermand, Philippe</creator><creator>Leiva, Lily E.</creator><creator>Bagby, Gregory J.</creator><creator>Nelson, Steve</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200606</creationdate><title>Experimental infection of rhesus macaques with Streptococcus pneumoniae: a possible model for vaccine assessment</title><author>Philipp, Mario T. ; Purcell, Jeanette E. ; Martin, Dale S. ; Buck, Wayne R. ; Plauché, Gail B. ; Ribka, Erin P. ; DeNoel, Philippe ; Hermand, Philippe ; Leiva, Lily E. ; Bagby, Gregory J. ; Nelson, Steve</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4044-540aa93a4c898dc881e71090ed6c75c54826dd980a82e79ec3e754b276c0eb503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Bronchoalveolar Lavage Fluid - immunology</topic><topic>Bronchoalveolar Lavage Fluid - microbiology</topic><topic>Colony Count, Microbial</topic><topic>Disease Models, Animal</topic><topic>Interleukin-1 - metabolism</topic><topic>Interleukin-6 - metabolism</topic><topic>Leukocyte Count</topic><topic>Longitudinal Studies</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>Monkey Diseases - immunology</topic><topic>Monkey Diseases - microbiology</topic><topic>Monkey Diseases - prevention & control</topic><topic>Pneumococcal Vaccines - immunology</topic><topic>Pneumococcal Vaccines - pharmacology</topic><topic>Pneumonia, Pneumococcal - immunology</topic><topic>Pneumonia, Pneumococcal - microbiology</topic><topic>Pneumonia, Pneumococcal - prevention & control</topic><topic>Pneumonia, Pneumococcal - veterinary</topic><topic>rhesus</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>vaccine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Philipp, Mario T.</creatorcontrib><creatorcontrib>Purcell, Jeanette E.</creatorcontrib><creatorcontrib>Martin, Dale S.</creatorcontrib><creatorcontrib>Buck, Wayne R.</creatorcontrib><creatorcontrib>Plauché, Gail B.</creatorcontrib><creatorcontrib>Ribka, Erin P.</creatorcontrib><creatorcontrib>DeNoel, Philippe</creatorcontrib><creatorcontrib>Hermand, Philippe</creatorcontrib><creatorcontrib>Leiva, Lily E.</creatorcontrib><creatorcontrib>Bagby, Gregory J.</creatorcontrib><creatorcontrib>Nelson, Steve</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical primatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Philipp, Mario T.</au><au>Purcell, Jeanette E.</au><au>Martin, Dale S.</au><au>Buck, Wayne R.</au><au>Plauché, Gail B.</au><au>Ribka, Erin P.</au><au>DeNoel, Philippe</au><au>Hermand, Philippe</au><au>Leiva, Lily E.</au><au>Bagby, Gregory J.</au><au>Nelson, Steve</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental infection of rhesus macaques with Streptococcus pneumoniae: a possible model for vaccine assessment</atitle><jtitle>Journal of medical primatology</jtitle><addtitle>J Med Primatol</addtitle><date>2006-06</date><risdate>2006</risdate><volume>35</volume><issue>3</issue><spage>113</spage><epage>122</epage><pages>113-122</pages><issn>0047-2565</issn><eissn>1600-0684</eissn><abstract>Background We explored the possibility of using normal adult rhesus macaques for the preclinical assessment of safety, immunogenicity, and efficacy of newly developed vaccines against Streptococcus pneumoniae infection of the lung.
Methods Our primary objective was to determine whether an intra‐bronchial inoculum of at least 106S. pneumoniae colony‐forming units, or one as high as 108–109 organisms, could detectably survive in rhesus macaques for a period longer than 1–2 weeks. If so, we hypothesized, it would be possible to observe signs of pneumonia commonly observed in humans, and discriminate between vaccinated/protected animals and controls. Infection was detectable in bronchoalveolar lavage fluids 3–5 weeks post‐inoculation.
Results The clinical course of disease mimicked aspects of that of human pneumococcal pneumonia. Signs of inflammation typical of the disease in humans, such as elevated concentrations of neutrophils and of pro‐inflammatory cytokines in bronchoalveolar lavage fluids were also observed.
Conclusions These findings underscore the utility of this model to assess the safety, immunogenicity, and efficacy of newly developed S. pneumoniae vaccines.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16764668</pmid><doi>10.1111/j.1600-0684.2006.00164.x</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Bronchoalveolar Lavage Fluid - immunology Bronchoalveolar Lavage Fluid - microbiology Colony Count, Microbial Disease Models, Animal Interleukin-1 - metabolism Interleukin-6 - metabolism Leukocyte Count Longitudinal Studies Macaca mulatta Male Monkey Diseases - immunology Monkey Diseases - microbiology Monkey Diseases - prevention & control Pneumococcal Vaccines - immunology Pneumococcal Vaccines - pharmacology Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - microbiology Pneumonia, Pneumococcal - prevention & control Pneumonia, Pneumococcal - veterinary rhesus Streptococcus pneumoniae Streptococcus pneumoniae - immunology Tumor Necrosis Factor-alpha - metabolism vaccine |
| title | Experimental infection of rhesus macaques with Streptococcus pneumoniae: a possible model for vaccine assessment |
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