Protein-tyrosine phosphatase (PTP) wedge domain peptides: a novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function

Inhibition of protein-tyrosine phosphatases (PTPs) counterbalancing protein-tyrosine kinases (PTKs) offers a strategy for augmenting PTK actions. Conservation of PTP catalytic sites limits development of specific PTP inhibitors. A number of receptor PTPs, including the leukocyte common antigen-relat...

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Veröffentlicht in:	The Journal of biological chemistry 2006-06, Vol.281 (24), p.16482-16492
Hauptverfasser:	Xie, Youmei, Massa, Stephen M, Ensslen-Craig, Sonya E, Major, Denice L, Yang, Tao, Tisi, Michelle A, Derevyanny, Vicki D, Runge, William O, Mehta, Brijesh P, Moore, Laura A, Brady-Kalnay, Susann M, Longo, Frank M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Catalytic Domain Cell Proliferation Fluorescent Dyes - pharmacology Molecular Sequence Data Nerve Growth Factors - metabolism Neurons - metabolism PC12 Cells Protein Structure, Tertiary Protein Tyrosine Phosphatases - metabolism Protein Tyrosine Phosphatases - physiology Rats Receptor, trkA - metabolism
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