The design, synthesis and evaluation of high affinity macrocyclic carbohydrate inhibitors

Carbohydrate-protein interactions have been investigated for a model system of a monoclonal antibody, SYA/J6, which binds a trisaccharide epitope of the O-polysaccharide of the Shigella flexneri variant Y lipopolysaccharide. The thermodynamics of binding for the methyl glycoside of the native trisac...

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Veröffentlicht in:	Organic & biomolecular chemistry 2005-08, Vol.3 (15), p.2723-2732
Hauptverfasser:	McGavin, Robert S, Gagne, Rod A, Chervenak, Mary C, Bundle, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Calorimetry Carbohydrate Conformation Carbohydrate Sequence Carbohydrates - antagonists & inhibitors Enzyme-Linked Immunosorbent Assay Macrocyclic Compounds - chemical synthesis Macrocyclic Compounds - chemistry Macrocyclic Compounds - pharmacology Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Sequence Data Thermodynamics
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