Simultaneous Targeting of CD3 on T Cells and CD40 on B or Dendritic Cells Augments the Antitumor Reactivity of Tumor-Primed Lymph Node Cells

To date, molecular targets chosen for Ab activation to generate antitumor effector cells have been confined on T cells, such as TCR/CD3, CD28, CD137 (4-1BB), CD134 (OX40), and inducible costimulator. In this report we investigated the immune function of murine tumor-draining lymph node (TDLN) cells...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-08, Vol.175 (3), p.1424-1432
Hauptverfasser:	Li, Qiao, Grover, Amelia C, Donald, Elizabeth J, Carr, Abbey, Yu, Jiyun, Whitfield, Joel, Nelson, Mark, Takeshita, Nobuhiro, Chang, Alfred E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - therapeutic use Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism Antigens, CD19 - biosynthesis B-Lymphocytes - immunology B-Lymphocytes - metabolism CD11c Antigen - biosynthesis CD3 Complex - immunology CD3 Complex - metabolism CD40 Antigens - biosynthesis CD40 Antigens - immunology CD40 Antigens - metabolism CD40 Ligand - immunology CD40 Ligand - metabolism Cell Line, Tumor Dendritic Cells - immunology Dendritic Cells - metabolism Female Fibrosarcoma - immunology Fibrosarcoma - prevention & control Immunotherapy, Adoptive - methods Interferon-gamma - metabolism Interleukin-12 - biosynthesis Interleukin-4 - antagonists & inhibitors Interleukin-4 - metabolism Lymph Nodes - immunology Lymph Nodes - metabolism Lymph Nodes - pathology Lymph Nodes - transplantation Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Mice, Knockout Neoplasm Transplantation T-Lymphocytes - immunology T-Lymphocytes - metabolism
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