Multiple members of the TNF superfamily contribute to IFN-gamma-mediated inhibition of erythropoiesis

IFN-gamma inhibits the growth and differentiation of erythroid precursor cells and mediates hemopoietic suppression through mechanisms that are not completely understood. We found that treatment of human erythroid precursor cells with IFN-gamma up-regulates the expression of multiple members of the...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-08, Vol.175 (3), p.1464-1472
Hauptverfasser:	Felli, Nadia, Pedini, Francesca, Zeuner, Ann, Petrucci, Eleonora, Testa, Ugo, Conticello, Concetta, Biffoni, Mauro, Di Cataldo, Andrea, Winkles, Jeffrey A, Peschle, Cesare, De Maria, Ruggero
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Regulatory Proteins Carrier Proteins - biosynthesis Carrier Proteins - physiology Cell Differentiation - immunology Cell Proliferation Cells, Cultured Cytokine TWEAK Erythroblasts - cytology Erythroblasts - immunology Erythroblasts - metabolism Erythropoiesis - immunology Fas Ligand Protein Growth Inhibitors - physiology Humans Immunologic Factors - biosynthesis Immunologic Factors - physiology Interferon-gamma - physiology Ligands Membrane Glycoproteins - physiology Membrane Proteins - biosynthesis Membrane Proteins - physiology Receptors, Tumor Necrosis Factor - biosynthesis Receptors, Tumor Necrosis Factor - physiology TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha - physiology Tumor Necrosis Factors - biosynthesis Tumor Necrosis Factors - physiology TWEAK Receptor Up-Regulation - immunology
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