Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia

Mutations in the Nucleophosmin (NPM1) gene have been recently described to occur in about one-third of acute myeloid leukemias (AML) and represent the most frequent genetic alteration currently known in this subset. These mutations generate an elongated NPM1 protein that localizes aberrantly in the...

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Veröffentlicht in:	Leukemia 2005-08, Vol.19 (8), p.1479-1482
Hauptverfasser:	NOGUERA, N. I, AMMATUNA, E, ZANGRILLI, D, LAVORGNA, S, DIVONA, M, BUCCISANO, F, AMADORI, S, MECUCCI, C, FALINI, B, LO-COCO, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Acute myeloid leukemia Assaying Biological and medical sciences Capillary electrophoresis Cytoplasm Electrophoresis Electrophoresis, Capillary FLT3 gene fms-Like Tyrosine Kinase 3 Fusion protein Gene banks Genetic analysis Genetic screening Hematologic and hematopoietic diseases Hematology Humans Karyotypes Leukemia Leukemia, Myeloid - diagnosis Leukemia, Myeloid - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Localization Medical sciences Methods Mutation Nuclear Proteins - genetics Polymerase chain reaction Proteins Proto-Oncogene Proteins - genetics Receptor Protein-Tyrosine Kinases - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Neoplasm Sequence Analysis, RNA Tandem Repeat Sequences
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