Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites

Tail-anchored proteins contain a single transmembrane domain (TMD) followed by a short C-terminal domain extending into the organellar lumen. Tail-anchored proteins are thought to target to the correct subcellular compartment by virtue of general physicochemical properties of their C-termini; howeve...

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Veröffentlicht in:	Journal of cell science 2006-06, Vol.119 (12), p.2508-2517
Hauptverfasser:	Halbach, A, Landgraf, C, Lorenzen, S, Rosenkranz, K, Volkmer-Engert, R, Erdmann, R, Rottensteiner, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Humans Intracellular Membranes - metabolism Membrane Proteins - antagonists & inhibitors Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Peroxisomes - metabolism Phosphoproteins - chemistry Phosphoproteins - metabolism RNA, Small Interfering - pharmacology Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism
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