alpha-Tocopherol affects neuronal plasticity in adult rat dentate gyrus: the possible role of PKCdelta

Hippocampus dentate gyrus (DG) is characterized by neuronal plasticity processes in adulthood, and polysialylation of NCAM promotes neuronal plasticity. In previous investigations we found that alpha-tocopherol increased the PSA-NCAM-positive granule cell number in adult rat DG, suggesting that alph...

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Veröffentlicht in:	Journal of neurobiology 2006-07, Vol.66 (8), p.793-810
Hauptverfasser:	Ferri, Paola, Cecchini, Tiziana, Ambrogini, Patrizia, Betti, Michele, Cuppini, Riccardo, Del Grande, Paolo, Ciaroni, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Tocopherol - pharmacology Animals Antioxidants - pharmacology Dendrites - metabolism Dendrites - ultrastructure Dentate Gyrus - drug effects Dentate Gyrus - enzymology Dentate Gyrus - ultrastructure Enzyme Inhibitors - pharmacology Immunohistochemistry Male Microscopy, Electron, Transmission Neural Cell Adhesion Molecule L1 - drug effects Neural Cell Adhesion Molecule L1 - metabolism Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Presynaptic Terminals - drug effects Presynaptic Terminals - enzymology Presynaptic Terminals - ultrastructure Protein Kinase C-delta - antagonists & inhibitors Protein Kinase C-delta - metabolism Rats Rats, Sprague-Dawley Sialic Acids - metabolism Synaptic Membranes - drug effects Synaptic Membranes - enzymology Synaptic Membranes - ultrastructure Synaptophysin - drug effects Synaptophysin - metabolism Up-Regulation - drug effects Up-Regulation - physiology
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